Generic Name: hydrochlorothiazide and propranolol (HYE droe klor oh THYE a zide and proe PRAN oh lol)Brand names: Inderide, Inderide LA
Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.
Propranolol is in a group of drugs called beta-blockers. Beta-blockers affect the heart and circulation (blood flow through arteries and veins).
The combination of hydrochlorothiazide and propranolol is used to treat high blood pressure (hypertension).
Hydrochlorothiazide and propranolol may also be used for other purposes not listed in this medication guide.What is the most important information I should know about hydrochlorothiazide and propranolol?You should not use this medication if you have asthma, severe or uncontrolled heart failure, a heart condition called "sick sinus syndrome" or "AV block," or if you are unable to urinate.
Before using this medication, tell your doctor if you have congestive heart failure, kidney or liver disease, cirrhosis, bronchospastic lung disease, gout, lupus, diabetes, a thyroid disorder, or an allergy to sulfa drugs.
If you are diabetic, check your blood sugar carefully. Using propranolol can make it harder for you to tell when you have low blood sugar. Your insulin or diabetic medication needs may change while you are taking hydrochlorothiazide and propranolol. Talk with your doctor before changing any doses.Avoid drinking alcohol, which can lower your blood pressure and can increase your blood levels of propranolol.
Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.Keep using this medication even if you feel fine. High blood pressure often has no symptoms.
There are many other medicines that can interact with hydrochlorothiazide and propranolol. Tell your doctor about all the prescription and over-the-counter medications you use.What should I discuss with my doctor before taking hydrochlorothiazide and propranolol?You should not use this medication if you are allergic to hydrochlorothiazide or propranolol, or if you have:
severe or uncontrolled heart failure;
a heart condition called "sick sinus syndrome" or "AV block" (2nd or 3rd degree); or
Before using hydrochlorothiazide and propranolol, tell your doctor if you are allergic to any drugs, or if you have:
congestive heart failure;
bronchospastic lung disease;
a thyroid disorder;
if you are allergic to sulfa drugs.
Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.
Your doctor may occasionally change your dose to make sure you get the best results from this medication.Do not stop using hydrochlorothiazide and propranolol suddenly, or you could have a serious or life-threatening heart problem. Talk to your doctor about how to avoid withdrawal symptoms when stopping the medication.
To be sure this medication is not causing harmful effects, your blood pressure will need to be checked on a regular basis, and you may need blood tests. Do not miss any scheduled appointments.
Your blood and urine may both be tested if you have been vomiting or are dehydrated.
If you are diabetic, check your blood sugar carefully. Using propranolol can make it harder for you to tell when you have low blood sugar. Your insulin or diabetic medication needs may change while you are taking hydrochlorothiazide and propranolol. Talk with your doctor before changing any doses.
Hydrochlorothiazide and propranolol can affect the results of certain thyroid tests or vision tests for glaucoma. Tell any doctor who treats you that you are using this medication.If you need to have any type of surgery, tell the surgeon ahead of time that you are using hydrochlorothiazide and propranolol. You may need to stop using the medicine for a short time. Keep using hydrochlorothiazide and propranolol even if you feel fine. High blood pressure often has no symptoms. Store this medication in a tightly closed container at room temperature, away from heat and moisture.
See also: Hydrochlorothiazide and propranolol dosage in more detail
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.
Avoid using antacids without your doctor's advice. Use only the specific type of antacid your doctor recommends. Antacids contain different medicines and some types can make it harder for your body to absorb hydrochlorothiazide and propranolol.Avoid drinking alcohol, which can lower your blood pressure and can increase your blood levels of propranolol.
Avoid using other medicines that make you light-headed (especially narcotic pain medication or barbiturates). They can add to the side effects of hydrochlorothiazide and propranolol. Tell your doctor if you regularly use any of these medicines.
Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.
Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.
swelling, rapid weight gain, feeling short of breath, even with mild exertion;
fast, slow, or uneven heartbeat;
easy bruising or bleeding;
numbness or tingly feeling in your hands or feet;
feeling weak, drowsy, restless, or light-headed;
nausea, vomiting, dry mouth, extreme thirst, headache, confusion, hallucinations, seizure (convulsions);
increased urination, leg discomfort, muscle pain or weakness or limp feeling;
urinating less than usual or not at all;
fever, sore throat, and headache with a severe blistering, peeling, and red skin rash; or
upper stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Less serious side effects may include:
diarrhea, constipation, upset stomach;
dizziness, spinning sensation;
sore throat, body aches;
depressed mood; or
sleep problems (insomnia).
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
Usual Adult Dose for Hypertension:
Initial dose: 1 tablet of (hydrochlorothiazide-propranolol 25 mg/40 mg) orally once a day or1 capsule of (hydrochlorothiazide-propranolol LA 50 mg/48 mg) orally once a day.Determine dosage by individual titration.Maintenance dose: Titrate as needed to 1 tablet of (hydrochlorothiazide-propranolol 25 mg/40 mg) orally twice a day or 1 capsule of (hydrochlorothiazide-propranolol LA 50 mg/160 mg) orally once a day.
Many drugs can interact with hydrochlorothiazide and propranolol. Below is just a partial list. Tell your doctor if you are using:
insulin or diabetes medicine you take by mouth;
rifampin (Rifadin, Rifamate, Rimactane);
theophylline (Elixophyllin, Respbid, Slo-Bid, Theo-Dur, Uniphyl, and others);
steroids (prednisone and others);
other blood pressure medications, (especially reserpine);
a calcium channel blocker such as diltiazem (Tiazac, Cartia, Cardizem), felodipine (Plendil), nifedipine (Procardia, Adalat), verapamil (Calan, Covera, Isoptin, Verelan), and others; or
NSAIDs (non-steroidal anti-inflammatory drugs) such as aspirin, ibuprofen (Motrin, Advil), diclofenac (Voltaren), etodolac (Lodine), indomethacin, naproxen (Aleve, Naprosyn), and others.
This list is not complete and there may be other drugs that can interact with hydrochlorothiazide and propranolol. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.