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Drugs reference index «Levaquin»

Levaquin
Levaquin
Levaquin


Levaquin

Generic Name: levofloxacin (Oral route)

lee-voe-FLOX-a-sin

Oral routeTabletSolution

Fluoroquinolones, including levofloxacin, are associated with an increased risk of tendinitis and tendon rupture in all ages. This risk is further increased in older patients usually over 60 years of age, in patients taking corticosteroid drugs, and in patients with kidney, heart or lung transplants .

Fluoroquinolones, including levofloxacin, are associated with an increased risk of tendinitis and tendon rupture in all ages. Risk further increases with age over 60 years, concomitant steroid therapy, and kidney, heart, or lung transplants .

Intravenous routeSolution

Fluoroquinolones, including levofloxacin, are associated with an increased risk of tendinitis and tendon rupture in all ages. This risk is further increased in older patients usually over 60 years of age, in patients taking corticosteroid drugs, and in patients with kidney, heart or lung transplants .

Fluoroquinolones, including levofloxacin, are associated with an increased risk of tendinitis and tendon rupture in all ages. Risk further increases with age over 60 years, concomitant steroid therapy, and kidney, heart, or lung transplants .

Commonly used brand name(s):

In the U.S.

  • Levaquin

Available Dosage Forms:

  • Tablet
  • Solution

Therapeutic Class: Antibiotic

Chemical Class: Fluoroquinolone

Uses For Levaquin

Levofloxacin is used to treat bacterial infections in many different parts of the body. Levofloxacin is also used to treat anthrax and other problems as determined by your doctor.

Levofloxacin belongs to the class of medicines known as fluoroquinolone antibiotics. It works by killing bacteria or preventing their growth. However, this medicine will not work for colds, flu, or other virus infections.

This medicine is available only with your doctor's prescription.

Before Using Levaquin

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Use is not recommended for infants, children, or teenagers. However, this medicine may be used in children to prevent anthrax after possible exposure.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of levofloxacin in the elderly. However, elderly patients are more likely to have tendon disorders and kidney, liver, or heart problems which may require caution in patients receiving levofloxacin.

Pregnancy

Pregnancy CategoryExplanation
All TrimestersCAnimal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Dronedarone
  • Mesoridazine
  • Thioridazine

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acarbose
  • Acecainide
  • Acetohexamide
  • Ajmaline
  • Alosetron
  • Amiodarone
  • Asenapine
  • Azimilide
  • Benfluorex
  • Bretylium
  • Chlorpromazine
  • Chlorpropamide
  • Disopyramide
  • Dofetilide
  • Droperidol
  • Encainide
  • Flecainide
  • Fluconazole
  • Gliclazide
  • Glimepiride
  • Glipizide
  • Gliquidone
  • Glyburide
  • Guar Gum
  • Haloperidol
  • Ibutilide
  • Iloperidone
  • Insulin
  • Insulin Aspart, Recombinant
  • Insulin Glulisine
  • Insulin Lispro, Recombinant
  • Lapatinib
  • Lidocaine
  • Lumefantrine
  • Metformin
  • Methadone
  • Mexiletine
  • Miglitol
  • Moricizine
  • Nilotinib
  • Pazopanib
  • Perphenazine
  • Pirmenol
  • Prajmaline
  • Procainamide
  • Prochlorperazine
  • Propafenone
  • Quinidine
  • Ranolazine
  • Recainam
  • Sematilide
  • Sotalol
  • Sunitinib
  • Tedisamil
  • Telavancin
  • Tetrabenazine
  • Theophylline
  • Tocainide
  • Tolazamide
  • Tolbutamide
  • Trifluoperazine
  • Troglitazone
  • Warfarin
  • Ziprasidone

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Aluminum Carbonate, Basic
  • Aluminum Hydroxide
  • Aluminum Phosphate
  • Betamethasone
  • Calcium
  • Corticotropin
  • Cortisone
  • Cosyntropin
  • Deflazacort
  • Dexamethasone
  • Dihydroxyaluminum Aminoacetate
  • Dihydroxyaluminum Sodium Carbonate
  • Fludrocortisone
  • Fluocortolone
  • Hydrocortisone
  • Iron
  • Magaldrate
  • Magnesium Carbonate
  • Magnesium Hydroxide
  • Magnesium Oxide
  • Magnesium Trisilicate
  • Methylprednisolone
  • Paramethasone
  • Prednisolone
  • Prednisone
  • Triamcinolone

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Brain or spinal cord disease, including hardening of the arteries in the brain, or epilepsy or other seizures—Levofloxacin may increase the chance of convulsions (seizures) occurring and make these conditions worse.
  • Diabetes or
  • Diarrhea or
  • Heart rhythm problems (e.g., prolonged QT interval) or
  • Hypokalemia (low potassium in the blood), uncorrected—Use with caution. May make these conditions worse. .
  • Kidney disease or
  • Liver disease—Use with caution. Effects may be increased because of slower removal of levofloxacin from the body.
  • Organ transplant (e.g., kidney, heart, or lung transplant) or
  • Tendon disorder (e.g., rheumatoid arthritis), history of—Use with caution. May increase the risk of tendon problems.
  • Sensitivity of the skin to sunlight—Patients taking levofloxacin may have an increased risk of severe reactions to sunlight.

Proper Use of Levaquin

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

This medicine comes with a medication guide. Read and follow the instructions in the guide carefully. Ask your doctor if you have any questions.

Levofloxacin oral solution should be taken one hour before or two hours after eating.

Levofloxacin tablets may be taken with meals or on an empty stomach.

This medicine is best taken with a full glass (8 ounces) of water. Several additional glasses of water should be taken every day, unless you are otherwise directed by your doctor. Drinking extra water will help to prevent some unwanted effects of levofloxacin.

This medicine works best when there is a constant amount in the blood or urine. To help keep the amount constant, do not miss any doses. Also, it is best to take the doses at evenly spaced times, day and night. For example, if you are to take one dose a day, try to take it at the same time each day.

If you need to take this medicine for anthrax, your doctor will want you to begin taking it as soon as possible after you are exposed to anthrax.

If you are taking aluminum or magnesium-containing antacids, iron supplements, multivitamins, sucralfate, or zinc, do not take them at the same time that you take this medicine. It is best to take these medicines at least 2 hours before or 2 hours after taking levofloxacin. These medicines may keep levofloxacin from working properly.

Keep using this medicine for the full treatment time, even if you feel better after the first few doses. Your infection may not clear up if you stop using the medicine too soon.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage forms (oral solution or tablets):
    • For treatment of infection:
      • Adults—250 to 750 milligrams (mg) once a day.
      • Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Levaquin

If your symptoms do not improve within a few days, or if they become worse, check with your doctor.

This medicine may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and require immediate medical attention. Call your doctor right away if you have rash; itching; hives; hoarseness; shortness of breath; trouble with breathing; trouble with swallowing; or any swelling of your hands, face, or mouth after you take this medicine.

Serious skin reactions can occur with this medicine. Check with your doctor right away if you have blistering, peeling, or loosening of the skin; red skin lesions; severe acne or skin rash; sores or ulcers on the skin; or fever or chills while you are using this medicine.

Levofloxacin may cause serious liver problems, including hepatitis. Stop taking this medicine and check with your doctor right away if you start having nausea or vomiting, dark urine, light-colored stools, stomach pain, or yellow eyes or skin while you are using this medicine.

Levofloxacin may cause diarrhea, and in some cases it can be severe. Do not take any medicine to treat diarrhea without first checking with your doctor. Diarrhea medicines may make the diarrhea worse or make it last longer. If you have any questions about this or if mild diarrhea continues or gets worse, check with your doctor.

Tell your doctor right away if you or your child start having numbness, tingling, or burning pain in your hands, arms, legs, or feet. These may be symptoms of a condition called peripheral neuropathy.

For patients with low potassium levels or an abnormally slow heartbeat: Levofloxacin may increase your risk of having a fast, slow, or irregular heartbeat. Call your doctor right away if you feel that your heart is not beating normally.

Some people who take levofloxacin may become more sensitive to sunlight than they are normally. Exposure to sunlight, even for brief periods of time, may cause severe sunburn or skin rash, redness, itching, or discoloration. When you or your child begin taking this medicine:

  • Stay out of direct sunlight, especially between the hours of 10:00 a.m. and 3:00 p.m., if possible.
  • Wear protective clothing, including a hat and sunglasses.
  • Apply a sun block product that has a skin protection factor (SPF) of at least 15. Some patients may require a product with a higher SPF number, especially if they have a fair complexion. If you have any questions about this, check with your health care professional.
  • Do not use a sun lamp or tanning bed or booth.

If you have a severe reaction from the sun, check with your doctor.

Levofloxacin may cause some people to become dizzy, lightheaded, drowsy, or less alert than they are normally. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or are not alert. If these reactions are especially bothersome, check with your doctor.

Levofloxacin may rarely cause inflammation or even tearing of a tendon (the cord that attaches muscles to the bones). The risk of having tendon problems may be increased if you are over 60 years of age, using steroid medicines (e.g., dexamethasone, prednisolone, prednisone, Medrol®), if you have severe kidney problems, a history of tendon problems (e.g., rheumatoid arthritis), or if you have received an organ (e.g., heart, kidney, or lung) transplant. If you get sudden pain or swelling in a tendon after exercise (e.g., in the ankle, back of the knee or leg, shoulder, elbow, or wrist), stop using this medicine and check with your doctor right away. Refrain from exercise until your doctor says otherwise.

For diabetic patients taking insulin or diabetes medicine by mouth: Levofloxacin may cause hypoglycemia (low blood sugar) in some patients. Symptoms of low blood sugar must be treated before they lead to unconsciousness (passing out). Different people may feel different symptoms of low blood sugar. If you experience symptoms of low blood sugar, stop taking levofloxacin and check with your doctor right away:

  • Symptoms of low blood sugar can include: Anxious feeling, behavior change similar to being drunk, blurred vision, cold sweats, confusion, cool pale skin, difficulty in concentrating, drowsiness, excessive hunger, headache, nausea, nervousness, rapid heartbeat, shakiness, or unusual tiredness or weakness.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Levaquin Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Rare
  • Abdominal or stomach cramps or pain (severe)
  • abdominal or stomach tenderness
  • agitation
  • blisters
  • confusion
  • diarrhea (watery and severe) which may also be bloody
  • fever
  • hallucinations (seeing, hearing, or feeling things that are not there)
  • pain, inflammation, or swelling in the calves of the legs, shoulders, or hands
  • psychosis
  • redness and swelling of the skin
  • sensation of skin burning
  • skin rash, itching, or redness
  • trembling
Incidence not known
  • Abnormal brain wave patterns
  • black, tarry stools
  • bleeding gums
  • blurred vision
  • burning, numbness, tingling, or painful sensations
  • coma
  • confusion
  • cough
  • dark-colored urine
  • difficult with breathing
  • difficulty with swallowing
  • failure of the heart, lungs, kidneys, or liver
  • fast or irregular heartbeat
  • general body swelling
  • hives
  • hoarseness
  • increased bleeding time
  • joint or muscle pain
  • muscle cramps or spasms
  • muscle pain or stiffness
  • peeling or loosening of the skin
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • severe dizziness
  • sharp drop in blood pressure
  • shortness of breath
  • sore throat
  • swollen glands
  • tightness in the chest
  • unsteadiness or awkwardness
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • voice changes
  • weakness in the arms, hands, legs, or feet
  • wheezing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Abdominal or stomach pain or discomfort
  • change in sense of taste
  • constipation
  • diarrhea
  • dizziness
  • drowsiness
  • headache
  • lightheadedness
  • nausea
  • nervousness
  • trouble with sleeping
  • vaginal itching and discharge
  • vomiting
Incidence not known
  • Feeling faint
  • feeling of warmth or heat
  • flushing or redness of the skin, especially on the face and neck
  • sweating

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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  • Levaquin Prescribing Information (FDA)
  • Levaquin Consumer Overview
  • Levaquin Detailed Consumer Information (PDR)
  • Levaquin MedFacts Consumer Leaflet (Wolters Kluwer)
  • Levofloxacin Prescribing Information (FDA)
  • Levofloxacin Professional Patient Advice (Wolters Kluwer)

See Also...

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