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Drugs reference index «Altoprev»

Altoprev

Generic Name: lovastatin (Oral route)

loe-va-STAT-in

Commonly used brand name(s):

In the U.S.

  • Altoprev
  • Mevacor

Available Dosage Forms:

  • Tablet
  • Tablet, Extended Release

Therapeutic Class: Antihyperlipidemic

Pharmacologic Class: HMG-COA Reductase Inhibitor

Uses For Altoprev

Lovastatin is used together with a proper diet to treat high cholesterol levels in the blood. Using this medicine may help prevent medical problems caused by such substances clogging the blood vessels. This medicine may also be used to prevent certain types of heart problems in patients with risk factors for heart problems .

Lovastatin belongs to the group of medicines called 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors. It works by blocking an enzyme that is needed by the body to make cholesterol, thereby reducing the amount of cholesterol in the blood .

Lovastatin is available only with your doctor's prescription .

Importance of Diet

Before prescribing medicine for your condition, your doctor will probably try to control your condition by prescribing a personal diet for you. Such a diet may be low in fats, sugars, and/or cholesterol. Many people are able to control their condition by carefully following their doctor's orders for proper diet and exercise. Medicine is prescribed only when additional help is needed and is effective only when a schedule of diet and exercise is properly followed .

Lovastatin should not be taken with large amounts of grapefruit juice or other grapefruit products because these may increase the concentrations of lovastatin in the body .

Before Using Altoprev

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatrics-specific problems that would limit the usefulness of lovastatin regular tablets for children aged 10 to 17 years. However, safety and efficacy in children younger than 10 years of age have not been established .

Adolescent girls taking lovastatin regular tablets should be counseled on appropriate contraceptive methods to prevent pregnancy .

Appropriate studies have not been performed on the relationship of age to the effects of lovastatin extended-release tablets in patients younger than 20 years of age. Safety and efficacy have not been established .

Geriatric

Appropriate studies performed to date have not demonstrated geriatrics-specific problems that would limit the usefulness of lovastatin in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require an adjustment in the dose for patients receiving lovastatin extended-release tablets .

Pregnancy

Pregnancy CategoryExplanation
All TrimestersXStudies in animals or pregnant women have demonstrated positive evidence of fetal abnormalities. This drug should not be used in women who are or may become pregnant because the risk clearly outweighs any possible benefit.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Atazanavir
  • Darunavir
  • Fosamprenavir
  • Itraconazole
  • Lopinavir
  • Mibefradil
  • Ritonavir
  • Tipranavir

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Amiodarone
  • Amprenavir
  • Bezafibrate
  • Ciprofibrate
  • Clarithromycin
  • Clofibrate
  • Colchicine
  • Cyclosporine
  • Dalfopristin
  • Danazol
  • Delavirdine
  • Erythromycin
  • Fenofibrate
  • Fluconazole
  • Gemfibrozil
  • Indinavir
  • Ketoconazole
  • Nefazodone
  • Nelfinavir
  • Niacin
  • Quinupristin
  • Saquinavir
  • Telithromycin
  • Verapamil

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Azithromycin
  • Bosentan
  • Diltiazem
  • Oat Bran
  • Pectin
  • St John's Wort
  • Voriconazole

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

  • Grapefruit Juice

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Alcohol abuse (or history of) or
  • Liver disease, history—Use with caution. These conditions may increase the amount of lovastatin in your blood .
  • Diabetes mellitus, uncontrolled - Use with caution.
  • Kidney disease, severe—Use with caution. This medicine may make the condition worse .
  • Liver disease, active or
  • Liver enzymes, persistently high levels—This medicine should NOT be used in these conditions. Use of this medicine may make liver problems worse .

Proper Use of lovastatin

This section provides information on the proper use of a number of products that contain lovastatin. It may not be specific to Altoprev. Please read with care.

Take this medicine only as directed by your doctor. Do not take more or less of it, and do not take more or less often than your doctor ordered .

Follow carefully the special diet your doctor gave you. This is the most important part of controlling your condition and is necessary if the medicine is to work properly .

Remember that this medicine will not cure your condition, but it does help control it. You must continue to take it as directed if you expect to keep your cholesterol levels down .

Swallow the whole. Do not crush, break, or chew it .

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For high cholesterol:
    • For oral dosage form (tablets):
      • Adults—At first, 20 milligrams (mg) once daily given with the evening meal. Your doctor may increase your dose up to a maximum of 80 mg per day if needed.
      • Children (10 to 17 years of age)—At first, 10 milligrams (mg) once daily given with the evening meal. Your doctor may increase your dose up to a maximum of 40 mg per day if needed.
      • Children (less than 10 years of age)—Use and dose must be determined by your doctor .
    • For oral dosage form (extended-release tablets):
      • Adults—At first, 20 milligrams (mg) once a day in the evening at bedtime. Your doctor may increase your dose, but the dose is usually not more than 60 mg once a day.
      • Children—Use and dose must be determined by your doctor .

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Altoprev

It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood tests may be needed to check for unwanted effects .

Your doctor will need to check your liver before you start using this medicine .

Check with your doctor immediately if you think that you may be pregnant. Do not take this medicine if you are pregnant. This medicine may cause birth defects or other problems in the baby if taken during pregnancy. Do not breastfeed while you are using this medicine .

Before having any kind of surgery (including dental surgery) or emergency treatment, tell the medical doctor or dentist in charge that you are taking this medicine .

Do not use excessive amounts of alcohol while taking lovastatin because it can worsen the adverse effects of this medicine on the liver .

Check with your doctor immediately if you experience unexplained muscle pain, tenderness, or weakness, especially if it is accompanied by unusual tiredness or fever. These may be symptoms of a muscle condition called rhabdomyolysis, which can lead to serious kidney problems .

Do not take other medicines unless thy have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements .

Altoprev Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common
  • Bladder pain
  • bloody or cloudy urine
  • chest tightness
  • cough
  • dark-colored urine
  • difficult, burning, or painful urination
  • difficulty with moving
  • fever
  • frequent urge to urinate
  • headache
  • joint pain
  • lower back or side pain
  • muscle aching, cramps, spasms, or stiffness
  • muscle pain, tenderness, or weakness
  • pain or tenderness around the eyes and cheekbones
  • shortness of breath
  • stuffy or runny nose
  • swollen joints
  • trouble with breathing
  • unusual tiredness or weakness
  • wheezing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Acid or sour stomach
  • belching
  • bloated, full feeling
  • blurred vision
  • diarrhea
  • difficulty having a bowel movement (stool)
  • dizziness
  • excess air or gas in the stomach or intestines
  • heartburn
  • indigestion
  • lack or loss of strength
  • nausea
  • passing gas
  • rash
  • stomach discomfort, upset, or pain

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

The information contained in the Thomson Healthcare (Micromedex) products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

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  • Altoprev Prescribing Information (FDA)
  • Altoprev Extended-Release Tablets MedFacts Consumer Leaflet (Wolters Kluwer)
  • Lovastatin Professional Patient Advice (Wolters Kluwer)
  • Lovastatin Prescribing Information (FDA)
  • Lovastatin Detailed Consumer Information (PDR)
  • Lovastatin MedFacts Consumer Leaflet (Wolters Kluwer)
  • Altocor Detailed Consumer Information (PDR)
  • Altocor Consumer Overview
  • Mevacor Prescribing Information (FDA)

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