Drugs Information Online
Drugs and diseases reference index

Drugs and diseases reference index

Drugs reference index «Immune Globulin IM (IGIM; IG; Gamma Globulin)»

Immune Globulin IM

( IGIM ; IG ; Gamma Globulin ) Pronunciation: (im-UN GLOB-u-lin)Class: Immune globulin

Trade Names:GamaSTAN S/D- Injection, solution 15% to 18% protein

GamaSTAN S/D (Canada)


Replaces normal human immunoglobulin (Ig) G antibodies.



The elimination half-life is approximately 23 days.


Approximately 2 days.

Indications and Usage

Prophylaxis of hepatitis A; prevention or modification of measles in persons exposed fewer than 6 days previously (children older than 12 mo of age who have received GamaSTAN S/D should be given measles vaccine about 3 mo later when the measles antibody titer will have disappeared); passive immunization against varicella in immunosuppressed patients; prophylaxis of rubella in pregnancy when therapeutic abortion is not an option; prevention of serious infection in patients with IgG deficiencies.


Persons with isolated IgA deficiency; patients who have severe thrombocytopenia or any coagulation disorder that would contraindicate IM injections.

Dosage and Administration

HepatitisAdults and Children

IM 0.02 mL/kg (0.01 mL/lb) for household and institutional hepatitis A case contacts.

For persons who plan to travel to areas where hepatitis is common

Administer 0.02 mL/kg if length of stay is less than 3 mo, and 0.06 mL/kg, repeated every 4 to 6 mo, if length of stay is 3 mo or longer.

IgG DeficiencyAdults and Children

IM 0.66 mL/kg (at least 100 mg/kg) every 3 to 4 wk; some patients may require more frequent injections. Administer a double dose at onset of therapy.

Postexposure Measles ProphylaxisAdults and Children

IM 0.25 mL/kg (0.11 mL/lb). To prevent or modify measles in susceptible persons exposed fewer than 6 days previously.

Susceptible Immunocompromised Children

IM 0.5 mL/kg (max, 15 mL).

Postexposure Varicella ProphylaxisAdults and Children

IM 0.6 to 1.2 mL/kg (if varicella-zoster immune globulin is unavailable).

RubellaAdults and Children

IM 0.55 mL/kg may benefit women who will not consider a therapeutic abortion.

General Advice

  • Children who are immunocompromised should not receive measles vaccine.
  • For IM administration only. Not for intradermal, subcutaneous, IV, or intra-arterial administration.
  • Divide doses larger than 10 mL and inject into several muscle sites to reduce local pain and discomfort.
  • Administer IM, preferably in the anterolateral aspects of the upper thigh and the deltoid muscle of the upper arm. The gluteal region should not be used routinely as an injection site.


Store vials in refrigerator (36° to 46°F). Do not freeze.

Drug Interactions

Live vaccines

To avoid inactivating vaccines containing live viruses or bacteria, give live vaccines approximately 3 mo after immune globulin IM, depending on dose.

Laboratory Test Interactions

None well documented.

Adverse Reactions


Anaphylactic reactions (rare), angioedema, local pain and tenderness at injection site, urticaria.



Category C .




Safety and efficacy not established.


Hypersensitivity, including anaphylaxis, may occur. Administer drug with caution in patients with prior systemic allergic reactions to human immunoglobulins.

Special Risk Patients

Administer with caution to persons receiving anticoagulant therapy because of IM administration.

Human plasma

Immune globulin is made from human plasma. Products made from human plasma may contain infectious agents, such as viruses, that can cause disease.

Patient Information

  • Instruct patient to take analgesics (eg, acetaminophen) for local pain and tenderness at injection site if necessary.
  • Provide patient or parent with immunization history record and record this injection in patient's medical records.

Copyright © 2009 Wolters Kluwer Health.

Comment «Immune Globulin IM (IGIM; IG; Gamma Globulin)»