Generic Name: lapatinib (la PA tin ib)Brand Names: Tykerb
Lapatinib is a cancer medication.
Lapatinib is used together with another medicine called capecitabine (Xeloda) to treat a certain type of advanced breast cancer that has spread to other parts of the body.
Lapatinib is usually given after other cancer medications have been tried without successful treatment of symptoms.
Lapatinib may also be used for other purposes not listed in this medication guide.
Before using lapatinib, tell your doctor if you have heart disease, liver disease, or a history of "Long QT syndrome."
Lapatinib is usually taken together with another cancer medicine called capecitabine (Xeloda). Lapatinib is given once daily for 21 days in a row, and capecitabine is given twice daily for only the first 14 days in a row. This 21-day cycle is then repeated, unless your condition gets worse or you have serious side effects.
The usual dose of lapatinib is equal to 5 tablets. You may swallow each tablet one at a time, but take the entire lapatinib dose at the same time each day.Take lapatinib on an empty stomach, at least 1 hour before or 1 hour after eating.
Be sure to also read the medication guide or patient instructions for capecitabine (Xeloda).Stop using lapatinib and call your doctor at once if you have serious side effects such as severe diarrhea or vomiting, or uneven heart rate with extreme dizziness or fainting.
Before taking lapatinib, tell your doctor if you are also using antibiotics, ulcer medications, seizure medications, HIV or AIDS medications, herbal supplements, heart or blood pressure medication, or an antidepressant.
If you have certain conditions, you may need a dose adjustment or special tests to safely use this medication. Before you take lapatinib, tell your doctor if you have:
liver disease; or
a personal or family history of "Long QT syndrome."
Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.
This medication comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.
Be sure to also read the medication guide or patient instructions for capecitabine (Xeloda).Take lapatinib on an empty stomach, at least 1 hour before or 1 hour after eating.
The usual dose of lapatinib is equal to 5 tablets. You may swallow each tablet one at a time, but take the entire lapatinib dose at the same time each day.
Lapatinib is usually taken together with capecitabine in a 21-day cycle. Lapatinib is given once daily for all 21 days in a row, and capecitabine is given twice daily for only the first 14 days of the cycle. This 21-day cycle is then repeated until your doctor decides that lapatinib is no longer an appropriate treatment for your condition. Follow your doctor's instructions.Take this medication for the entire length of time prescribed by your doctor. Lapatinib is usually continued unless your condition gets worse or you have serious side effects.
To be sure this medication is not causing harmful effects, your liver function will need to be checked with blood tests on a regular basis. Do not miss any scheduled appointments.Store lapatinib at room temperature away from moisture and heat.
See also: Lapatinib dosage in more detail
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.
Symptoms of a lapatinib overdose may include severe diarrhea or vomiting.
Grapefruit and grapefruit juice may interact with lapatinib and lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor.
uneven heart rate;
extreme dizziness or fainting;
dry cough, feeling short of breath;
white patches or sores inside your mouth or on your lips; or
nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Less serious side effects may include
upset stomach, mild diarrhea;
pain or redness on the palms of your hands or the soles of your feet;
back pain; or
sleep problems (insomnia).
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Usual Adult Dose for Breast Cancer:
Initial dose: 1250 mg (5 tablets) orally once daily on days 1 through 21 continuously in combination with capecitabineLapatinib should be taken at least one hour before or one hour after a meal.Lapatinib should be taken once daily. The dose of lapatinib should not be divided.If a daily dose is missed, the patient should not double the dose the next day.Treatment should be continued until disease progression or unacceptable toxicity occurs.
Tell your doctor about all other medications you use, especially:
dexamethasone (Decadron, Hexadrol);
rifampin (Rifadin, Rifater, Rifamate, Rimactane);
St. John's wort;
an antibiotic such as clarithromycin (Biaxin) or telithromycin (Ketek);
an antifungal medication such as ketoconazole (Nizoral), itraconazole (Sporanox), or voriconazole (Vfend);
an antidepressant such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), paroxetine (Paxil), or sertraline (Zoloft);
a calcium channel blocker such as amlodipine (Norvasc), diltiazem (Tiazac, Cartia, Cardizem), felodipine (Plendil), nifedipine (Procardia, Adalat), verapamil (Calan, Covera, Isoptin, Verelan), and others;
HIV/AIDS medicine such as indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir), or saquinavir (Invirase, Fortovase); or
seizure medication such as carbamazepine (Carbatrol, Tegretol) or phenobarbital (Luminal, Solfoton).
This list is not complete and there may be other drugs that can interact with lapatinib. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.