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Diseases reference index «Amenorrhea - primary»

Amenorrhea is the absence of menstruation. Menstruation is a woman's monthly period.

Primary amenorrhea is when a girl has not yet started her monthly periods, and she:

  • Has gone through other normal changes that occur during puberty
  • Is older than 15

See also:

  • Menstruation - absent
  • Secondary amenorrhea


Most girls begin menstruating between ages 9 and 18, with an average around 12 years old. Primary amenorrhea typically occurs when a girl is older than 15, if she has undergone other normal changes that occur during puberty. Primary amenorrhea may occur with or without other signs of puberty.

Being born with poorly formed genital or pelvic organs (missing uterus or vagina, vaginal septum, cervical stenosis, or imperforate hymen) can lead to primary amenorrhea.

Hormones play a big role in a woman's menstrual cycle. Hormone problems can occur when:

  • Changes occur to the parts of the brain where hormones that help manage the menstrual cycle are produced
  • The ovaries are not working correctly

These problems may be due to:

  • Genetic defects
  • Infections that occur in the womb or after birth
  • Other birth defects
  • Tumors

In many cases, the cause of primary amenorrhea is not known.

Conditions associated with primary amenorrhea include:

  • Adrenogenital syndrome
  • Anorexia
  • Chromosomal abnormalities such as Turner syndrome or Sawyer syndrome
  • Congenital heart disease (cyanotic)
  • Congenital adrenal hyperplasia
  • Craniopharyngioma
  • Chronic (long-term) illnesses
  • Cushing's disease
  • Cystic fibrosis
  • Gonadal dysgenesis
  • Hypothyroidism and hyperthyroidism
  • Hypogonadotropic hypogonadism
  • Hyperprolactinemia
  • Obesity
  • Prader-Willi syndrome
  • Polycystic ovarian disease
  • Testicular feminization
  • True hermaphroditism
  • Tumors of the pituitary or adrenal glands
  • Tumors of the ovaries


A female with amenorrhea will have no menstrual flow with or without other signs of puberty.

Exams and Tests

The doctor will perform a physical exam and ask questions about your medical history. A pregnancy test will be done.

Blood tests may include:

  • Estradiol
  • FSH
  • LH
  • Prolactin
  • TSH
  • T3 and T4

Other tests that may be done include:

  • 17 hydroxyprogesterone
  • Chromosome analysis
  • Head CT
  • Head MRI scan
  • Laparoscopy
  • Pelvic ultrasound
  • Progesterone withdrawal
  • Serum progresterone


Treatment depends on the cause of the missing period. Primary amenorrhea caused by birth defects may require medications (hormones), surgery, or both.

If the amenorrhea is caused by a tumor in the brain (pituitary tumor):

  • Medications may shrink certain types of tumors.
  • Surgery to remove the tumor may also be necessary.
  • Radiation therapy is usually only performed when other treatments have not worked.

If the condition is caused by a body-wide (systemic) disease, treatment of the disease may allow menstruation to begin.

If the amenorrhea is due to low weight because of anorexia or too much exercise, periods will often begin when the weight returns to normal or the exercise level is decreased.

Outlook (Prognosis)

Overall the outlook is good, depending on the cause of the amenorrhea. If the amenorrhea is caused by one of the following conditions, there is a good chance that it can be corrected with medication, lifestyle changes, or surgery:

  • Adrenogenital syndrome
  • Chronic illness
  • Congenital heart disease
  • Drastic weight reduction
  • Hypogonadotropic hypogonadism
  • Imperforate hymen or vaginal septum
  • Malnutrition
  • Normal delay of onset (up to age 14 or 15)
  • Obesity
  • Overactive thyroid

Periods are unlikely to start on their own if the amenorrhea was caused by one of the following conditions:

  • Congenital abnormalities of the upper genital system
  • Craniopharyngioma
  • Cystic fibrosis
  • Gonadal dysgenesis
  • Prader-Willi syndrome
  • Testicular feminization syndrome
  • True hermaphroditism
  • Turner syndrome (XO)

If the amenorrhea cannot be corrected, it is sometimes possible to create a menstrual-like situation (pseudomenstruation) with medications. Medicines can help you feel more like your friends or family, and will also protect the bones from becoming too thin (osteoporosis).

Possible Complications

  • Emotional distress due to feeling different from friends or family, or worrying you might not be able to have children
  • Osteoporosis and increased risk of fractures

When to Contact a Medical Professional

Call your health provider if your daughter is older than age 16 and has not yet begun menstruating, or if she is 14 and shows no other signs of puberty.

Alternative Names

Primary amenorrhea; No periods - primary; Absent periods - primary; Absent menses - primary; Absence of periods - primary

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