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Drugs reference index «Amitriptyline/Perphenazine»


Generic Name: Amitriptyline/Perphenazine (am-ee-TRIP-tih-leen/per-FEN-uh-zeen)Brand Name: Duo-Vil 2-10

Antidepressants may increase the risk of suicidal thoughts or actions in children, teenagers, and young adults. However, depression and certain other mental problems may also increase the risk of suicide. Talk with the patient's doctor to be sure that the benefits of using Amitriptyline/Perphenazine outweigh the risks.

Family and caregivers must closely watch patients who take Amitriptyline/Perphenazine . It is important to keep in close contact with the patient's doctor. Tell the doctor right away if the patient has symptoms like worsened depression, suicidal thoughts, or changes in behavior. Discuss any questions with the patient's doctor.

Amitriptyline/Perphenazine is used for:

Treating anxiety and depression.

Amitriptyline/Perphenazine is a phenothiazine and tricyclic antidepressant combination. It works by altering the levels of naturally occurring chemicals in the brain.

Do NOT use Amitriptyline/Perphenazine if:

  • you are allergic to any ingredient in Amitriptyline/Perphenazine
  • you have certain types of brain damage
  • you have blood disorders, liver damage, decreased bone marrow function, or a recent heart attack
  • you are taking astemizole, cisapride, terfenadine, or tramadol
  • you have taken furazolidone or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.

Before using Amitriptyline/Perphenazine :

Some medical conditions may interact with Amitriptyline/Perphenazine . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of breast cancer, seizures, asthma, lung problems (eg, emphysema), trouble urinating, alcohol abuse, depression, or suicidal thoughts or attempts
  • if you have a lung infection, heart or blood disease, Reye syndrome, Parkinson disease, glaucoma, high or low blood pressure, prostate problems, or an overactive thyroid
  • if you are undergoing electroshock therapy (ECT)

Some MEDICINES MAY INTERACT with Amitriptyline/Perphenazine . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Anticholinergics (eg, benztropine), antihistamines (eg, diphenhydramine), barbiturates (eg, phenobarbital), carbamazepine, cimetidine, disulfiram, fluconazole, mibefradil, opiates (eg, codeine), phenothiazines, quinidine, terbinafine, or valproic acid because they may increase the risk of Amitriptyline/Perphenazine 's side effects
  • Arsenic, astemizole, butyrophenones, cisapride, droperidol, furazolidone, haloperidol, macrolide antibiotics (eg, erythromycin), MAOIs (eg, phenelzine), pimozide, selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine), serotonin and norepinephrine reuptake inhibitors (eg, venlafaxine), streptogramins, terfenadine, or tramadol because the risk of severe heart, nervous system, or muscle problems or seizures may be increased
  • Benzodiazepines because they may decrease Amitriptyline/Perphenazine 's effectiveness
  • Anticoagulants (eg, warfarin), hydantoins, or sympathomimetics (eg, pseudoephedrine) because the risk of their side effects may be increased by Amitriptyline/Perphenazine
  • Clonidine, guanethidine, guanfacine, levodopa, or pergolide because their effectiveness may be decreased by Amitriptyline/Perphenazine

This may not be a complete list of all interactions that may occur. Ask your health care provider if Amitriptyline/Perphenazine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Amitriptyline/Perphenazine :

Use Amitriptyline/Perphenazine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Amitriptyline/Perphenazine comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Amitriptyline/Perphenazine refilled.
  • Take Amitriptyline/Perphenazine by mouth with or without food.
  • If you miss a dose of Amitriptyline/Perphenazine , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Amitriptyline/Perphenazine .

Important safety information:

  • Amitriptyline/Perphenazine may cause drowsiness, dizziness, or fainting. These effects may be worse if you take it with alcohol or certain medicines. Use Amitriptyline/Perphenazine with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Amitriptyline/Perphenazine ; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
  • Amitriptyline/Perphenazine may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
  • Amitriptyline/Perphenazine may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Amitriptyline/Perphenazine . Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
  • Do not become overheated in hot weather or while you are being active; heatstroke may occur.
  • Children, teenagers, and young adults who take Amitriptyline/Perphenazine may be at increased risk for suicidal thoughts or actions. Watch all patients who take Amitriptyline/Perphenazine closely. Contact the doctor at once if new, worsened, or sudden symptoms such as depressed mood; anxious, restless, or irritable behavior; panic attacks; or any unusual change in mood or behavior occur. Contact the doctor right away if any signs of suicidal thoughts or actions occur.
  • Neuroleptic malignant syndrome (NMS) is a possibly fatal syndrome that can be caused by Amitriptyline/Perphenazine . Symptoms may include fever; stiff muscles; confusion; abnormal thinking; fast or irregular heartbeat; and sweating. Contact your doctor at once if you have any of these symptoms.
  • Some patients who take Amitriptyline/Perphenazine may develop muscle movements that they cannot control. This is more likely to happen in elderly patients, especially women. The chance that this will happen or that it will become permanent is greater in those who take Amitriptyline/Perphenazine in higher doses or for a long time. Muscle problems may also occur after short-term treatment with low doses. Tell your doctor at once if you have muscle problems with your arms; legs; or your tongue, face, mouth, or jaw (eg, tongue sticking out, puffing of cheeks, mouth puckering, chewing movements) while taking Amitriptyline/Perphenazine .
  • Tell your doctor or dentist that you take Amitriptyline/Perphenazine before you receive any medical or dental care, emergency care, or surgery.
  • Lab tests, including liver and kidney function and complete blood cell counts, may be performed while you use Amitriptyline/Perphenazine . These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Amitriptyline/Perphenazine with caution in the ELDERLY; they may be more sensitive to its effects.
  • Amitriptyline/Perphenazine should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: It is not known if Amitriptyline/Perphenazine can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Amitriptyline/Perphenazine while you are pregnant. Amitriptyline/Perphenazine is found in breast milk. Do not breast-feed while taking Amitriptyline/Perphenazine .

If you stop taking Amitriptyline/Perphenazine suddenly, you may have WITHDRAWAL symptoms. These may include dizziness, nausea, upset stomach, and vomiting.

Possible side effects of Amitriptyline/Perphenazine :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Blurred vision; changes in color of cornea and lens; changes in menstrual cycle; constipation; diarrhea; dizziness; drowsiness; dry mouth; flushing; headache; lack of energy; loss of appetite; nausea; sleeplessness; stuffy nose; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); agitation; altered mental abilities, including lack of response to your surroundings; breast growth; changes in vision or other vision problems; chest pain; confusion; difficulty sleeping; difficulty speaking or swallowing; difficulty urinating; drooling from the mouth; excessive drowsiness; excessive hunger, thirst, or urination; fainting; feeling of irritability or hostility; fever; impulsive behavior or other unusual changes in behavior; inability to urinate; involuntary movements of tongue, face, mouth, or jaw, sometimes with involuntary movements of the arms and legs; loss of bladder control; mental or mood changes; muscle rigidness or stiffness; nightmares; panic attacks; rapid or irregular heartbeat; restlessness; ringing in the ears; severe nervousness or anxiety; severe restlessness; severe stomach pain; sore throat; suicidal thoughts; sweating; swelling of the legs and feet; tremors; uncoordinated movements; weakness in the arms or legs; worsening feelings of depression; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include confusion; dilated pupils; drowsiness; fever; hallucinations; lightheadedness; muscle rigidity; rapid pulse; seizures; uncontrollable movements of the tongue, mouth, or face; vomiting.

Proper storage of Amitriptyline/Perphenazine :

Store Amitriptyline/Perphenazine at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Amitriptyline/Perphenazine out of the reach of children and away from pets.

General information:

  • If you have any questions about Amitriptyline/Perphenazine , please talk with your doctor, pharmacist, or other health care provider.
  • Amitriptyline/Perphenazine is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Amitriptyline/Perphenazine . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

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