Trade Names:GlucaGen- Powder for Injection 1 mg (1 unit)
Trade Names:Glucagon Emergency Kit- Powder for Injection 1 mg (1 unit)
Trade Names:Glucagon Diagnostic Kit- Powder for Injection 1 mg (1 unit)
Elevates blood glucose concentrations (by stimulating production from liver glycogen stores), relaxes smooth muscle of GI tract, decreases gastric and pancreatic secretions in GI tract, and increases myocardial contractility.
Mean C max is 1,686 pg/mL (IM). Median T max is 12.5 min (IM).
Degraded in liver, kidney, and plasma.
Mean apparent t 1/ 2 45 min (IM).
Treatment of severe hypoglycemic reactions in diabetic patients when glucose administration is not possible or during insulin shock therapy in psychiatric patients; diagnostic aid in radiologic examination of stomach, duodenum, small bowel, and colon when diminished intestinal motility would be advantageous.GlucaGen
Treatment of severe hypoglycemic reactions that may occur in patients with diabetes treated with insulin; as a diagnostic aid during radiologic examinations to temporarily inhibit movement of the GI tract.
Treatment of propranolol overdose, CV emergencies, and GI disturbances associated with spasms.
Patients with pheochromocytoma or insulinoma; hypersensitivity to any component of the product.
IM/IV 0.25 to 2 mg, depending on procedure and desired length of smooth muscle relaxation.HypoglycemiaAdults and children more than 20 kg
Subcutaneous/IM/IV 1 mg (1 unit). Do not use glucagon at concentrations above 1 mg/mL (1 unit/mL).Children less than 20 kg
Subcutaneous/IM/IV 0.5 mg (0.5 unit) or a dose equivalent to 20 to 30 mcg/kg.GlucaGen Adults and children weighing 25 kg or more
Subcutaneous/IM/IV 1 mg.Children weighing less than 25 kg or younger than 8 yr of age
Subcutaneous/IM/IV 0.5 mg. Emergency assistance should be sought if patient fails to respond within 15 min after subcutaneous or IM injection of glucagon. The glucagon injection may be repeated while waiting for emergency assistance. IV glucose must be administered if patient fails to respond to glucagon. When the patient has responded, give oral carbohydrate to restore liver glycogen and prevent recurrence of hypoglycemia.Insulin Shock TherapyAdults
Subcutaneous/IM/IV 0.5 to 1 mg after 1 h of coma (larger doses have been used to reverse coma). Patient will usually awaken in 10 to 25 min. If no response, may repeat dose.
Store unopened vials at controlled room temperature (68° to 77°F). Avoid freezing; protect from light.
May increase hypoprothrombinemic effects, possibly with bleeding.
None well documented
Transient increase in BP and pulse rate; positive inotropic and chronotropic effects (tachycardia).
Generalized allergic reactions, including urticaria, respiratory distress, and hypotension.
Monitor fingerstick blood sugars frequently in hypoglycemic patient until the patient is asymptomatic. Notify health care provider immediately if patient has not responded within 15 min of subcutaneous or IM dose of glucagon. Be prepared to administer IV glucose.BP and pulse
Monitor BP and pulse after administering glucagon. Transient increases are not uncommon. Notify health care provider immediately if increase in BP is dramatic or patient experiences symptoms. Be prepared to administer phentolamine to reduce BP in patient with pheochromocytoma or with coronary artery disease.
Category B .
Glucagon has been shown to be safe and effective.As diagnostic aid
Safety and efficacy not established.
Administer cautiously to patient with history of insulinoma or pheochromocytoma.
Glucagon is effective in treating hypoglycemia only if sufficient liver glycogen is present. Because glucagon is of little or no help in states of starvation, adrenal function impairment, or chronic hypoglycemia, treat hypoglycemia in these conditions with glucose. When using glucagon for radiologic examinations, ensure that patient is given oral carbohydrates as soon as the procedure has been completed.
Nausea, vomiting, gastric hypotonicity, diarrhea without consequential toxicity, increased BP and pulse rate.
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