Generic Name: glipizide and metformin (GLIP ih zyd and met FOR min)Brand Names: Metaglip
Glipizide and metformin is a combination of two oral diabetes medicines that help control blood sugar levels.
Glipizide and metformin is for people with type 2 diabetes who do not use daily insulin injections. This medication is not for treating type 1 diabetes.
Glipizide and metformin may also be used for other purposes not listed in this medication guide.What is the most important information I should know about glipizide and metformin?Do not use glipizide and metformin if you have congestive heart failure or kidney disease, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).
Before taking glipizide and metformin, tell your doctor if you have heart disease, liver disease, or a history of heart attack or stroke.Some people have developed a life-threatening condition called lactic acidosis while taking glipizide and metformin. Get emergency medical help if you have any of these symptoms of lactic acidosis: weakness, increasing sleepiness, slow heart rate, cold feeling, muscle pain, shortness of breath, stomach pain, feeling light-headed, and fainting.
If you need to have any type of x-ray or CT scan using a dye that is injected into your veins, you may need to temporarily stop taking glipizide and metformin. Be sure the surgeon knows ahead of time that you are using this medication.Know the signs of low blood sugar (hypoglycemia) and how to recognize them, including hunger, headache, confusion, irritability, drowsiness, weakness, dizziness, tremors, sweating, fast heartbeat, seizure (convulsions), fainting, or coma (severe hypoglycemia can be fatal). Always keep a source of sugar available in case you have symptoms of low blood sugar.What should I discuss with my healthcare provider before taking glipizide and metformin?Some people have developed a life-threatening condition called lactic acidosis while taking glipizide and metformin. Get emergency medical help if you have any of these symptoms of lactic acidosis: weakness, increasing sleepiness, slow heart rate, cold feeling, muscle pain, shortness of breath, stomach pain, feeling light-headed, and fainting.
You may be more likely to develop lactic acidosis if you have congestive heart failure.Do not use glipizide and metformin if you have congestive heart failure or kidney disease, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).
Before taking this medication, tell your doctor if you have:
liver disease; or
a history of heart attack or stroke.
If you have any of these conditions, you may need a dose adjustment or special tests to safely take glipizide and metformin.FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether glipizide and metformin passes into breast milk or if it could harm a nursing baby. Do not take glipizide and metformin without first talking to your doctor if you are breast-feeding a baby. Older adults may have a higher risk of developing lactic acidosis. Talk with your doctor about your individual risk.
Take this medication exactly as it was prescribed for you. Do not take the medication in larger or smaller amounts, or take it for longer than recommended by your doctor. Your doctor may occasionally change your dose to make sure you get the best results from this medication.Take glipizide and metformin with meals.
Glipizide and metformin is only part of a complete program of treatment that also includes diet, exercise, and weight control. It is important to use this medicine regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.
To be sure this medication is helping your condition, your blood will need to be tested on a regular basis. Your kidney function may also need to be tested. It is important that you not miss any scheduled visits to your doctor.
Your medication needs may change if you become sick or injured, if you have a serious infection, or if you have any type of surgery. Your doctor may want you to stop taking glipizide and metformin for a short time if any of these situations affect you.
Take care not to let your blood sugar get too low, causing hypoglycemia. You may have hypoglycemia if you skip a meal, exercise too long, drink alcohol, or are under stress.Know the signs of low blood sugar (hypoglycemia) and how to recognize them:
hunger, headache, confusion, irritability;
drowsiness, weakness, dizziness, tremors;
sweating, fast heartbeat;
seizure (convulsions); or
fainting, coma (severe hypoglycemia can be fatal).
Always keep a source of sugar available in case you have symptoms of low blood sugar. Sugar sources include orange juice, glucose gel, candy, or milk. If you have severe hypoglycemia and cannot eat or drink, use an injection of glucagon. Your doctor can give you a prescription for a glucagon emergency injection kit and tell you how to give the injection.
Your doctor may have you take extra vitamin B12 while you are taking glipizide and metformin. Take only the amount of vitamin B12 that your doctor has prescribed.
If you need to have any type of x-ray or CT scan using a dye that is injected into your veins, you may need to temporarily stop taking glipizide and metformin. Be sure the surgeon knows ahead of time that you are using this medication.Store glipizide and metformin at room temperature away from moisture and heat.
See also: Glipizide and metformin dosage in more detail
Take the missed dose as soon as you remember (be sure to take the medicine with food). If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.
Call your doctor at once if you have any of these serious side effects:
feeling short of breath, even with mild exertion;
pain or burning with urination;
swelling or rapid weight gain; or
increased blood pressure (severe headache, blurred vision, trouble concentrating, chest pain, numbness, seizure).
Less serious side effects may include:
sneezing, runny nose, cough or other signs of a cold;
mild nausea, vomiting, diarrhea, stomach pain; or
joint or muscle pain.
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
Usual Adult Dose for Diabetes Mellitus Type II:
Initial therapy:1 tablet (2.5 mg-250 mg) orally once or twice daily with meals.For patients with FBG 280 to 320 mg/dL:1 tablet (2.5 mg-500 mg) orally twice daily with meals.The maximum recommended daily dose is 10 mg-2000 mg per day.Previously treated patients:1 tablet (2.5 mg-500 mg) orally twice daily with meals or 1 tablet (5 mg- 500 mg) orally twice daily with meals.The maximum recommended daily dose is 20 mg-2000 mg per day.
You may be more likely to have hyperglycemia (high blood sugar) if you are taking glipizide and metformin with other drugs that raise blood sugar. Drugs that can raise blood sugar include:
diuretics (water pills);
steroids (prednisone and others);
phenothiazines (Compazine and others);
thyroid medicine (Synthroid and others);
birth control pills and other hormones;
seizure medicines (Dilantin and others); and
diet pills or medicines to treat asthma, colds or allergies.
You may be more likely to have hypoglycemia (low blood sugar) if you are taking glipizide and metformin with other drugs that lower blood sugar. Drugs that can lower blood sugar include:
aspirin or other salicylates (including Pepto-Bismol);
sulfa drugs (Bactrim and others);
a monoamine oxidase inhibitor (MAOI);
Some medications may interact with glipizide and metformin. Tell your doctor if you are using any of the following drugs:
nifedipine (Adalat, Procardia);
cimetidine (Tagamet) or ranitidine (Zantac);
amiloride (Midamor) or triamterene (Dyrenium);
morphine (MS Contin, Kadian, Oramorph);
procainamide (Procan, Pronestyl, Procanbid);
quinidine (Cardioquin, Quinidex, Quinaglute);
trimethoprim (Proloprim, Primsol, Bactrim, Cotrim, Septra);
vancomycin (Vancocin, Lyphocin); or
ketoconazole (Nizoral), itraconazole (Sporanox).
This list is not complete and there may be other drugs that can interact with glipizide and metformin. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.