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Drugs reference index «ISMO»


Generic Name: Isosorbide Mononitrate (eye-soe-SOR-bide mon-oh-NYE-trate)Brand Name: Examples include ISMO and Monoket

ISMO is used for:

Preventing angina (chest pain) caused by heart disease.

ISMO is a nitrate vasodilator. It works by widening the blood vessels in the body. This reduces the workload of the heart and helps to relieve chest pain.

Do NOT use ISMO if:

  • you are allergic to any ingredient in ISMO or to other nitrate medicines
  • you are also taking a phosphodiesterase type 5 inhibitor (eg, sildenafil, tadalafil, vardenafil)
  • you drink alcohol

Contact your doctor or health care provider right away if any of these apply to you.

Before using ISMO :

Some medical conditions may interact with ISMO . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have heart problems (eg, heart failure, heart attack, hypertrophic cardiomyopathy), low blood pressure, blood problems (eg, anemia), dehydration, bleeding the brain, an overactive thyroid, or have had a recent head injury

Some MEDICINES MAY INTERACT with ISMO . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Calcium channel blockers (eg, diltiazem, verapamil) or phosphodiesterase type 5 inhibitors (eg, sildenafil, tadalafil, vardenafil) because the risk of severe low blood pressure may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if ISMO may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use ISMO :

Use ISMO as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take ISMO by mouth with or without food.
  • This medication should be taken twice daily, with the doses 7 hours apart. The first dose should preferably be taken in the morning upon waking up, unless directed otherwise by your doctor.
  • Do not suddenly stop taking ISMO . You may have an increased risk of side effects (eg, angina attacks). If you need to stop ISMO or add a new medicine, your doctor will gradually lower your dose.
  • If you miss a dose of ISMO , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use ISMO .

Important safety information:

  • ISMO may cause dizziness or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use ISMO with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • ISMO may cause dizziness or lightheadedness; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
  • Do not drink alcohol while you are taking ISMO .
  • When you begin taking ISMO , headaches are likely to occur. Ask your doctor for instructions on ways to reduce this side effect.
  • ISMO should not be used to stop an attack of angina; it is intended only for prevention of an attack.
  • ISMO may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking ISMO .
  • ISMO should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using ISMO while you are pregnant. It is not known if ISMO is found in breast milk. If you are or will be breast-feeding while you use ISMO , check with your doctor. Discuss any possible risks to your baby.

Possible side effects of ISMO :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; headache; nausea.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); changes in vision; fainting; numbness of an arm or leg; severe stomach pain; sharp or crushing chest pain; sudden leg pain; sudden, severe headache; sudden shortness of breath; vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include breathing problems; confusion; dizziness; fainting; fever; flushing; headache; increased pressure in the head; irregular heartbeat; loss of appetite; nausea; paralysis; sweating; visual disturbances; vomiting.

Proper storage of ISMO :

Store ISMO at 59 to 86 degrees F (15 to 30 degrees C). Store away from heat, moisture, and light. Keep ISMO in the original container with the lid tightly closed. Do not store in the bathroom. Keep ISMO out of the reach of children and away from pets.

General information:

  • If you have any questions about ISMO , please talk with your doctor, pharmacist, or other health care provider.
  • ISMO is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about ISMO . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

  • Isosorbide Mononitrate Prescribing Information (FDA)
  • Isosorbide Mononitrate Professional Patient Advice (Wolters Kluwer)
  • Imdur Consumer Overview
  • Imdur Prescribing Information (FDA)
  • Ismo Advanced Consumer (Micromedex) - Includes Dosage Information
  • Ismo Prescribing Information (FDA)
  • Ismo Detailed Consumer Information (PDR)

See Also...

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