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Drugs reference index «lansoprazole and naproxen»

lansoprazole and naproxen

Generic Name: lansoprazole and naproxen (lan SOE pra zole and na PROX en)Brand names: PREVACID NapraPAC 500, PREVACID NapraPAC 375

What is lansoprazole and naproxen?

Naproxen is in a group of drugs called NSAIDs (nonsteroidal anti-inflammatory drugs). It works by reducing substances in the body that cause inflammation, pain, and fever.

Lansoprazole is in a group of drugs called proton pump inhibitors. It decreases the amount of acid produced in the stomach.

The combination of lansoprazole and naproxen is used to treat symptoms of osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. The lansoprazole in this medication helps reduce the risk of stomach ulcers in people who may be at risk for them while receiving treatment with an NSAID.

Lansoprazole and naproxen may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about lansoprazole and naproxen?

The naproxen in this medicine can increase your risk of life-threatening heart or circulation problems, including heart attack or stroke. This risk will increase the longer you use naproxen. Do not use this medicine just before or after having heart bypass surgery (also called coronary artery bypass graft, or CABG).

Seek emergency medical help if you have symptoms of heart or circulation problems, such as chest pain, weakness, shortness of breath, slurred speech, or problems with vision or balance.

Naproxen can also increase your risk of serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and gastrointestinal effects can occur without warning at any time while you are taking naproxen. Older adults may have an even greater risk of these serious gastrointestinal side effects.

Call your doctor at once if you have symptoms of bleeding in your stomach or intestines. This includes black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds. Do not use any other over-the-counter pain or arthritis medication without first asking your doctor or pharmacist. Naproxen is contained in many medicines available over the counter. Read the label of any other medicine you are using to see if it contains naproxen.What should I discuss with my healthcare provider before taking lansoprazole and naproxen?Do not use this medication if you are allergic to lansoprazole (Prevacid) or naproxen (Aleve, Anaprox, Naprosyn, and others), or if you have ever had a severe allergic reaction to aspirin or other NSAIDs.

Taking an NSAID can increase your risk of life-threatening heart or circulation problems, including heart attack or stroke. This risk will increase the longer you use the NSAID. Do not use this medicine just before or after having heart bypass surgery (also called coronary artery bypass graft, or CABG).

NSAIDs can also increase your risk of serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and gastrointestinal effects can occur without warning at any time while you are taking an NSAID. Older adults may have an even greater risk of these serious gastrointestinal side effects.

If you have certain conditions, you may need a dose adjustment or special tests to safely take this lansoprazole and naproxen. Before using this medication, tell your doctor if you have:

  • liver or kidney disease;
  • heart disease, high blood pressure, or a history of stroke, heart attack, or congestive heart failure;

  • a bleeding or blood clotting disorder, such as hemophilia;

  • a history of stomach ulcers or bleeding; or

  • asthma, or a history of allergic reaction to aspirin, especially aspirin triad syndrome.

FDA pregnancy category C. It is not known whether this medication is harmful to an unborn baby. Before you take lansoprazole and naproxen, tell your doctor if you are pregnant or plan to become pregnant during treatment. Naproxen can pass into breast milk and may harm a nursing baby. It is not known whether lansoprazole passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take lansoprazole and naproxen?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Each package of this medication contains pills for 7 days of treatment (one lansoprazole capsule and two naproxen tablets per day). Follow your doctor's instructions about when to take each pill.

In most cases, you will take one lansoprazole (Prevacid) capsule and one naproxen (Naprosyn) tablet each morning before eating. The second naproxen tablet is then taken 12 hours later, without lansoprazole.

Take this medication with a full glass of water. Do not crush, chew, break, or open the lansoprazole capsule. Swallow the pill whole. It is specially made to release medicine slowly in the body. Breaking or opening the pill would cause too much of the drug to be released at one time.

To be sure this medication is not causing harmful effects, your blood will need to be tested on a regular basis. Your kidney or liver function may also need to be tested. You may also need eye exams if you have any changes in your vision. Do not miss any scheduled visits to your doctor.

This medication can cause you to have unusual results with certain medical tests. Tell any doctor who treats you that you are using naproxen.

Store this medicine at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. Symptoms of a lansoprazole and naproxen overdose may include nausea, vomiting, stomach pain or discomfort, dizziness, drowsiness, confusion, trouble breathing, and urinating less than usual or not at all.

What should I avoid while taking lansoprazole and naproxen?

Avoid taking sucralfate (Carafate) or antacids that contain magnesium or aluminum (such as Maalox, Mylanta, or Rolaids) at the same time you take lansoprazole and naproxen. These other medications can make it harder for your body to absorb lansoprazole and naproxen.

Do not use any other over-the-counter pain or arthritis medication without first asking your doctor or pharmacist. Naproxen is contained in many medicines available over the counter. If you take certain products together you may accidentally take too much naproxen. Read the label of any other medicine you are using to see if it contains naproxen. If you drink more than three alcoholic beverages per day, do not take this medication without your doctor's advice. Alcohol and naproxen together may increase the risk of bleeding in the stomach. Avoid exposure to sunlight, sunlamps, or tanning beds. Naproxen can make your skin more sensitive to sunlight, and a sunburn may result. Wear protective clothing and use sunscreen (SPF 15 or higher) when you are outdoors.

Lansoprazole and naproxen side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have any of these serious side effects:
  • chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;

  • sudden numbness or weakness, especially on one side of the body;

  • sudden headache, confusion, problems with vision, speech, or balance;

  • swelling, rapid weight gain, feeling short of breath, even with mild exertion;

  • black, bloody, or tarry stools, coughing up blood or vomit that looks like coffee grounds;

  • nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

  • fever, sore throat, and headache with a severe blistering, peeling, and red skin rash; or

  • pale skin, easy bruising, weakness.

Less serious side effects may include:

  • mild stomach pain, constipation, nausea, heartburn;

  • headache, dizziness or drowsiness;

  • sweating, mild skin rash or itching; or

  • ringing in your ears.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Lansoprazole and naproxen Dosing Information

Usual Adult Dose for Ankylosing Spondylitis:

Initial: 15 mg lansoprazole once daily with naproxen 375 mg twice daily. In the morning before eating take the lansoprazole capsule together with one tablet of naproxen 375 mg with a full glass of water, followed by naproxen 375 mg in the evening with a full glass of water.The maximum daily naproxen dose is 1000 mg.The lansoprazole capsule should be swallowed whole. Do not chew or crush.

Usual Adult Dose for Osteoarthritis:

Initial: 15 mg lansoprazole once daily with naproxen 375 mg twice daily. In the morning before eating take the lansoprazole capsule together with one tablet of naproxen 375 mg with a full glass of water, followed by naproxen 375 mg in the evening with a full glass of water.The maximum daily naproxen dose is 1000 mg.The lansoprazole capsule should be swallowed whole. Do not chew or crush.

Usual Adult Dose for Rheumatoid Arthritis:

Initial: 15 mg lansoprazole once daily with naproxen 375 mg twice daily. In the morning before eating take the lansoprazole capsule together with one tablet of naproxen 375 mg with a full glass of water, followed by naproxen 375 mg in the evening with a full glass of water.The maximum daily naproxen dose is 1000 mg.The lansoprazole capsule should be swallowed whole. Do not chew or crush.

What other drugs will affect lansoprazole and naproxen?

Tell your doctor if you are taking an antidepressant such as citalopram (Celexa), duloxetine (Cymbalta), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem, Symbyax), fluvoxamine (Luvox), paroxetine (Paxil), sertraline (Zoloft), or venlafaxine (Effexor). Taking any of these drugs with naproxen may increase your risk of stomach bleeding.

Before taking this medication, tell your doctor if you are using any of the following drugs:

  • atazanavir (Reyataz);

  • a blood thinner such as warfarin (Coumadin);

  • cholestyramine (Prevalite, Questran);

  • clopidogrel (Plavix);

  • diabetes medications you take by mouth;

  • digoxin (digitalis, Lanoxin);

  • an iron supplement;

  • lithium (Eskalith, Lithobid, others);

  • methotrexate (Rheumatrex, Trexall);

  • phenytoin (Dilantin);

  • probenecid (Benemid);

  • theophylline (Elixophyllin, Theo-24, Uniphyl);

  • steroids (prednisone and others);

  • a diuretic (water pill) such as furosemide (Lasix);

  • an antibiotic such as ampicillin (Principen) or ketoconazole (Nizoral);

  • aspirin or other NSAIDs such as ibuprofen (Motrin, Advil), naproxen (Aleve, Naprosyn), diclofenac (Voltaren), indomethacin (Indocin), ketoprofen (Orudis), and others;

  • an ACE inhibitor such as benazepril (Lotensin), captopril (Capoten), fosinopril (Monopril), enalapril (Vasotec), lisinopril (Prinivil, Zestril), quinapril (Accupril), and others; or

  • a beta-blocker such as atenolol (Tenormin), carvedilol (Coreg), labetalol (Normodyne, Trandate), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal, InnoPran), sotalol (Betapace), and others.

This list is not complete and there may be other drugs that can interact with lansoprazole and naproxen. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

  • Your pharmacist can provide more information about lansoprazole and naproxen.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2006 Cerner Multum, Inc. Version: 3.03. Revision Date: 11/17/2009 1:10:30 PM.

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