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Drugs reference index «megestrol»

megestrol


megestrol

Generic Name: megestrol (meh JESS trol)Brand names: Megace, Megace ES

What is megestrol?

Megestrol is a man-made chemical similar to the female hormone progesterone.

Megestrol is used to treat loss of appetite and weight loss because of disease. Megestrol is also used in the treatment of advanced breast cancer and endometrial cancer.

Megestrol may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about megestrol?

Notify your doctor if you develop any side effects while taking megestrol.

What should I discuss with my healthcare provider before taking megestrol?

Before taking megestrol, tell your doctor if you have

  • diabetes or

  • a history of blood clots.

You may not be able to take megestrol, or you may require a lower dose or special monitoring during treatment if you have either of the conditions listed above.

Do not take this medication if you are pregnant or are planning a pregnancy. Megestrol is in the FDA pregnancy category X. This means that megestrol is known to cause birth defects. Megestrol may cause abnormal development of the sexual organs. Megestrol may pass into breast milk and harm a nursing infant. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.

How should I take megestrol?

Take megestrol exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each pill with a full glass of water. Shake the suspension form of megestrol well before measuring a dose. To ensure that you get a correct dose, measure the suspension with a dose-measuring spoon or cup, not a regular tablespoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one. Store megestrol at room temperature away from moisture and heat.

See also: Megestrol dosage in more detail

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the dose you missed and take only your next regularly scheduled dose, as directed. Do not take a double dose of this medication unless otherwise directed by your doctor.

What happens if I overdose?

A megestrol overdose is unlikely to threaten life. Call an emergency room or poison control center for advice.

Symptoms of a megestrol overdose are not known.

What should I avoid while taking megestrol?

There are no restrictions on food, beverages, or activity during treatment with megestrol unless your doctor directs otherwise.

Megestrol side effects

Stop taking megestrol and seek emergency medical attention or call your doctor immediately if you experience any of the following serious side effects:
  • an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);

  • sudden severe headache;

  • changes in vision; or

  • numbness or swelling in an arm or leg.

Other, less serious side effects may be more likely to occur. Notify your doctor if you experience

  • nausea or vomiting,

  • dizziness,

  • mild shortness of breath;

  • weakness,

  • headache,

  • menstrual bleeding,
  • hot flashes or sweating,

  • decreased sex drive, or

  • insomnia.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

Megestrol Dosing Information

Usual Adult Dose for Breast Cancer--Palliative:

Megestrol tablets are indicated for use in the palliative treatment of advanced carcinoma of the breast: 160 mg/day (40 mg of oral tablets four times a day)

Usual Adult Dose for Endometrial Carcinoma:

Megestrol tablets are indicated for use in the palliative treatment of advanced carcinoma of the endometrium: 40 to 320 mg/day of oral tablets in divided doses

Usual Adult Dose for Anorexia:

Megestrol oral suspension is indicated for use in the treatment of anorexia at a dose of 800 mg/day.Alternatively, 625 mg/5 mL of the concentrated formula (Megace ES formula) may be given.Note: 800 mg/20 mL of the regular formula is equivalent to 625 mg/ 5 mL of the concentrated formula.

Usual Adult Dose for Cachexia:

Megestrol oral suspension is indicated for use in the treatment of cachexia at a dose of 800 mg/day.Alternatively, 625 mg/5 mL of the concentrated formula (Megace ES formula) may be given.Note: 800 mg/20 mL of the regular formula is equivalent to 625 mg/ 5 mL of the concentrated formula.

Usual Adult Dose for Weight Loss:

Megestrol oral suspension is indicated for use in the treatment of unexplained, significant weight loss in patients with a diagnosis of acquired immunodeficiency syndrome (AIDS) at a dose of 800 mg/day.Alternatively, 625 mg/5 mL of the concentrated formula (Megace ES formula) may be given.Note: 800 mg/20 mL of the regular formula is equivalent to 625 mg/ 5 mL of the concentrated formula.

Usual Adult Dose for Abnormal Uterine Bleeding:

5 to 10 mg/day for 5 to 10 days

What other drugs will affect megestrol?

Before taking megestrol, tell your doctor if you are taking insulin or an oral diabetes medicine such as glipizide (Glucotrol), glyburide (Diabeta, Micronase, Glynase), chlorpropamide (Diabinese), tolazamide (Tolinase), or tolbutamide (Orinase). Megestrol may decrease the effects of these medications, and your blood sugar level may increase. If you have diabetes, monitor your blood sugar and talk to your doctor if you notice any unusual changes.

Drugs other than those listed here may also interact with megestrol. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Where can I get more information?

  • Your pharmacist has additional information about megestrol written for health professionals that you may read.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2006 Cerner Multum, Inc. Version: 2.02. Revision Date: 4/12/2009 4:39:44 PM.
  • Megestrol MedFacts Consumer Leaflet (Wolters Kluwer)
  • Megestrol Prescribing Information (FDA)
  • Megace Prescribing Information (FDA)
  • Megace Advanced Consumer (Micromedex) - Includes Dosage Information
  • Megace Suspension MedFacts Consumer Leaflet (Wolters Kluwer)
  • Megace ES Prescribing Information (FDA)
  • Megace ES Suspension MedFacts Consumer Leaflet (Wolters Kluwer)
  • Megace ES Detailed Consumer Information (PDR)
  • Megace ES Consumer Overview

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