Trade Names:Mobic- Tablets 7.5 mg- Tablets 15 mg- Oral suspension 7.5 mg per 5 mLApo-Meloxicam (Canada)CO Meloxicam (Canada)Gen-Meloxicam (Canada)Mobicox (Canada)Novo-Meloxicam (Canada)PMS-Meloxicam (Canada)ratio-Meloxicam (Canada)
Decreases inflammation, pain, and fever, probably through inhibition of cyclooxygenase activity and prostaglandin synthesis.
Bioavailability is 89%. T max is 4 to 5 h. Steady state reached by day 5 with multiple dosing.
Vd is approximately 10 L; protein binding is approximately 99.4% (primarily albumin).
Meloxicam is almost completely metabolized to 4 inactive metabolites by peroxidase and CYP-450 2C9 and 3A4.
Meloxicam is equally excreted in the urine and feces, mainly in the form of metabolites. Mean t ½ is 15 to 20 h; Cl is 7 to 9 mL/min.
Meloxicam plasma concentration is decreased and Cl increased in patients with renal function impairment.
Relief of signs and symptoms of osteoarthritis and rheumatoid arthritis. Relief of the signs and symptoms of pauciarticular or polyarticular course juvenile rheumatoid arthritis (JRA) in patients 2 yr of age and older.
Treatment of ankylosing spondylitis, pain, and acute shoulder pain.
Patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs; hypersensitivity to any component of product; treatment of perioperative pain in the setting of coronary artery bypass graft (CABG) surgery.
PO 7.5 to 15 mg once daily (max, 15 mg/day).Pauciarticular and Polyarticular Course JRAChildren 2 yr of age and older
PO 0.125 mg/kg once daily (max, 7.5 mg/day).
Store at controlled room temperature (59° to 86°F). Protect tablets from moisture. Keep suspension tightly closed.
Antihypertensive effects may be decreased.Aspirin
Additive GI toxicity.Cholestyramine
Plasma levels of meloxicam may be reduced.Lithium
May increase lithium levels.Loop diuretics (eg, furosemide), thiazide diuretics (eg, chlorothiazide)
Diuretic effects may be decreased.Methotrexate
Risk of methotrexate toxicity may be increased.Warfarin
May increase risk of gastric erosion and bleeding.
None well documented.
Angina pectoris, arrhythmia, cardiac failure, hypertension, hypotension, MI, palpitation, tachycardia, vasculitis (less than 2%).
Headache (8%); dizziness, insomnia (4%); abnormal dreaming, anxiety, confusion, convulsions, depression, fatigue, increased appetite, nervousness, paresthesia, somnolence, tremor, vertigo, (less than 2%).
Rash (3%); pruritus (2%); alopecia, angioedema, bullous eruption, increased sweating, photosensitivity reaction, urticaria (less than 2%); erythema multiforme, exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis (postmarketing).
Pharyngitis (3%); abnormal vision, conjunctivitis, taste perversion, tinnitus (less than 2%).
Dyspepsia (10%); diarrhea (8%); nausea (7%); dyspeptic signs and symptoms (6%); abdominal pain (5%); constipation, flatulence, vomiting (3%); colitis, dry mouth, duodenal ulcer, eructation, esophagitis, gastric ulcer, gastritis, gastroesophageal reflux, GI hemorrhage, hematemesis, hemorrhagic duodenal ulcer, hemorrhagic gastric ulcer, intestinal perforation, melena, pancreatitis, perforated duodenal ulcer, perforated gastric ulcer, ulcerative stomatitis (less than 2%).
UTI (7%); micturition frequency (2%); albuminuria, increased BUN and creatinine, hematuria, renal failure (less than 2%); interstitial nephritis (postmarketing).
Anemia (4%); leukopenia, purpura, thrombocytopenia (less than 2%); agranulocytosis (postmarketing).
Increased ALT and AST, bilirubinemia, hepatitis, increased gamma-glutamyl-transferase (less than 2%); jaundice, liver failure (postmarketing).
Dehydration, weight decrease or increase (less than 2%).
Arthralgia (5%); back pain (3%); joint-related signs and symptoms (2%).
Upper respiratory tract infection (8%); coughing (2%); asthma, bronchospasm, dyspnea (less than 2%).
Influenza-like symptoms (6%); edema, household accidents, pain (5%); fall (3%); allergic reaction, face edema, fever, hot flushes, malaise, syncope (less than 2%); anaphylactic reactions, including shock (postmarketing).
NSAIDs may cause an increased risk of serious CV thrombotic events, MI, and stroke that can be fatal. Risk may be increased with duration of use and in patients with CV disease, or risk factors for CV disease. Use lowest effective dose for shortest duration possible. Meloxicam is contraindicated for treatment of perioperative pain in the setting of CABG surgery.GI risk
NSAIDs cause an increased risk of serious GI adverse reactions, including bleeding, ulceration, and perforation of the stomach or intestines that can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients are at greater risk for serious GI events.
Monitor for signs and symptoms of bleeding. Monitor BP closely during initiation of treatment and throughout course of therapy. Patients on long-term use should have their CBC and chemistry profile checked periodically. Evaluate renal and hepatic function prior to starting, and periodically thereafter, during long-term treatment.
Category C . Avoid use during pregnancy, particularly in late pregnancy, because of known effects of NSAIDs on the fetal CV system (eg, closure of ductus arteriosus).
Safety and efficacy not established for JRA patients younger than 2 yr of age.
Use with caution in patients 65 yr of age and older.
Not recommended in patients with advanced renal disease. Use with caution in patients with preexisting kidney disease.
Use with caution; discontinue use if clinical signs and/or symptoms of liver disease develop.
May occur. Do not give to patients with the aspirin triad.
Meloxicam is not a substitute for corticosteroids and cannot be used to treat corticosteroid insufficiency.
Use with caution. Rehydrate patient before starting therapy.
Discontinue use if clinical signs and symptoms consistent with liver or renal disease develop, systemic manifestations occur (eg, eosinophilia, rash), or if abnormal liver tests persist or worsen.
May cause fluid retention and edema; use with caution in patients with fluid retention, hypertension, or heart failure.
Use with extreme caution, or use alternative therapies not involving NSAIDs, in patients with prior history of ulcer disease or GI bleeding, or with concurrent risk factors for GI bleeding (eg, concomitant use of oral corticosteroid or anticoagulants, smoking, alcohol use, elderly or debilitated patient).
May cause anemia. May inhibit platelet aggregation and prolong bleeding time. Carefully monitor patients who may be adversely affected by alterations in platelet function (eg, coagulation disorders, concurrent anticoagulation therapy).
May lead to onset of new hypertension or worsening of preexisting hypertension. Use with caution in patients with hypertension.
Patients with asthma may have aspirin-sensitive asthma, which has been associated with severe, sometimes fatal, bronchospasm. Use with caution in patients with asthma; do not administer to patients with aspirin-sensitive asthma.
Long-term use of NSAIDs has resulted in renal papillary necrosis and other renal injury. Overt renal decompensation has occurred in patients in whom renal prostaglandins have a compensatory role in maintenance of renal perfusion.
May cause serious adverse skin reactions, including exfoliative dermatitis, Stevens-Johnson syndrome, and toxic epidermal necrolysis that can be fatal.
Acute renal failure, cardiac arrest, coma, convulsions, CV collapse, drowsiness, epigastric pain, GI bleeding, hepatic function impairment, hypertension, lethargy, nausea, respiratory depression, vomiting.
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