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Drugs reference index «Indapamide»


Pronunciation: (IN-DAP-uh-mide)Class: Thiazide diuretic

Trade Names:Indapamide- Tablets 1.25 mg- Tablets 2.5 mg

Apo-Indapamide (Canada)Gen-Indapamide (Canada)Lozide (Canada)PMS-Indapamide (Canada)


Enhances excretion of sodium, chloride, and water by interfering with transport of sodium ions across renal tubular epithelium.



C max is approximately 115 to 260 ng/mL (dose-dependent). The T max is 2 h.


71% to 79% is protein bound.


Extensively metabolized.


The t ½ is 26 h. More than 70% is excreted in the urine, and 23% is excreted in the GI tract, probably including the biliary route.

Indications and Usage

Treatment of edema associated with CHF, hepatic cirrhosis, renal dysfunction, and corticosteroid or estrogen therapy; management of hypertension.

Unlabeled Uses

Treatment of calcium nephrolithiasis, osteoporosis, or diabetes insipidus.


Hypersensitivity to thiazides, related diuretics, or sulfonamide-derived drugs; anuria.

Dosage and Administration


PO 1.25 to 5 mg every morning. Maximum 5 mg/day.

General Advice

  • Administer as morning dose to prevent nocturia.
  • Give with food or milk if GI upset occurs.
  • Store in tightly closed container at room temperature.

Drug Interactions

Bile acid sequestrants

May reduce thiazide absorption; give thiazide at least 2 h before resin.


Hyperglycemia may occur.

Digitalis glycosides

Diuretic-induced hypokalemia and hypomagnesemia may precipitate digitalis-induced arrhythmias.


May decrease renal excretion of lithium; monitor lithium levels.

Loop diuretics

May result in synergistic effects and result in profound diuresis and serious electrolyte abnormalities.

Sulfonylureas, insulin

May decrease hypoglycemic effect of sulfonylureas. May need to adjust dosage of sulfonylureas or insulin.

Laboratory Test Interactions

May decrease serum protein-bound iodine levels without signs of thyroid disturbance. May cause diagnostic interference of serum electrolyte levels, blood and urine glucose levels, serum bilirubin levels and serum uric acid levels. May increase serum magnesium levels in uremic patients.

Adverse Reactions


Orthostatic hypotension; palpitations.


Dizziness; lightheadedness; vertigo; headache; weakness; restlessness; insomnia; drowsiness; fatigue; lethargy; anxiety; depression; nervousness.


Rash; necrotizing angiitis; vasculitis; cutaneous vasculitis; pruritus.


Blurred vision.


Anorexia; gastric irritation; epigastric distress; nausea; vomiting; abdominal pain/cramping/bloating; diarrhea; constipation; dry mouth.


Nocturia; impotence/reduced libido.




Hyperglycemia; glycosuria; hyperuricemia.




Muscle cramp or spasm; acute gout.



Category B .


May be excreted in breast milk.


May occur in patients with or without history of allergy or bronchial asthma; cross-sensitivity with sulfonamides may also occur.

Renal Function

May precipitate azotemia; use with caution.

Hepatic Function

Minor alterations of fluid and electrolyte balance may precipitate hepatic coma; use with caution.

Electrolyte balance

Severe hyponatremia and hypokalemia may infrequently occur with recommended doses; more common in elderly females.


May cause increased concentrations of total triglycerides and LDL in some patients.

Lupus erythematosus

Exacerbation or activation may occur.

Postsympathectomy patients

Antihypertensive effects may be enhanced.



Orthostatic or general hypotension, syncope, electrolyte abnormalities, potassium deficiency, vomiting, respiratory depression, lethargy, shock, weakness, confusion, dizziness, cramps of calf muscles, thirst, polyuria, anuria.

Patient Information

  • Tell patient to take medication early in day to prevent sleep problems.
  • Instruct patient to take drug with food or milk to minimize GI irritation.
  • Caution patient to avoid exposure to sunlight and to use sunscreen or wear protective clothing to avoid photosensitivity reaction.
  • Instruct patients with diabetes to report increased blood glucose levels.
  • Caution patients to avoid sudden position changes to prevent orthostatic hypotension.
  • Advise patients to include in diet foods that are high in potassium (eg, bananas, broccoli, dried fruits, grapefruit, lima beans, nuts, oranges).
  • Tell patient to report decrease in urinary output, jaundice, muscle cramps, weakness, nausea, blurred vision, or dizziness.
  • For patients being treated for hypertension, explain benefits of weight reduction, exercise, reduction of alcohol and sodium intake, cessation of smoking.

Copyright © 2009 Wolters Kluwer Health.

  • Indapamide MedFacts Consumer Leaflet (Wolters Kluwer)
  • Indapamide Prescribing Information (FDA)
  • Indapamide Detailed Consumer Information (PDR)
  • indapamide Concise Consumer Information (Cerner Multum)
  • indapamide Advanced Consumer (Micromedex) - Includes Dosage Information
  • Lozol Prescribing Information (FDA)

See Also...

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