Reducing the toxic effects of methotrexate and certain other medicines (folic acid antagonists). It is also used to treat certain types of anemia (megaloblastic anemia due to folic acid deficiency) in certain patients, and it is used along with another medicine (5-fluorouracil) to prolong survival in patients with advanced colorectal cancer. It may also be used for other conditions as determined by your doctor.
Leucovorin Solution is a folic acid derivative. Methotrexate and the folic acid antagonists block the body's production of folate. Leucovorin Solution works by replacing folate in the body.
Contact your doctor or health care provider right away if any of these apply to you.
Some medical conditions may interact with Leucovorin Solution. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
Some MEDICINES MAY INTERACT with Leucovorin Solution. Tell your health care provider if you are taking any other medicines, especially any of the following:
This may not be a complete list of all interactions that may occur. Ask your health care provider if Leucovorin Solution may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
Use Leucovorin Solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Ask your health care provider any questions you may have about how to use Leucovorin Solution.
All medicines may cause side effects, but many people have no, or minor, side effects. When used in small doses, no COMMON side effects have been reported with Leucovorin Solution. Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); fainting; seizures.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately.Proper storage of Leucovorin Solution:
Store Leucovorin Solution in the refrigerator, between 36 and 46 degrees F (2 to 8 degrees C). Do not freeze. Store away from heat, moisture, and light. Do not store in the bathroom. Keep out of the reach of children and away from pets.
This information is a summary only. It does not contain all information about Leucovorin Solution. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.