Commonly used brand name(s):
In the U.S.
Available Dosage Forms:
Therapeutic Class: Antimalarial
Mefloquine is used to treat malaria. It is also used to prevent malaria infection in areas or regions where it is known that other medicines (e.g., chloroquine) may not work.
Mefloquine belongs to a group of medicines known as antimalarials. It works by preventing or treating malaria, a red blood cell infection transmitted by the bite of a mosquito.
Malaria transmission occurs in large areas of Central and South America, Hispaniola, sub-Saharan Africa, the Indian subcontinent, Southeast Asia, the Middle East, and Oceania. Country-specific information on malaria can be obtained from the Centers for Disease Control and Prevention (CDC), or from the CDC's web site at http://www.cdc.gov/travel.
mefloquine is available only with your doctor's prescription.
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For mefloquine, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to mefloquine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of mefloquine in children. However, safety and efficacy have not been established in infants up to 6 months old.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of mefloquine in the elderly. However, elderly patients are more likely to have age-related heart problems, which may require caution in patients receiving mefloquine.
|All Trimesters||C||Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.|
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Using mefloquine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
Using mefloquine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Using mefloquine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
The presence of other medical problems may affect the use of mefloquine. Make sure you tell your doctor if you have any other medical problems, especially:
Take mefloquine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.
mefloquine comes with a medication guide and an information wallet card. Read and follow the instructions carefully. Talk with your doctor if you have any questions.
Mefloquine is best taken with a full glass (8 ounces) of water and with food, unless otherwise directed by your doctor.
Mefloquine may be crushed and put in water, milk, or juice to make it easier to take.
For patients taking mefloquine to prevent the symptoms of malaria:
Keep using mefloquine for the full treatment time, even if you feel better after the first few doses. Your infection may not clear up if you stop using the medicine too soon.
Children may vomit after taking mefloquine. Your child may vomit some of the dose of medicine. Contact your child's doctor if vomiting occurs. The doctor may need for you to give your child more medicine.
The number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on whether you are using mefloquine to prevent or to treat malaria.
The dose of mefloquine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of mefloquine. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
If you miss a dose of mefloquine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Ask your healthcare professional how you should dispose of any medicine you do not use.
It is important that your doctor check your progress after treatment. This is to make sure that the infection is cleared up completely, and to allow your doctor to check for any unwanted effects. Blood tests may be needed to check for unwanted effects.
If your symptoms do not improve within a few days, or if they become worse, check with your doctor.
Do not take halofantrine (Halfan®) or ketoconazole (Nizoral®) with mefloquine or within 15 weeks after the last dose of mefloquine. This may increase the risk for more serious problems.
mefloquine can cause changes in heart rhythms, such as a condition called QT prolongation. It may change the way your heart beats and cause fainting or serious side effects in some patients. Call your doctor right away if you have any symptoms of heart rhythm problems, such as fast, pounding, or irregular heartbeats.
Check with your doctor right away if you have flu-like symptoms (such as chills, fever, headache, or muscle pains) again after treatment with mefloquine.
Use birth control pills while you are taking mefloquine and for 3 months after you stop mefloquine therapy. If you think you have become pregnant while using mefloquine, tell your doctor right away.
mefloquine may cause serious allergic reactions. Call your doctor right away if you have a rash; itching; hives; hoarseness; trouble with breathing; trouble with swallowing; or any swelling of your hands, face, or mouth while you are using mefloquine.
Mefloquine may cause vision problems. It may also cause some people to become dizzy or lightheaded or to have hallucinations (seeing, hearing, or feeling things that are not there). Make sure you know how you react to mefloquine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or are not alert or able to see well. This is especially important for people whose jobs require fine coordination. If these reactions are especially bothersome, check with your doctor.
Check with your doctor immediately if blurred vision, difficulty in reading, or any other change in vision occurs during or after treatment. Your doctor may want you to have your eyes checked by an ophthalmologist (eye doctor).
While you are being treated with mefloquine, do not have any immunizations (vaccinations) without your doctor's approval. Live virus vaccines should be completed 3 days before the first dose of mefloquine.
Malaria is spread by the bites of certain kinds of infected female mosquitoes. If you are living in or will be traveling to an area where there is a chance of getting malaria, the following mosquito-control measures will help to prevent infection:
Do not take other medicines unless they have been discussed with your doctor (especially medicines that prolong QT interval). This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:Rare
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
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