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Drugs reference index «gold sodium thiomalate»

gold sodium thiomalate

Generic Name: gold sodium thiomalate (gold SOE dee um thye OH ma late)Brand names: Myochrysine, Aurolate

What is gold sodium thiomalate?

Gold sodium thiomalate is a form of gold. Gold suppresses the inflammatory process.

Gold sodium thiomalate is used as an injection to treat adult and juvenile rheumatoid arthritis.

Gold sodium thiomalate may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about gold sodium thiomalate?

Contact your doctor immediately if you experience itching, a rash, a sore mouth, indigestion, a metallic taste in the mouth, severe or bloody diarrhea, easy bruising, or a nosebleed. These could be early signs of a toxic effect.

In rare cases, exposure to sunlight may cause areas of the skin to turn a bluish-gray color. To lessen this effect, minimize exposure to sunlight and wear a sunscreen and protective clothing when exposure to the sun is unavoidable.What should I discuss with my healthcare provider before taking gold sodium thiomalate?

Before taking gold sodium thiomalate, tell your doctor if you

  • have ever had any type of reaction to a gold compound or to any other medication;

  • have a history of bone marrow depression or blood problems;

  • have kidney disease;
  • have liver disease;
  • have congestive heart failure, high blood pressure, or any other type of heart disease;

  • have diabetes;

  • have inflammatory bowel disease;

  • have a rash; or

  • have severe lung disease.

You may not be able to take gold sodium thiomalate, or you may require a dosage adjustment or special monitoring during your therapy if you have any of these conditions.

Gold sodium thiomalate is in the FDA pregnancy category C. This means that it is not known whether gold sodium thiomalate will be harmful to an unborn baby. Gold sodium thiomalate does cross the placenta, and may accumulate in the tissue of a baby. Do not take gold sodium thiomalate without first talking to your doctor if you are pregnant or could become pregnant during treatment. Gold sodium thiomalate passes into breast milk and may affect a nursing infant. Gold sodium thiomalate is not recommended for use during breast-feeding. Do not take gold sodium thiomalate without first talking to your doctor if you are breast-feeding a baby.

How should I take gold sodium thiomalate?

Gold sodium thiomalate is given by injection. Your doctor or nurse will administer your doses, usually on a weekly basis to begin with, then every other week to monthly, depending upon your response to the medication.

You may want to lie down after injections, and your doctor will want to monitor you for side effects for 10 to 15 minutes following each shot.

Gold sodium thiomalate can cause serious side effects involving white and red blood cells. Your doctor will want to test your blood and urine before each injection to monitor any changes before they become dangerous.

Do not stop using gold sodium thiomalate without first talking to your doctor. It may take up to 3 months for you to see any effects from this medication, and it may be 6 months or more before the full benefits are realized.

What happens if I miss a dose?

Doses are given on a weekly basis. You should receive the missed dose as soon as possible, but a double dose should not be injected to make up for a missed dose.

What happens if I overdose?

Seek emergency medical attention if an overdose is suspected.

Symptoms of an gold sodium thiomalate overdose include blood in the urine, painful urination, fever, sores or ulcers in the mouth, nausea, vomiting, diarrhea, rash, and itching. A gold sodium thiomalate overdose can result in death.

What should I avoid while using gold sodium thiomalate?

In rare cases, exposure to sunlight may cause areas of the skin to turn a bluish-gray color. To lessen this effect, minimize exposure to sunlight and wear a sunscreen and protective clothing when exposure to the sun is unavoidable.

Gold sodium thiomalate side effects

Stop taking gold sodium thiomalate and seek emergency medical attention if you experience an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives).

Rarely, other serious side effects may also occur. Call your doctor immediately if you experience any of the following:

  • itching or a rash;

  • a sore mouth, indigestion, or a metallic taste in the mouth;

  • severe or bloody diarrhea;

  • easy bruising or a nosebleed;

  • yellow skin or eyes;

  • abdominal pain;

  • seizures;

  • confusion or hallucinations;

  • blood in vomit or stools;

  • blood in the urine or painful urination; or

  • shortness of breath; or

  • weakness, dizziness, nausea, vomiting, sweating, fainting, and flushing shortly after an injection.

In addition, less serious side effects may be more likely to occur. Talk to your doctor if you experience any of the following:

  • diarrhea or loose stools;

  • nausea, stomach upset, decreased appetite;

  • changes in taste; or

  • sores or ulcers in the mouth.

Arthritic symptoms may appear to worsen for 1 to 2 days following an injection and should decrease with subsequent injections.

Gold sodium thiomalate can cause serious side effects involving white and red blood cells. Your doctor will want to test your blood and urine before each injection to monitor any changes before they become dangerous.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Gold sodium thiomalate Dosing Information

Usual Adult Dose for Rheumatoid Arthritis:

Initial dose: 10 mg IM one time as a test dose.Observe for 15-30 minutes for adverse/allergic reaction.25 mg IM one week later and repeat in another week. Then 50 mg IM once a week until a cumulative dose of 1000 mg has been reached.Maintenance dose: 25 to 50 mg every other week for 2 to 20 weeks. If the clinical course remains stable, give 25 to 50 mg every third and subsequently every fourth week indefinitely.

What other drugs will affect gold sodium thiomalate?

Before using gold sodium thiomalate, tell your doctor and pharmacist about all prescription and over-the-counter medicines that you take, including vitamins, minerals, and herbal products, so that your treatment can be monitored for interactions.

Where can I get more information?

  • Your pharmacist has more information about gold sodium thiomalate written for health professionals that you may read.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2006 Cerner Multum, Inc. Version: 3.06. Revision Date: 4/12/2009 4:36:40 PM.
  • Gold Sodium Thiomalate MedFacts Consumer Leaflet (Wolters Kluwer)
  • Gold Sodium Thiomalate Professional Patient Advice (Wolters Kluwer)
  • Myochrysine Advanced Consumer (Micromedex) - Includes Dosage Information

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