Generic Name: fluphenazine (oral) (floo FEN a zeen)Brand names: Permitil, Prolixin, Prolixin Decanoate, Prolixin Enanthate
Fluphenazine is an anti-psychotic medication in a group of drugs called phenothiazines (FEEN-oh-THYE-a-zeens). It works by changing the actions of chemicals in your brain.
Fluphenazine is used to treat psychotic disorders such as schizophrenia.
Fluphenazine may also be used for other purposes not listed in this medication guide.
Before you take fluphenazine, tell your doctor if you have heart disease or high blood pressure, a history of seizures, Parkinson's disease, liver or kidney disease, severe asthma or breathing problem, past or present breast cancer, adrenal gland tumor, enlarged prostate, urination problems, glaucoma, low levels of calcium in your blood, or if you have ever had a serious side effect while using fluphenazine or similar medicines.
Before taking fluphenazine, tell your doctor about all other medications you use.
If you have certain conditions, you may need a dose adjustment or special tests to safely use this medication. Before you take fluphenazine, tell your doctor if you have:
heart disease or high blood pressure;
a history of seizures;
severe asthma, emphysema, or other breathing problem;
past or present breast cancer;
adrenal gland tumor (pheochromocytoma);
enlarged prostate or urination problems;
low levels of calcium in your blood (hypocalcemia);
if you have ever had a serious side effect while using fluphenazine or any other phenothiazine.
Tell your doctor if you will be exposed to extreme heat or cold, or to insecticide poisons while you are taking fluphenazine.It is not known whether fluphenazine is harmful to an unborn baby. Before taking this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment. Fluphenazine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Older adults may be more likely to have side effects from this medication.
Take this medication exactly as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended. Follow the directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results from this medication.
Measure liquid medicine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.
Fluphenazine oral solution concentrate solution must be mixed with at least 2 ounces (1/4 cup) of a liquid such as milk, tomato juice, fruit juice (but not apple juice), or a soft drink that does not contain caffeine.
To be sure this medication is not causing harmful effects, your liver and kidney function may need to be checked with blood tests on a regular basis. Do not miss any scheduled appointments.If you need to have any type of surgery, tell the surgeon ahead of time that you are taking fluphenazine. Do not stop using fluphenazine suddenly after long-term use, or you could have unpleasant withdrawal symptoms such as nausea, vomiting, dizziness, or feeling shaky. Talk to your doctor about how to avoid withdrawal symptoms when you stop using fluphenazine. Store fluphenazine at room temperature away from moisture, heat, and light. Do not allow liquid medicine to freeze.
See also: Fluphenazine dosage in more detail
Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.
twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs;
tremor (uncontrolled shaking), drooling, trouble swallowing, problems with balance or walking;
feeling restless, jittery, or agitated;
feeling like you might pass out;
decreased night vision, tunnel vision, watery eyes, increased sensitivity to light;
pale skin, easy bruising or bleeding, fever, sore throat, flu symptoms;
nausea and stomach pain, skin rash, and jaundice (yellowing of the skin or eyes);
high fever, stiff muscles, confusion, sweating, fast or uneven heartbeats, rapid breathing;
urinating less than usual or not at all;
joint pain or swelling with fever, swollen glands, muscle aches, chest pain, vomiting, unusual thoughts or behavior, and patchy skin color; or
slow heart rate, weak pulse, fainting, slow breathing (breathing may stop).
Less serious side effects may include:
dizziness, drowsiness, anxiety;
breast swelling or discharge;
sleep problems (insomnia), strange dreams;
blurred vision, headache;
changes in your menstrual periods;
impotence, trouble having an orgasm;
weight gain, swelling in your hands or feet;
dry mouth or a stuffy nose;
mild itching or skin rash.
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
Usual Adult Dose for Psychosis:
Oral: Initial dose: 0.5 to 10 mg/day orally in divided doses every 6 to 8 hours.Maintenance dose: A daily dose in excess of 3 mg is rarely necessary. Once symptoms have been controlled, the dosage should be gradually reduced to a daily maintenance dose of 1 to 5 mg which can often be administered as a single daily dose.Parenteral: Initial dose: 2.5 to 10 mg/day IM divided every 6 to 8 hours (2.5 mg/mL).Enanthate/Decanoate (25 mg/mL): Initial dose: 12.5 to 25 mg IM or subcutaneously.Maintenance dose: Administer enanthate/decanoate dose usually every 3 to 4 weeks.
Usual Geriatric Dose for Psychosis:
Initial dose: 1 to 2.5 mg/day orally in divided doses every 6 to 8 hours.
Also tell your doctor if you are taking any of the following medicines:
atropine (Sal-Tropine, Atreza);
lithium (Eskalith, Lithobid);
birth control pills or hormone replacement estrogens;
blood pressure medication;
a blood thinner such as warfarin (Coumadin);
certain asthma medications or bronchodilators;
insulin or diabetes medications you take by mouth;
medication for nausea, vomiting, or motion sickness;
medications to treat or prevent malaria;
medications used for general anesthesia;
medicines used to prevent organ transplant rejection;
numbing medicine such as lidocaine or Novocain;
a stimulant or ADHD medication;
ulcer or irritable bowel medications; or
medicines to treat Parkinson's disease, restless leg syndrome, or pituitary gland tumor (prolactinoma).
This list is not complete and there are many other medicines that can interact with fluphenazine. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.