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Drugs reference index «Letairis»

Letairis

Generic Name: Ambrisentan (am-bree-SEN-tan)Brand Name: Letairis

Letairis may cause serious liver problems. Liver function tests will be done before you start to take Letairis , and monthly while you take it. Be sure to keep all doctor and lab appointments. You should usually not take Letairis if you have abnormal liver function tests. Contact your doctor right away if you develop nausea, vomiting, loss of appetite, fever, stomach pain, yellowing of the skin or eyes, dark urine, pale stools, or unusual tiredness.

Letairis may cause serious birth defects if taken during pregnancy. Women who are pregnant should not take Letairis . Women must have a negative pregnancy test before they start to take Letairis , and monthly while they take it. They must also use 2 effective forms of birth control while they take Letairis and for 1 month after they stop taking it. Talk with your doctor about the use of effective birth control while you use Letairis .

Letairis is only available through a special program called LEAP. Talk to your doctor to be sure you are enrolled in this program and that you meet all of its requirements.

Letairis is used for:

Treating high blood pressure in the lungs (pulmonary arterial hypertension) in certain patients.

Letairis is an endothelin receptor antagonist. It works by blocking a certain substance in the lungs.

Do NOT use Letairis if:

  • you are allergic to any ingredient in Letairis
  • you are pregnant or may become pregnant
  • you have abnormal liver function tests or moderate to severe liver problems

Contact your doctor or health care provider right away if any of these apply to you.

Before using Letairis :

Some medical conditions may interact with Letairis . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of liver problems, heart problems (eg, heart failure), or blood problems (eg, anemia)
  • if you have fluid retention

Some MEDICINES MAY INTERACT with Letairis . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Azole antifungals (eg, ketoconazole), cyclosporine, fluconazole, HIV protease inhibitors (eg, ritonavir), macrolide antibiotics (eg, clarithromycin), omeprazole, or telithromycin because they may increase the risk of Letairis 's side effects
  • Rifampin because it may decrease Letairis 's effectiveness

This may not be a complete list of all interactions that may occur. Ask your health care provider if Letairis may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Letairis :

Use Letairis as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Letairis comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Letairis refilled.
  • Take Letairis by mouth with or without food.
  • Swallow Letairis whole. Do not break, crush, or chew before swallowing.
  • Take Letairis on a regular schedule to get the most benefit from it. Taking Letairis at the same times each day will help you to remember to take it.
  • Continue to take Letairis even if you feel well. Do not miss any doses.
  • If you miss a dose of Letairis , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Letairis .

Important safety information:

  • Do not take more than the recommended dose without checking with your doctor.
  • Do not stop taking Letairis unless your doctor tells you to.
  • Women who are able to become pregnant must have a negative pregnancy test before they start to take Letairis , and monthly while they are taking it. Talk with your doctor for more information.
  • Women who are able to become pregnant must use 2 effective forms of birth control while they take Letairis and for at least 1 month after they stop taking it. Talk with your doctor about the use of effective birth control while you use Letairis . Tell your doctor right away if you miss a menstrual period or think you may be pregnant.
  • Lab tests, including liver function tests and complete blood cell counts, may be performed while you use Letairis . These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Letairis with caution in the ELDERLY; they may be more sensitive to its effects, especially swelling.
  • Letairis should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: Do not use Letairis if you are pregnant. It may cause harm to the fetus. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. It is not known if Letairis is found in breast milk. Do not breast-feed while taking Letairis .

Possible side effects of Letairis :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; flushing; nose or throat irritation; stomach pain or upset; stuffy nose.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); dark urine; fever; fluid retention; irregular heartbeat; loss of appetite; nausea; pale stools; severe or persistent stomach pain; shortness of breath; sudden weight gain; swelling (eg, of the arms, legs, hands, feet); unusual bruising or bleeding; unusual tiredness or weakness; vomiting; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include fainting; lightheadedness; severe dizziness.

Proper storage of Letairis :

Store Letairis at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Letairis out of the reach of children and away from pets.

General information:

  • If you have any questions about Letairis , please talk with your doctor, pharmacist, or other health care provider.
  • Letairis is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Letairis . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

  • Letairis Prescribing Information (FDA)
  • Letairis Consumer Overview
  • Letairis Detailed Consumer Information (PDR)
  • Letairis Advanced Consumer (Micromedex) - Includes Dosage Information
  • Ambrisentan Professional Patient Advice (Wolters Kluwer)

See Also...

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