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Generic Name: amikacin (am E kay sin)Brand Names: Amikin, Amikin Pediatric
Amikacin is an antibiotic. It fights bacteria in the body.
Amikacin is used to treat severe or serious bacterial infections.
Amikacin may also be used for purposes other than those listed in this medication guide.
If you are injecting amikacin at home, your healthcare provider will give you detailed instructions on how and where to inject the medication. If you do not understand these directions, do not attempt to inject the medication. Contact your healthcare provider for further instructions.
Amikacin may cause damage to the kidneys and/or nerves. Kidney function and drug levels in the blood may be monitored with blood tests during treatment. Tell your doctor if you experience hearing loss, dizziness, numbness, skin tingling, muscle twitching, or seizures which may be signs of nerve damage.
sulfite sensitivity;
hearing loss or loss of balance due to ear problems;
Parkinson's disease; or
a neuromuscular disorder such as myasthenia gravis.
You may not be able to use amikacin, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.
Do not use amikacin without first talking to your doctor if you are pregnant or could become pregnant during treatment. Do not use amikacin without first talking to your doctor if you are breast-feeding a baby.If you are injecting amikacin at home, your healthcare provider will give you detailed instructions on how and where to inject the medication. If you do not understand these directions, do not attempt to inject the medication. Contact your healthcare provider for further instructions.
Do not use any amikacin that is discolored, has particles in it, or looks different from your previous doses. Throw away any unused amikacin after the amount of time determined by your pharmacist or doctor.
Adequate hydration is important during treatment with amikacin. Fluids may be administered intravenously during treatment.
It is important that the medication be given on a regular schedule and for the entire amount of time prescribed by your doctor.
Amikacin may cause damage to the kidneys and/or nerves. Kidney function and drug levels in the blood may be monitored with blood tests during treatment. Tell your doctor if you experience hearing loss, dizziness, numbness, skin tingling, muscle twitching, or seizures which may be signs of nerve damage.
Dispose of used needles and syringes in a puncture resistant container out of the reach of children.
Your healthcare provider will store amikacin as directed by the manufacturer or give you detailed storage instructions if you are storing the medication at home.
Contact your doctor if a dose is missed.
Contact your doctor or seek emergency medical attention if an overdose is suspected. An overdose of the medication may result in damage to the kidneys or hearing loss, dizziness, numbness, skin tingling, muscle twitching, or seizures (which may be signs of nerve damage).
There are no restrictions on food, beverages, or activity while taking amikacin unless otherwise directed by your doctor.
an allergic reaction (shortness of breath; closing of the throat; hives; swelling of the lips, face, or tongue; rash; or fainting);
little or no urine;
decreased hearing or ringing in the ears;
dizziness, clumsiness, or unsteadiness;
numbness, skin tingling, muscle twitching, or seizures; or
severe watery diarrhea and abdominal cramps.
Other, less serious side effects may be more likely to occur. Continue to take amikacin and talk to your doctor if you experience
increased thirst;
loss of appetite;
nausea or vomiting;
a rash.
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.
Usual Adult Dose for Bacteremia:
15 to 22.5 mg/kg/day IV or IM in 1 to 3 divided doses, depending on severity of infection (initial maximum of 1.5 g/day, then adjust dose based on desired serum levels)
Usual Adult Dose for Intraabdominal Infection:
15 to 22.5 mg/kg/day IV or IM in 1 to 3 divided doses, depending on severity of infection (initial maximum of 1.5 g/day, then adjust dose based on desired serum levels)
Usual Adult Dose for Joint Infection:
15 to 22.5 mg/kg/day IV or IM in 1 to 3 divided doses, depending on severity of infection (initial maximum of 1.5 g/day, then adjust dose based on desired serum levels)
Usual Adult Dose for Osteomyelitis:
15 to 22.5 mg/kg/day IV or IM in 1 to 3 divided doses, depending on severity of infection (initial maximum of 1.5 g/day, then adjust dose based on desired serum levels)
Usual Adult Dose for Pneumonia:
15 to 22.5 mg/kg/day IV or IM in 1 to 3 divided doses, depending on severity of infection (initial maximum of 1.5 g/day, then adjust dose based on desired serum levels)
Usual Adult Dose for Skin or Soft Tissue Infection:
15 to 22.5 mg/kg/day IV or IM in 1 to 3 divided doses, depending on severity of infection (initial maximum of 1.5 g/day, then adjust dose based on desired serum levels)
Usual Adult Dose for Cystic Fibrosis:
Higher doses may be required for the treatment of Pseudomonas aeruginosa pulmonary infections in cystic fibrosis patients. Dosing should be individualized and based on serum concentrations. Doses of up to 35 mg/kg/day once daily by IV infusion or in divided doses every 6 to 8 hours have been reported.
Usual Adult Dose for Febrile Neutropenia:
Higher doses may be required. Dosing should be individualized and based on serum concentrations. Doses of up to 15 to 30 mg/kg/day IV in 1 to 3 divided doses have been reported in conjunction with a beta-lactam antibiotic (initial maximum of 1.5 g/day, then adjust dose based on desired serum levels).
Usual Adult Dose for Meningitis:
IV or IM: 15 to 22.5 mg/kg/day in 1 to 3 divided doses, depending on severity of infection (initial maximum of 1.5 g/day, then adjust dose based on desired serum levels)Intrathecal: 0.1 mg per mL of CSF or approximately 2 mg/kg body weight per day has been used to treat gram-negative bacillary meningitis in conjunction with parenteral antibiotics
Usual Adult Dose for Nosocomial Pneumonia:
20 mg/kg /day IV in 1 to 3 divided dosesInitial empiric treatment with broad-spectrum coverage according to the hospital's and/or ICU's antibiogram is recommended if multidrug-resistant organisms are suspected.Duration: If the causative organism is not Pseudomonas aeruginosa, the duration of treatment should be as short as clinically possible (e.g., as little as 7 days) to reduce the risk of superinfections with resistant organisms.
Usual Adult Dose for Peritonitis:
Peritoneal dialysis-related peritonitis: CAPD intermittent dosing: 2 mg/kg in 1 exchange/day (based on ideal body weight) intraperitoneally for anuric patients and 2.5 mg/kg/bag for nonanuric patients (investigational)CAPD continuous dosing: 24 mg/L exchange intraperitoneally for anuric patients and 30 mg/L for nonanuric patientsMaximum dose: 1.5 g/day by all routes
Usual Adult Dose for Tuberculosis -- Active:
15 mg/kg (maximum 1 g) IM or IV every 24 hoursMay be given in combination with at least 3 other active drugs for treatment of multi-drug resistant TB, or when the patient is intolerant of first-line agents. AFB smear and culture should be monitored monthly.Duration: Treatment for TB should generally continue for 18 to 24 months, or for 12 to 18 months after culture results are negative.
Usual Adult Dose for Urinary Tract Infection:
Uncomplicated: 250 mg IV or IM every 12 hoursAmikacin is not recommended for mild to moderate infections.
Usual Pediatric Dose for Febrile Neutropenia:
1 to 18 years: Higher doses may be required. Dosing should be individualized and based on serum concentrations. Doses ranging from 15 to 30 mg/kg/day in 1 to 3 divided doses have been reported in conjunction with a beta-lactam antibiotic.
Usual Pediatric Dose for Cystic Fibrosis:
1 to 18 years: Higher doses and/or more frequent intervals may be required. Dosing should be individualized and based on serum concentrations. Doses of up to 35 mg/kg/day IV in 1 to 3 divided doses have been reported.
Usual Pediatric Dose for Peritonitis:
Peritoneal dialysis-related peritonitis: 17 years or less:Initial dose: 25 mg/L dialysate intraperitoneallyMaintenance dose: 12 mg/L dialysateMaximum dose: 1.5 g/day by all routes
Usual Pediatric Dose for Tuberculosis -- Active:
15 to 30 mg/kg (maximum 1 g) IM or IV every 24 hoursMay be given in combination with at least 3 other active drugs for treatment of multi-drug resistant TB, or when the patient is intolerant of first-line agents. AFB smear and culture should be monitored monthly.Duration: Treatment for TB should generally continue for 18 to 24 months, or for 12 to 18 months after culture results are negative.
Other drugs, especially those that affect the kidneys, can interact with amikacin resulting in dangerous side effects and/or decreased effectiveness. Do not take any other prescription or over-the-counter medicines, including vitamins, minerals, and herbal products, without first talking to your doctor during treatment with amikacin.