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Drugs reference index «lapatinib»

lapatinib (Oral route)

la-PA-ti-nib

Oral routeTablet

Hepatotoxicity has been observed in clinical trials and postmarketing experience. The hepatotoxicity may be severe and deaths have been reported. Causality of the deaths is uncertain .

Hepatotoxicity has been observed in clinical trials and postmarketing experience. The hepatotoxicity may be severe and deaths have been reported. Causality of the deaths is uncertain .

Commonly used brand name(s):

In the U.S.

  • Tykerb

Available Dosage Forms:

  • Tablet

Therapeutic Class: Antineoplastic Agent

Pharmacologic Class: Tyrosine Kinase Inhibitor

Uses For lapatinib

Lapatinib belongs to the group of medicines called antineoplastics. It is used to treat advanced or metastatic breast cancer (breast cancer that has already spread) after other treatments have failed. Lapatinib is given with a second cancer medicine called capecitabine .

Lapatinib interferes with the growth of cancer cells, which are eventually destroyed. Since the growth of normal cells may also be affected by the medicine, other effects will also occur. Some of these may be serious and must be reported to your doctor. Other effects may not be serious but may cause concern .

Before you begin treatment with lapatinib, you and your doctor should talk about the good lapatinib will do as well as the risks of using it .

lapatinib is available only with your doctor's prescription .

Importance of Diet

Grapefruit and grapefruit juice may change the amount of lapatinib that is absorbed in the body. Do not eat grapefruit or drink grapefruit juice while you are using lapatinib .

Before Using lapatinib

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For lapatinib, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to lapatinib or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of lapatinib in the pediatric population. Safety and efficacy have not been established .

Geriatric

Appropriate studies performed to date have not demonstrated geriatrics-specific problems that would limit the usefulness of lapatinib in the elderly. However, elderly patients may be more sensitive to the effects of lapatinib than younger adults, which may require caution in patients receiving lapatinib .

Pregnancy

Pregnancy CategoryExplanation
All TrimestersDStudies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Using lapatinib with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Amiodarone
  • Arsenic Trioxide
  • Astemizole
  • Atazanavir
  • Carbamazepine
  • Cisapride
  • Clarithromycin
  • Dexamethasone
  • Disopyramide
  • Dofetilide
  • Droperidol
  • Gatifloxacin
  • Halofantrine
  • Ibutilide
  • Indinavir
  • Itraconazole
  • Ketoconazole
  • Levofloxacin
  • Lumefantrine
  • Mefloquine
  • Methadone
  • Moxifloxacin
  • Nefazodone
  • Nelfinavir
  • Nilotinib
  • Paliperidone
  • Pazopanib
  • Phenobarbital
  • Phenytoin
  • Pimozide
  • Procainamide
  • Quinidine
  • Quinine
  • Ranolazine
  • Rifabutin
  • Rifampin
  • Rifapentine
  • Ritonavir
  • Saquinavir
  • Sodium Phosphate
  • Sotalol
  • St John's Wort
  • Sunitinib
  • Telavancin
  • Telithromycin
  • Terfenadine
  • Tetrabenazine
  • Thioridazine
  • Vardenafil
  • Voriconazole
  • Ziprasidone

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Using lapatinib with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use lapatinib, or give you special instructions about the use of food, alcohol, or tobacco.

  • Grapefruit Juice

Other Medical Problems

The presence of other medical problems may affect the use of lapatinib. Make sure you tell your doctor if you have any other medical problems, especially:

  • Electrolyte imbalance (e.g., low magnesium or potassium in the blood) or
  • Heart disease or
  • Heart rhythm problems (e.g., QT prolongation)—May cause side effects to become worse .
  • Liver disease, severe—Patients with this condition may need a lower dose .
  • Lung disease—May make this condition worse .

Proper Use of lapatinib

lapatinib should be taken at least one hour before or one hour after a meal. All of the tablets are taken as one dose each day .

Lapatinib is given together with capecitabine. It is important that you take each medicine at the right time. Follow your doctor's instructions on when to take lapatinib .

lapatinib often causes diarrhea, nausea, and vomiting. However, it is very important that you continue to receive the medicine even if you begin to feel ill. Your doctor may give you medicine to help prevent these side effects .

Dosing

The dose of lapatinib will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of lapatinib. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (tablets):
    • For the treatment of advanced breast cancer:
      • Adults—1,250 milligrams (mg) or 5 tablets once a day for 21 days. Your doctor may tell you to repeat the 21-day cycle.
      • Children—Use and dose must be determined by your doctor .

Missed Dose

If you miss a dose of lapatinib, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using lapatinib

It is very important that your doctor check your progress at regular visits to make sure lapatinib is working properly and to check for unwanted effects .

Using lapatinib while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away .

Serious heart problems can occur with lapatinib. Check with your doctor right away if you are having fast, pounding, or irregular heartbeats, shortness of breath, or unusual tiredness or weakness .

Check with your doctor immediately if severe diarrhea occurs while taking lapatinib. You may need certain medicines to help manage and/or prevent it .

Stop using lapatinib and check with your doctor right away if you start having breathing problems, shortness of breath, cough, chest pain, fever, or chills. These could be symptoms of a serious lung disease .

lapatinib Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common
  • Difficult or labored breathing
  • fainting
  • fast or irregular heartbeat
  • severe diarrhea
  • shortness of breath
  • tightness in the chest
  • unusual tiredness or weakness
  • wheezing
Incidence not determined
  • Chest pain
  • chills
  • cough
  • fever
  • general feeling of discomfort or illness
  • thickening of bronchial secretions
  • troubled breathing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Acid or sour stomach
  • back pain
  • belching
  • cracked lips
  • diarrhea
  • difficulty with swallowing
  • dry skin
  • heartburn
  • indigestion
  • nausea
  • pain in the arms or legs
  • rash
  • redness, swelling, or painful skin
  • scaling of the skin on the hands and feet
  • sleeplessness
  • sores, ulcers, or white spots on the lips, tongue, or the inside of the mouth
  • stomach discomfort, upset, or pain
  • swelling or inflammation of the mouth
  • tingling of the hands and feet
  • trouble sleeping
  • unable to sleep
  • vomiting

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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  • Lapatinib Professional Patient Advice (Wolters Kluwer)
  • Lapatinib MedFacts Consumer Leaflet (Wolters Kluwer)
  • Tykerb Prescribing Information (FDA)
  • Tykerb Consumer Overview

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