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Drugs reference index «meloxicam»

meloxicam


meloxicam (Oral route)

mel-OX-i-kam

Oral routeSuspensionTablet

NSAIDs may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. This risk may increase with duration of use. Patients with cardiovascular disease or risk factors for cardiovascular disease may be at greater risk.

Meloxicam is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery.

NSAIDs cause an increased risk of serious gastrointestinal adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients are at greater risk for serious gastrointestinal events .

NSAIDs may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. This risk may be increased in patients with cardiovascular disease or risk factors for cardiovascular disease. Meloxicam is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery. NSAIDs can also cause an increased risk of serious gastrointestinal adverse events especially in the elderly, including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal .

Commonly used brand name(s):

In the U.S.

  • Mobic

Available Dosage Forms:

  • Tablet
  • Suspension

Therapeutic Class: Analgesic

Pharmacologic Class: NSAID

Chemical Class: Oxicam

Uses For meloxicam

Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve symptoms of arthritis (juvenile rheumatoid arthritis, osteoarthritis, and rheumatoid arthritis), such as inflammation, swelling, stiffness, and joint pain. However, meloxicam does not cure arthritis and will only help you as long as you continue to take it.

meloxicam is available only with your doctor's prescription.

Before Using meloxicam

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For meloxicam, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to meloxicam or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of meloxicam in children with juvenile rheumatoid arthritis older than 2 years of age.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of meloxicam in the elderly. Caution should be used in elderly patients who are taking meloxicam because they may be at greater risk for serious gastrointestinal (GI) problems.

Pregnancy

Pregnancy CategoryExplanation
All TrimestersCAnimal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Using meloxicam with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Ketorolac

Using meloxicam with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Ardeparin
  • Certoparin
  • Dalteparin
  • Danaparoid
  • Enoxaparin
  • Ginkgo
  • Nadroparin
  • Parnaparin
  • Pemetrexed
  • Reviparin
  • Tacrolimus
  • Tinzaparin

Using meloxicam with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acetohexamide
  • Alacepril
  • Amiloride
  • Azosemide
  • Bemetizide
  • Benazepril
  • Bendroflumethiazide
  • Benzthiazide
  • Bumetanide
  • Buthiazide
  • Candesartan Cilexetil
  • Canrenoate
  • Captopril
  • Chlorothiazide
  • Chlorpropamide
  • Chlorthalidone
  • Cholestyramine
  • Cilazapril
  • Citalopram
  • Clopamide
  • Clopidogrel
  • Clovoxamine
  • Cyclopenthiazide
  • Cyclosporine
  • Cyclothiazide
  • Delapril
  • Desvenlafaxine
  • Duloxetine
  • Enalaprilat
  • Enalapril Maleate
  • Eprosartan
  • Escitalopram
  • Ethacrynic Acid
  • Femoxetine
  • Flesinoxan
  • Fluoxetine
  • Fluvoxamine
  • Fosinopril
  • Furosemide
  • Gliclazide
  • Glimepiride
  • Glipizide
  • Gliquidone
  • Glyburide
  • Hydrochlorothiazide
  • Hydroflumethiazide
  • Imidapril
  • Indapamide
  • Irbesartan
  • Itraconazole
  • Lisinopril
  • Lithium
  • Losartan
  • Methyclothiazide
  • Metolazone
  • Milnacipran
  • Moexipril
  • Nefazodone
  • Olmesartan Medoxomil
  • Paroxetine
  • Pentopril
  • Perindopril
  • Piretanide
  • Polythiazide
  • Quinapril
  • Quinethazone
  • Ramipril
  • Sertraline
  • Spirapril
  • Spironolactone
  • Tasosartan
  • Telmisartan
  • Temocapril
  • Tolazamide
  • Tolbutamide
  • Torsemide
  • Trandolapril
  • Triamterene
  • Trichlormethiazide
  • Valsartan
  • Venlafaxine
  • Voriconazole
  • Warfarin
  • Xipamide
  • Zimeldine
  • Zofenopril

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of meloxicam. Make sure you tell your doctor if you have any other medical problems, especially:

  • Alcohol abuse or
  • Bleeding problems or
  • Stomach ulcer or other stomach problems or
  • Tobacco (or recent history of )—The chance of side effects may be increased.
  • Anemia or
  • Asthma or
  • Bleeding problems or
  • Congestive heart failure or
  • Dehydration or
  • Edema (fluid retention or body swelling) or
  • Heart attack, history of or
  • Hypertension (high blood pressure) or
  • Kidney disease or
  • Liver disease or
  • Stomach ulcers or bleeding, history of or
  • Stroke, history of—Use with caution. Meloxicam may make these conditions worse.
  • Aspirin-sensitive asthma—Should not be used in patients with this condition.
  • Heart surgery (e.g., coronary artery bypass graft [CABG]) —Meloxicam should NOT be used for pain right before or after surgery in patients with this condition.

Proper Use of meloxicam

For safe and effective use of meloxicam, do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. Taking too much of meloxicam may increase the chance of side effects.

meloxicam should come with a medication guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.

Shake the oral suspension well before each use. Measure the medicine with a marked measuring spoon, oral syringe, or medicine cup.

You may take meloxicam with or without food.

Dosing

The dose of meloxicam will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of meloxicam. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage forms (suspension or tablets):
    • For juvenile rheumatoid arthritis:
      • Children above 2 years of age—Dose is based on body weight and must be determined by your doctor. The dose is 0.125 milligram (mg) per kilogram (kg) of body weight once a day. Your doctor may increase the dose as needed. However, the dose is usually not more than 7.5 mg once a day.
      • Children below 2 years of age—Use and dose must be determined by your doctor.
    • For osteoarthritis or rheumatoid arthritis:
      • Adults—At first, 7.5 milligrams (mg) once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 15 mg once a day.
      • Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of meloxicam, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using meloxicam

It is very important that your doctor check your progress at regular visits to make sure that meloxicam is working properly. Blood tests may be needed to check for unwanted effects.

meloxicam may increase your risk of having a heart attack or stroke. This is more likely to occur in people who already have heart disease. People who use meloxicam for a long time might also have a higher risk.

meloxicam may cause bleeding in your stomach or intestines. This problem can happen without warning signs. This is more likely to occur if you have had a stomach ulcer in the past, if you smoke or drink alcohol regularly, are over 60 years of age, are in poor health, or are using certain other medicines (such as steroids or a blood thinner).

Liver problems may occur while you are using meloxicam. Stop using meloxicam and check with your doctor right away if you are having more than one of these symptoms: abdominal pain or tenderness; clay-colored stools; dark urine; decreased appetite; fever; headache; itching; loss of appetite; nausea and vomiting; skin rash; swelling of the feet or lower legs; unusual tiredness or weakness; or yellow eyes or skin.

Stomach problems may be more likely to occur if you drink alcoholic beverages while being treated with meloxicam. Therefore, do not regularly drink alcoholic beverages while taking meloxicam, unless otherwise directed by your doctor.

Taking two or more of the nonsteroidal anti-inflammatory drugs (NSAIDs) together on a regular basis may increase the chance of unwanted effects. Also, taking acetaminophen, aspirin or other salicylates, or ketorolac (e.g., Toradol) regularly while you are taking a nonsteroidal anti-inflammatory drug may increase the chance of unwanted effects. The risk will depend on how much of each medicine you take every day, and on how long you take the medicines together. If your doctor directs you to take these medicines together on a regular basis, follow his or her directions carefully. However, do not take acetaminophen or aspirin or other salicylates together with meloxicam for more than a few days, and do not take any ketorolac (e.g., Toradol) while taking meloxicam, unless your doctor has directed you to do so and is following your progress.

Serious side effects can occur during treatment with meloxicam. Sometimes serious side effects can occur without warning. However, possible warning signs often occur, including severe stomach pain, black tarry stools, and/or vomiting of blood or material that looks like coffee grounds; skin rash; swelling of face, fingers, feet and/or lower legs. Also, signs of serious heart problems could occur such as chest pain, tightness in chest, fast or irregular heartbeat, or unusual flushing or warmth of skin. Stop taking meloxicam and check with your doctor immediately if you notice any of these warning signs.

Meloxicam may cause a serious type of allergic reaction called anaphylaxis. Although this is rare, it may occur often in patients who are allergic to aspirin or other nonsteroidal anti-inflammatory drugs. Anaphylaxis can be life-threatening and requires immediate medical attention. The most serious signs of this reaction are very fast or irregular breathing, gasping for breath, wheezing, or fainting. Other signs may include changes in skin color of face; very fast but irregular heartbeat or pulse; hive-like swellings on the skin; puffiness or swelling of the eyelids or around the eyes. If these effects occur, get emergency help at once. Ask someone to drive you to the nearest hospital emergency room. Call an ambulance, lie down, cover yourself to keep warm, and prop your feet higher than your head. Stay in that position until help arrives.

Serious skin reactions can occur with meloxicam. Check with your doctor right away if you have blistering, peeling, or loosening of the skin; red skin lesions; severe acne or skin rash; sores or ulcers on the skin; or fever or chills while you are using meloxicam.

Using meloxicam while you are pregnant can harm your unborn baby. If you think you have become pregnant while using the medicine, tell your doctor right away.

Tell your doctor if you have unexplained weight gain or edema (fluid retention or body swelling) with meloxicam.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

meloxicam Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common
  • Arm, back, or jaw pain
  • bleeding gums
  • bloating
  • blood in the urine
  • blurred vision
  • burning upper abdominal or stomach pain
  • canker sores
  • chest tightness or heaviness
  • chills
  • cloudy urine
  • cough
  • cramping
  • dark urine
  • decreased frequency or amount of urine
  • difficult or labored breathing
  • dilated neck veins
  • dizziness
  • dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
  • general tiredness and weakness
  • headache
  • hives or welts
  • increased blood pressure
  • increased sensitivity of the skin to sunlight
  • increased thirst
  • irregular breathing
  • itching, redness or other discoloration of the skin
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • light-colored stools
  • loss of appetite
  • lower side or back pain
  • noisy breathing
  • pain or discomfort in the arms, jaw, back, or neck
  • painful or difficult urination
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • pinpoint red or purple spots on the skin
  • pounding in the ears
  • redness, soreness, or itching skin
  • seizures
  • severe and continuing nausea
  • severe sunburn
  • shakiness in the legs, arms, hands, feet
  • skin blisters
  • sore throat
  • sores, ulcers, or white spots on the lips or tongue or inside the mouth
  • sores, welting, or blisters
  • stomach bloating, burning, cramping, tenderness, or pain
  • sweating
  • swelling or puffiness of the face
  • swollen glands
  • trembling or shaking of the hands or feet
  • trouble with breathing
  • unusual bleeding or bruising
  • upper right abdominal or stomach pain
  • watery or bloody diarrhea
  • weight gain or loss
  • yellow eyes or skin
Rare
  • Area rash
  • blistering, peeling, or loosening of the skin
  • bloody or black, tarry stools
  • clay-colored stools
  • cold, clammy skin
  • continuing vomiting
  • cough or hoarseness
  • cracks in the skin
  • difficulty with swallowing
  • fast, weak pulse
  • fever with or without chills
  • greatly decreased frequency of urination or amount of urine
  • joint or muscle pain
  • lightheadedness
  • loss of heat from the body
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • red irritated eyes
  • red skin lesions, often with a purple center
  • red, swollen skin
  • scaly skin
  • severe stomach pain
  • shortness of breath
  • tightness in the chest
  • unpleasant breath odor
  • unusual tiredness or weakness
  • vomiting of blood or material that looks like coffee grounds
  • wheezing
Incidence not known
  • Difficulty in speaking
  • double vision
  • inability to move the arms, legs, or facial muscles
  • inability to speak
  • pains in the chest, groin or legs, especially calves
  • severe headaches of sudden onset
  • slow speech
  • sudden loss of coordination
  • sudden onset of shortness of breath for no apparent reason
  • sudden onset of slurred speech
  • sudden vision changes

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose
  • Blue lips, fingernails, or skin
  • convulsions (seizures)
  • pain in the chest, upper stomach, or throat
  • severe stomach pain
  • skin rash
  • slow or fast heartbeat
  • swelling around the eyes, face, lips, or tongue
  • weight gain (rapid)

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Diarrhea
  • gas
  • heartburn
  • indigestion
Less common or rare
  • Abdominal or stomach pain
  • abnormal dreaming
  • anxiety
  • appetite increased
  • bad, unusual, or unpleasant aftertaste
  • belching
  • bloated full feeling
  • burning feeling in the chest or stomach
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • burning, dry, or itching eyes
  • change in taste
  • changes in vision
  • confusion
  • constipation
  • continuing ringing or buzzing or other unexplained noise in the ears
  • decreased urination
  • discharge
  • discouragement
  • dry mouth
  • excess air or gas in the stomach
  • excessive tearing
  • feeling sad or empty
  • feeling of constant movement of self or surroundings
  • general feeling of discomfort or illness
  • hair loss
  • hearing loss
  • hot flushes
  • irritability
  • loss of interest or pleasure
  • nausea or vomiting
  • nervousness
  • pain or burning in the throat
  • rapid breathing
  • redness, pain, swelling of the eye, eyelid, or inner lining of the eyelid
  • sensation of spinning
  • sleepiness
  • stomach upset
  • sunken eyes
  • tenderness in the stomach area
  • thinning of the hair
  • thirst
  • tiredness
  • trouble concentrating
  • trouble sleeping
  • wrinkled skin

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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  • Meloxicam Prescribing Information (FDA)
  • Meloxicam Professional Patient Advice (Wolters Kluwer)
  • Meloxicam Detailed Consumer Information (PDR)
  • Meloxicam MedFacts Consumer Leaflet (Wolters Kluwer)
  • Mobic Prescribing Information (FDA)
  • Mobic Consumer Overview

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