Ambrisentan may cause serious liver problems. Liver function tests will be done before you start to take Ambrisentan , and monthly while you take it. Be sure to keep all doctor and lab appointments. You should usually not take Ambrisentan if you have abnormal liver function tests. Contact your doctor right away if you develop nausea, vomiting, loss of appetite, fever, stomach pain, yellowing of the skin or eyes, dark urine, pale stools, or unusual tiredness.
Ambrisentan may cause serious birth defects if taken during pregnancy. Women who are pregnant should not take Ambrisentan . Women must have a negative pregnancy test before they start to take Ambrisentan , and monthly while they take it. They must also use 2 effective forms of birth control while they take Ambrisentan and for 1 month after they stop taking it. Talk with your doctor about the use of effective birth control while you use Ambrisentan .
Ambrisentan is only available through a special program called LEAP. Talk to your doctor to be sure you are enrolled in this program and that you meet all of its requirements.
Treating high blood pressure in the lungs (pulmonary arterial hypertension) in certain patients.
Ambrisentan is an endothelin receptor antagonist. It works by blocking a certain substance in the lungs.
Contact your doctor or health care provider right away if any of these apply to you.
Some medical conditions may interact with Ambrisentan . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
Some MEDICINES MAY INTERACT with Ambrisentan . Tell your health care provider if you are taking any other medicines, especially any of the following:
This may not be a complete list of all interactions that may occur. Ask your health care provider if Ambrisentan may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
Use Ambrisentan as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Ask your health care provider any questions you may have about how to use Ambrisentan .
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Constipation; flushing; nose or throat irritation; stomach pain or upset; stuffy nose.Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); dark urine; fever; fluid retention; irregular heartbeat; loss of appetite; nausea; pale stools; severe or persistent stomach pain; shortness of breath; sudden weight gain; swelling (eg, of the arms, legs, hands, feet); unusual bruising or bleeding; unusual tiredness or weakness; vomiting; yellowing of the skin or eyes.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include fainting; lightheadedness; severe dizziness.Proper storage of Ambrisentan :
Store Ambrisentan at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Ambrisentan out of the reach of children and away from pets.
This information is a summary only. It does not contain all information about Ambrisentan . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.