Generic name: Quinapril hydrochloride, HydrochlorothiazideBrand names: Accuretic
Accuretic combines two types of blood pressure medication. The first, quinapril hydrochloride, is an ACE (angiotensin-converting enzyme) inhibitor. It works by preventing a chemical in your blood called angiotensin I from converting into a more potent form (angiotensin II) that increases salt and water retention in the body and causes the blood vessels to constrict—two actions that tend to increase blood pressure.
To aid in clearing excess water from the body, Accuretic also contains hydrochlorothiazide, a diuretic that promotes production of urine. Diuretics often wash too much potassium out of the body along with the water. However, the ACE inhibitor part of Accuretic tends to keep potassium in the body, thereby canceling this unwanted effect.
Accuretic is not used for the initial treatment of high blood pressure. It is saved for later use, when a single blood pressure medication is not sufficient for the job. In addition, some doctors are using Accuretic along with other drugs to treat congestive heart failure.
You must take Accuretic regularly for it to be effective. Since blood pressure declines gradually, it may be several weeks before you get the full benefit of Accuretic; and you must continue taking it even if you are feeling well. Accuretic does not cure high blood pressure; it merely keeps it under control.
You can take Accuretic with or without meals.
Take Accuretic exactly as prescribed, and see your doctor regularly to make sure the drug is working properly without unwanted side effects. Do not stop taking Accuretic without first consulting your doctor.
Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Accuretic.
If you are unable to urinate, avoid Accuretic.
You should not take Accuretic if you are sensitive to or have ever had an allergic reaction to any of the following: Accupril, thiazide diuretics such as hydrochlorothiazide, ACE inhibitors such as captopril and enalapril maleate, or sulfa or other sulfonamide-derived drugs such as sulfamethoxazole. If you have a history of allergies, you may be at greater risk for an allergic reaction to Accuretic. Make sure your doctor is aware of any drug reactions you have experienced.
If you develop swelling of the face, lips, tongue or throat, or of your arms and legs, or have difficulty swallowing or breathing, stop taking the medication and contact your doctor immediately. You may need emergency treatment.
If you develop abdominal pain with or without nausea and vomiting, contact your doctor. ACE inhibitors such as Accuretic have been known to cause intestinal swelling.
You may feel light-headed, especially during the first few days of Accuretic therapy. If this occurs, notify your doctor. If you actually faint, stop taking the medication until you have consulted with your doctor.
Dehydration, excessive sweating, vomiting, or diarrhea can all deplete your body's fluids and cause your blood pressure to drop. If this leads to light-headedness or fainting, you should check with your doctor.
Inform your doctor or dentist that you are taking Accuretic before undergoing surgery or anesthesia.
Do not use potassium supplements or salt substitutes containing potassium without consulting your doctor.
If you develop any type of infection such as a sore throat or fever, contact your doctor immediately. It could indicate a more serious illness.
If you are taking Accuretic, your doctor will do a complete assessment of your kidney function and will watch it closely as long as you are taking Accuretic. If you have kidney disease, Accuretic should be used with caution.
Caution is warranted, too, if you have liver disease. If you notice a yellow tinge to your skin and the whites of your eyes, stop taking the drug and notify your doctor. This could be a sign of liver damage.
Accuretic may increase your blood sugar levels if you have diabetes. It can also trigger gout or the connective tissue disease lupus erythematosus. Use Accuretic cautiously if you have any of these problems.
The safety and effectiveness of Accuretic in children have not been established.
If Accuretic is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Accuretic with the following:Barbiturates such as phenobarbitalCholestyramineColestipolCorticosteroids such as prednisone or ACTHDiabetes medications such as insulin or glyburideDigoxinDiuretics such as hydrochlorothiazideNarcotics such as acetaminophen and oxycodone hydrochlorideNonsteroidal anti-inflammatory drugs such as naproxenNorepinephrineOther high blood pressure medications such as methyldopaPotassium-sparing diuretics such as hydrochlorothiazide and spironolactone,Potassium supplements such as potassium chlorideSalt substitutes containing potassiumTetracycline
Alcohol may increase the effect of Accuretic, and could cause dizziness or fainting. Check with your doctor before drinking alcoholic beverages.
ACE inhibitors such as the one in Accuretic have been shown to cause injury and even death to the unborn child when used in pregnancy during the second and third trimesters. If you are pregnant, your doctor should discontinue Accuretic as soon as possible. If you plan to become pregnant, make sure your doctor knows you are taking Accuretic. The diuretic component of Accuretic, when taken during pregnancy, can cause jaundice (yellowing of the skin and whites of the eyes) and abnormal bruising and bleeding in newborns.
Accuretic appears in breast milk and could affect a nursing infant. Because of potential harm to the baby, you'll need to choose between breastfeeding and continuing your treatment with Accuretic.
Accuretic is usually taken once a day. Your doctor will adjust the dosage depending on how your blood pressure responds. Daily doses of up to 80 milligrams of quinapril and 50 milligrams of hydrochlorothiazide may be prescribed, but doctors aim for the smallest dose that proves effective.
Any medication taken in excess can have serious consequences. If you suspect an overdose, seek medical attention immediately.