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Drugs reference index «lisdexamfetamine»

lisdexamfetamine

Generic Name: lisdexamfetamine (lis dex am FET a meen)Brand Names: Vyvanse

What is lisdexamfetamine?

Lisdexamfetamine is a central nervous system stimulant. It affects chemicals in the brain and nerves that contribute to hyperactivity and impulse control.

Lisdexamfetamine is used to treat attention deficit hyperactivity disorder (ADHD) in adults and in children who are 6 to 12 years old.

Lisdexamfetamine may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about lisdexamfetamine?

Do not use lisdexamfetamine if you have used an MAO inhibitor such as isocarboxazid (Marplan), tranylcypromine (Parnate), phenelzine (Nardil), rasagiline (Azilect), or selegiline (Eldepryl, Emsam) within the past 14 days. Serious, life-threatening side effects can occur if you take lisdexamfetamine before the MAO inhibitor has cleared from your body. Do not use this medication if you are allergic to lisdexamfetamine, or if you have hardened arteries (arteriosclerosis), heart disease, moderate to severe high blood pressure (hypertension), overactive thyroid, glaucoma, severe anxiety or agitation, or a history of drug or alcohol addiction. Some stimulants have caused sudden death in children and adolescents with serious heart problems or congenital heart defects. Before taking lisdexamfetamine, tell your doctor if you have any type of heart problems. Lisdexamfetamine may be habit-forming and should be used only by the person it was prescribed for. Lisdexamfetamine should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it. Using this medication improperly can cause death or serious side effects on the heart.

What should I discuss with my doctor before taking lisdexamfetamine?

Do not use lisdexamfetamine if you have used an MAO inhibitor such as isocarboxazid (Marplan), tranylcypromine (Parnate), phenelzine (Nardil), rasagiline (Azilect), or selegiline (Eldepryl, Emsam) within the past 14 days. Serious, life-threatening side effects can occur if you take lisdexamfetamine before the MAO inhibitor has cleared from your body.

Do not use this medication if you are allergic to lisdexamfetamine or if you have:

  • heart disease or moderate to severe high blood pressure (hypertension);

  • arteriosclerosis (hardening of the arteries);

  • overactive thyroid;

  • glaucoma;

  • severe anxiety, tension, or agitation; or

  • if you have a history of drug or alcohol addiction.

Some stimulants have caused sudden death in children and adolescents with serious heart problems or congenital heart defects.

If you have any of these other conditions, you may need a dose adjustment or special tests to safely take lisdexamfetamine:

  • a congenital heart defect;

  • high blood pressure;

  • heart failure, heart rhythm disorder, or recent heart attack;

  • a personal or family history of mental illness, psychotic disorder, bipolar illness, depression, or suicide attempt;

  • epilepsy or other seizure disorder; or

  • tics (muscle twitches) or Tourette's syndrome.

FDA pregnancy category C. It is not known whether this medication is harmful to an unborn baby. However, it could cause premature birth, low birth weight, or withdrawal symptoms in a newborn if the mother takes lisdexamfetamine during pregnancy. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Lisdexamfetamine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Long-term use of lisdexamfetamine can slow a child's growth. Tell your doctor if the child using this medication is not growing or gaining weight properly.

Do not give this medication to a child younger than 6 years old without the advice of a doctor. Lisdexamfetamine may be habit-forming and should be used only by the person it was prescribed for. Lisdexamfetamine should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it. Using this medication improperly can cause death or serious side effects on the heart.

How should I take lisdexamfetamine?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results from this medication. You may also be asked to not use the medication for a day or two and watch for any differences in behavior off the medication.

Take this medication with a full glass of water.

It is best to take this medication in the morning. Do not take lisdexamfetamine in the afternoon or evening because it may cause sleep problems (insomnia).

You may take lisdexamfetamine with or without food.

The capsule should be swallowed whole. You may also open the lisdexamfetamine capsule and sprinkle the medicine into a glass of water. After the medicine has dissolved, drink this mixture right away. Do not save the mixture for later use. Discard the empty capsule.

To be sure this medication is helping your condition, your doctor will need to see you on a regular basis. Do not miss any scheduled appointments.

This medication can cause you to have unusual results with certain medical tests. Tell any doctor who treats you that you are using lisdexamfetamine.

Store lisdexamfetamine at room temperature away from moisture, heat, and light. Keep track of how many capsules have been used from each new bottle of this medicine. Lisdexamfetamine is a drug of abuse and you should be aware if any person in the household is using this medicine improperly or without a prescription.

See also: Lisdexamfetamine dosage in more detail

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, or if it is already evening, skip the missed dose and take the medicine the next morning. Taking this medicine late in the day can cause sleep problems. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. An overdose of lisdexamfetamine can be fatal.

Overdose symptoms may include restlessness, tremor, muscle twitches, rapid breathing, confusion, hallucinations, panic, aggressiveness, unexplained muscle pain or tenderness, muscle weakness, fever or flu symptoms, and dark colored urine. These symptoms may be followed by depression and tiredness. Other overdose symptoms include nausea, vomiting, diarrhea, stomach pain, uneven heartbeats, feeling light-headed, fainting, seizure (convulsions), or coma.

What should I avoid while taking lisdexamfetamine?

Lisdexamfetamine can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Avoid drinking fruit juices or taking vitamin C at the same time you take lisdexamfetamine. These can make your body absorb less of the medicine.

Lisdexamfetamine side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using lisdexamfetamine and call your doctor at once if you have any of these serious side effects:

  • fast, pounding, or uneven heartbeats;

  • decreased blood pressure (feeling light-headed, fainting);

  • dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure).

  • tremor, restlessness, hallucinations, unusual behavior, or motor tics (muscle twitches).

Less serious side effects may include:

  • nausea, vomiting, stomach pain, loss of appetite, weight loss;

  • blurred vision;

  • skin rash;

  • feeling irritable;

  • sleep problems (insomnia); or

  • dry mouth or an unpleasant taste in your mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Lisdexamfetamine Dosing Information

Usual Adult Dose for Attention Deficit Disorder:

Initial dose: 30 mg orally once a day in the morningIf necessary, the initial daily dose may be increased by 10 mg to 20 mg approximately once a week up to a maximum daily dose of 70 mg

Usual Pediatric Dose for Attention Deficit Disorder:

6 to 12 years:Initial dose: 30 mg orally once a day in the morningIf necessary, the initial daily dose may be increased by 10 mg to 20 mg approximately once a week up to a maximum daily dose of 70 mg.Lisdexamfetamine has not been studied in children under 6 years of age or adolescents. Long-term effects of amphetamines in children have not been well established. Amphetamines are not recommended for use in children under 3 years of age.

What other drugs will affect lisdexamfetamine?

Before taking lisdexamfetamine, tell your doctor if you are using any of the following drugs:

  • ammonium chloride, ascorbic acid (vitamin C), K-Phos;

  • blood pressure medications;

  • a diuretic (water pill);

  • cold or allergy medicines (antihistamines);

  • chlorpromazine (Thorazine);

  • ethosuximide (Zarontin);

  • lithium (Eskalith, Lithobid);

  • methenamine (Hiprex, Mandelamine, Urex);

  • phenytoin (Dilantin), phenobarbital (Luminal, Solfoton);

  • pain medication such as meperidine (Demerol) or propoxyphene (Darvon, Darvocet); or

  • an antidepressant such as amitriptyline (Elavil), amoxapine (Asendin), clomipramine (Anafranil), desipramine (Norpramin), imipramine (Tofranil), or nortriptyline (Pamelor).

This list is not complete and there may be other drugs that can interact with lisdexamfetamine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

  • Your pharmacist can provide more information about lisdexamfetamine.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed
  • Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2006 Cerner Multum, Inc. Version: 1.06. Revision Date: 11/17/2009 11:42:38 AM.
  • Lisdexamfetamine MedFacts Consumer Leaflet (Wolters Kluwer)
  • Vyvanse Prescribing Information (FDA)
  • Vyvanse Advanced Consumer (Micromedex) - Includes Dosage Information
  • Vyvanse Consumer Overview

See Also...

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