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Drugs reference index «Glipizide/Metformin»

Glipizide/Metformin

Generic Name: Glipizide/Metformin (GLIP-i-zide/met-FOR-min)Brand Name: Metaglip

The metformin in this combination medicine may rarely cause a serious and sometimes fatal condition called lactic acidosis. Most of these cases have occurred in diabetic patients who also have certain kidney problems. The risk of lactic acidosis may be greater if you have liver problems, kidney problems, or heart failure. The risk may also be greater in patients who are elderly or drink alcohol. Lab tests, including kidney function, may be performed while you take Glipizide/Metformin .

Do not begin to take Glipizide/Metformin if you are over 80 years old unless lab tests show that you do not have decreased kidney function. Do not take it if you have a severe infection, have low blood oxygen levels, or are dehydrated. Tell your doctor you take Glipizide/Metformin before you have any surgery or lab procedures.

Contact your doctor right away if you notice symptoms such as fast or difficult breathing; muscle pain or tenderness; slow or irregular heartbeat; unusual drowsiness, dizziness, or lightheadedness; unusual stomach discomfort; or unusual weakness or tiredness. Contact your doctor right away if you start to feel unusually cold or if you have a general feeling of being unwell.

Glipizide/Metformin is used for:

Treating type 2 diabetes. It is used along with diet and exercise. It may be used alone or with other antidiabetic medicine.

Glipizide/Metformin is a sulfonylurea and biguanide antidiabetic combination. It works by causing the pancreas to release insulin, which helps to lower blood sugar levels. It also decreases the amount of sugar that the liver produces and the intestines absorb. It also helps to make your body more sensitive to the insulin that you naturally produce.

Do NOT use Glipizide/Metformin if:

  • you are allergic to any ingredient in Glipizide/Metformin
  • you have congestive heart failure that is treated by medicine
  • you have a severe infection, low blood oxygen levels, kidney or liver problems, or high blood ketone or acid levels (eg, diabetic ketoacidosis), or you are severely dehydrated
  • you have had a stroke or a recent heart attack, or you are in shock
  • you are 80 years old or older and have not had a kidney function test
  • you will be having surgery or certain lab procedures

Contact your doctor or health care provider right away if any of these apply to you.

Before using Glipizide/Metformin :

Some medical conditions may interact with Glipizide/Metformin . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of heart problems (eg, heart attack, heart failure), lung or breathing problems, thyroid problems, stomach or bowel problems (eg, blockage, paralysis), adrenal or pituitary problems, or lactic acidosis
  • if you have type 1 diabetes, vomiting, diarrhea, poor health or nutrition, low blood calcium or vitamin B12 levels, anemia or very poor health, or if you are dehydrated
  • if you have an infection, fever, recent injury, or moderate to severe burns
  • if you drink alcohol or have a history of alcohol abuse
  • if you have a condition called glucose 6-phosphate dehydrogenase (G6PD) deficiency
  • if you will be having surgery or certain lab procedures
  • if you take a beta-blocker (eg, propranolol)

Some MEDICINES MAY INTERACT with Glipizide/Metformin . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Beta-blockers (eg, propranolol) because the risk of low blood sugar may be increased. They may also hide certain signs of low blood sugar and make it more difficult to notice
  • Anticoagulants (eg, warfarin), azole antifungals (eg, miconazole), chloramphenicol, clofibrate, fenfluramine, insulin, monoamine oxidase inhibitors (MAOIs) (eg, phenelzine), nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen), phenylbutazone, probenecid, quinolones (eg, ciprofloxacin), salicylates (eg, aspirin), sulfonamides (eg, sulfamethoxazole), or thiazolidinediones (eg, pioglitazone) because the risk of low blood sugar may be increased
  • Calcium channel blockers (eg, nifedipine), corticosteroids (eg, prednisone) diazoxide, diuretics (eg, furosemide, hydrochlorothiazide), estrogen, hormonal contraceptives (eg, birth control pills), isoniazid, nicotinic acid, phenothiazines (eg, chlorpromazine), phenytoin, rifampin, sympathomimetics (eg, albuterol, pseudoephedrine), or thyroid hormones (eg, levothyroxine) because they may decrease Glipizide/Metformin 's effectiveness, resulting in high blood sugar
  • Gemfibrozil because blood sugar may be increased or decreased
  • Amiloride, cimetidine, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim, or vancomycin because they may increase the risk of Glipizide/Metformin 's side effects

This may not be a complete list of all interactions that may occur. Ask your health care provider if Glipizide/Metformin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Glipizide/Metformin :

Use Glipizide/Metformin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • An extra patient leaflet is available with Glipizide/Metformin . Talk to your pharmacist if you have questions about this information.
  • Take Glipizide/Metformin by mouth with food.
  • Take Glipizide/Metformin on a regular schedule to get the most benefit from it. Taking Glipizide/Metformin at the same time each day will help you remember to take it.
  • Continue to take Glipizide/Metformin even if you feel well. Do not miss any doses.
  • If you miss a dose of Glipizide/Metformin , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Glipizide/Metformin .

Important safety information:

  • Follow the diet and exercise program given to you by your health care provider.
  • Do NOT take more than the recommended dose without checking with your doctor.
  • Do not drink large amounts of alcohol while you use Glipizide/Metformin . Alcohol may increase the risk of Glipizide/Metformin 's side effects. Also, alcohol may rarely interact with Glipizide/Metformin and cause a serious reaction with symptoms such as flushing, nausea, vomiting, dizziness, or stomach pain. Talk with your doctor or health care provider before you drink alcohol while you use Glipizide/Metformin .
  • Tell your doctor or dentist that you take Glipizide/Metformin before you receive any medical or dental care, emergency care, or surgery.
  • Be careful not to become dehydrated, especially during hot weather, while you are being active, or if you have vomiting or diarrhea. Dehydration may increase your risk of side effects from Glipizide/Metformin .
  • Glipizide/Metformin contains a sulfonylurea. It may increase the risk of death from heart disease. Talk with your doctor about the benefits and risks of this or other therapies to treat your condition.
  • Carry an ID card at all times that says you have diabetes. Check your blood sugar levels as directed by your doctor. If they are often higher than they should be and you take Glipizide/Metformin exactly as prescribed, tell your doctor.
  • Glipizide/Metformin may cause low blood sugar levels. Low blood sugar may make you anxious, sweaty, weak, dizzy, drowsy, or faint. It may also make your heart beat faster; make your vision change; give you a headache, chills, or tremors; or make you more hungry. It is a good idea to carry a reliable source of glucose (eg, tablets or gel) to treat low blood sugar. If this is not available, you should eat or drink a quick source of sugar like table sugar, honey, candy, orange juice, or non-diet soda. This will raise your blood sugar level quickly. Tell your doctor right away if this happens. To prevent low blood sugar, eat meals at the same time each day and do not skip meals.
  • Risk of low blood sugar may be increased by heavy or prolonged exercise, drinking alcohol, or skipping meals.
  • Fever, infection, injury, or surgery may increase your risk for high or low blood sugar levels. If any of these occur, check your blood sugar closely and tell your doctor right away.
  • Glipizide/Metformin may commonly cause stomach upset, indigestion, nausea, vomiting, or diarrhea at the beginning of treatment. If you develop unusual or unexpected stomach problems, or if you develop stomach problems later during treatment, contact your doctor at once. This may be a sign of lactic acidosis.
  • Lab tests, including kidney function, fasting blood glucose, hemoglobin A1c, and blood counts, may be performed while you use Glipizide/Metformin . These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Glipizide/Metformin with caution in the ELDERLY; they may be more sensitive to its effects. Low blood sugar levels may also be more difficult to recognize in the elderly.
  • Glipizide/Metformin should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Glipizide/Metformin while you are pregnant. Glipizide/Metformin should not be used within 1 month before the expected delivery date because it may cause low blood sugar in the baby. It is not known if Glipizide/Metformin is found in breast milk. Do not breast-feed while taking Glipizide/Metformin .

Possible side effects of Glipizide/Metformin :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; headache; indigestion; mild stomach pain; nausea; stomach upset; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain or discomfort; confusion; dark urine; dizziness or lightheadedness; fainting; fast or difficult breathing; feeling of being unusually cold; fever, chills, or persistent sore throat; general feeling of being unwell; low blood sugar symptoms (eg, anxiety, dizziness, fast heartbeat, headache, tremors, unusual sweating); muscle pain or weakness; severe or persistent blurred vision or other vision problems; slow or irregular heartbeat; unusual drowsiness; unusual or persistent stomach pain or discomfort; unusual tiredness or weakness; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include coma; confusion; dizziness or lightheadedness; fainting; fast or difficult breathing; fast, slow, or irregular heartbeat; feeling of being unusually cold; general feeling of being unwell; muscle pain or tenderness; seizures; tremor; unusual drowsiness; unusual stomach discomfort; unusual weakness or tiredness.

Proper storage of Glipizide/Metformin :

Store Glipizide/Metformin between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Glipizide/Metformin out of the reach of children and away from pets.

General information:

  • If you have any questions about Glipizide/Metformin , please talk with your doctor, pharmacist, or other health care provider.
  • Glipizide/Metformin is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Glipizide/Metformin . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

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