Trade Names:Colace- Suppositories glycerin
Trade Names:Ophthalgan- Solution (ophthalmic) glycerin
Trade Names:Osmoglyn- Solution 50% (0.6 g glycerin/mL)
Trade Names:Pedia-Lax- Liquid 4 mL/applicator
Trade Names:Sani-Supp- Suppositories glycerin
Reduces IOP by creating osmotic gradient between plasma and ocular fluids (oral form). Promotes bowel evacuation by local irritation and hyperosmotic actions (rectal form). Reduces edema and clears corneal haze by attracting water through semipermeable corneal epithelium (ophthalmic form).
Eliminated by the kidneys.
Control of acute attack of glaucoma; reduction of IOP prior to and after ocular surgery.Rectal
Short-term treatment of constipation; to evacuate the colon for rectal and bowel examinations.Ophthalmic
Clearance of edematous corneas to facilitate ophthalmoscopic and gonioscopic examination in acute glaucoma, bullous keratitis, and Fuchs endothelial dystrophy.
Reduction of IOP and intracranial pressure via special IV preparations.
Anuria, severe dehydration, frank or impending acute pulmonary edema, severe cardiac decompensation.Rectal forms
Nausea, vomiting, acute surgical abdomen, fecal impaction, intestinal obstruction, undiagnosed abdominal pain.
PO 1 to 2 g/kg 1 to 90 min prior to surgery. PR Insert 1 suppository (3 g) or 5 to 15 mL as rectal enema and retain 15 min. Topical 1 to 2 gtt instilled in eye(s) prior to examination.Children older than 6 yr of age
PR Same as adults.Children 2 to 6 yr of age
PR 1 to 1.5 g suppository or 2 to 5 mL as rectal enema.Children younger than 2 yr of age
Use only on advice of health care provider.
Store suppositories in cool location, but do not freeze. Other formulations may be stored at room temperature.
None well documented.
None well documented.
Headache; confusion; disorientation; weakness; dizziness; fainting.
Rectal form: Perianal irritation; sweating.
Ophthalmic solution: Ocular pain and irritation.
Nausea; vomiting. Rectal form: Excessive bowel activity; abdominal cramps; bloating; flatulence.
Dehydration; hyperosmolar nonketotic coma.
Category C .
Do not administer enemas or suppositories to children younger than 2 yr of age. Safety and efficacy of other forms undetermined.
Use with caution.
Use oral form with caution in patients with hypovolemia, confused mental states, CHF, diabetes mellitus, and severe dehydration.
Copyright © 2009 Wolters Kluwer Health.