Trade Names:Guanidine Hydrochloride- Tablets 125 mg
Enhances release of acetylcholine following a nerve impulse and appears to slow rates of depolarization and repolarization of muscle cell membranes.
Reduce symptoms of muscle weakness and easy fatigability associated with Lambert-Eaton syndrome.
Treatment of botulism.
PO Start with 10 to 15 mg/kg/day in 3 or 4 divided doses, gradually increasing the dose to 35 mg/kg/day or up to the development of adverse reactions.
Administer without regard to meals. Administer with food if GI upset occurs.
Store tablets at controlled room temperature (59° to 86°F).
None well documented.
None well documented.
Palpitation; tachycardia; atrial fibrillation; hypotension.
Paresthesia of lips, face, hands, and feet; cold sensations in hands and feet; nervousness; lightheadedness; increased irritability; jitteriness; tremor; trembling sensations; ataxia; emotional lability; psychotic state; confusion; mood changes; hallucination.
Rash; flushing or pink complexion; folliculitis; petechiae; purpura; ecchymosis; sweating; skin eruptions; dryness and scaling of the skin.
Dry mouth; anorexia; gastric irritation; nausea; diarrhea; abdominal cramping.
Uremia; chronic interstitial nephritis; renal tubular necrosis; acute interstitial nephritis.
Serum creatinine elevation; bone marrow suppression with anemia, leukopenia, and thrombocytopenia.
MonitorMuscle strength and function
Frequently assess muscle strength and function. Notify health care provider immediately of increasing muscle weakness and/or respiratory distress. Ensure that parenteral atropine is available for emergency treatment of cholinergic crisis.
Safety for use in pregnancy not established.
Excreted in breast milk.
Safety and efficacy not established.
Renal function may be affected in some patients.
Dose-related fatal bone marrow suppression can occur. Avoid coadministration of other drugs that may cause bone marrow suppression. Ensure that CBC with differential is obtained before starting therapy and repeated frequently during treatment.
Mild GI symptoms (eg, increased peristalsis, anorexia, diarrhea), slight numbness and tingling on the lips and fingertips, nervous hyperirritability, fibrillary tremors, convulsive muscle contractions, salivation, vomiting, hypoglycemia, circulatory disturbances.
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