Osler-Weber-Rendu syndrome is an inherited disorder of the blood vessels that can cause excessive bleeding.
Osler-Weber-Rendu syndrome is an inherited condition. It can affect males or females of any ethnic or racial group.
People with this condition can develop abnormal blood vessels called arteriovenous malformations (AVMs) in several areas of the body. If they are on the skin, they are called telangiectasias. The AVMs can also develop in other areas of the body, such as the brain, lungs, liver, or intestines.
The syndrome is genetic, which means it results from an abnormality in one of a few genes. Scientists have identified some of the genes involved. However, they do not know exactly how the gene defects lead to the abnormal blood vessels seen in persons with this syndrome.
An experienced health care provider can detect telangiectases during a physical examination. There is often a family history of hereditary hemorrhagic telangiectasia.
Genetic testing may be available for changes (mutations) in the endoglin or ALK1 genes.
Some patients respond to estrogen therapy, which can reduce bleeding episodes. Avoid taking blood-thinning medications.
Some patients may need to take antibiotics before having dental work or surgery. Ask your doctor what precautions you should take.
HHT Foundation International -- www.hht.org
People with this syndrome can live a completely normal lifespan, depending on the parts of the body where the AVMs are located.
Call your health care provider if your child has frequent nose bleeds or other signs of this disease.
Genetic counseling is recommended for couples who want to have children and who have a family history of hereditary hemorrhagic telangiectasia. Medical treatments can prevent certain types of strokes and heart failure.
Hereditary hemorrhagic telangiectasia; HHT