Commonly used brand name(s):
In the U.S.
Available Dosage Forms:
Therapeutic Class: Methotrexate Rescue
Levoleucovorin is used as an antidote to the harmful effects of methotrexate (a cancer medicine) that is given in high doses in patients with bone cancer (osteosarcoma). It is also used to treat overdosage of certain medicines. levoleucovorin acts the same way in the body as folic acid (vitamin B-9) .
Levoleucovorin is available only with a prescription .
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For levoleucovorin, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to levoleucovorin or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies have not been performed on the relationship of age to the effects of levoleucovorin in children younger than 6 years of age. Safety and efficacy have not been established .
Appropriate studies on the relationship of age to the effects of levoleucovorin have not been performed in the geriatric population. However, no geriatrics-specific problems have been documented to date .
|All Trimesters||C||Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.|
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Using levoleucovorin with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
The presence of other medical problems may affect the use of levoleucovorin. Make sure you tell your doctor if you have any other medical problems, especially:
A nurse or other trained health professional will give you levoleucovorin. levoleucovorin is given through a needle placed in one of your veins .
It is very important that your doctor check your progress at regular visits to make sure that levoleucovorin is working properly and to check for unwanted effects .
Do not take other medicines unless they have been discussed with your doctor. This includes 5-fluorouracil (Adrucil®) and combination of trimethoprim and sulfamethoxazole (Bactrim®, Septra®). Using any of these medicines together with levoleucovorin increases your risk of serious side effects .
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:More common
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
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