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Drugs reference index «Amlodipine Besylate/Benazepril Hydrochloride»

Amlodipine Besylate / Benazepril Hydrochloride

Pronunciation: (am-LOW-dih-PEEN BEH-sih-LATE/BEN-AZE-uh-pril HIGH-droe-CLOR-ide)Class: Antihypertensive combination

Trade Names:Lotrel- Capsule amlodipine 2.5 mg/benazepril 10 mg- Capsule amlodipine 5 mg/benazepril 10 mg- Capsule amlodipine 5 mg/benazepril 20 mg- Capsule amlodipine 5 mg/benazepril 40 mg- Capsule amlodipine 10 mg/benazepril 20 mg- Capsule amlodipine 10 mg/benazepril 40 mg


Amlodipine: Inhibits movement of calcium ions across cell membrane in systemic and coronary vascular smooth muscle; benazepril: competitively inhibits angiotensin I-converting enzyme, resulting in the prevention of angiotensin I conversion to angiotensin II, a potent vasoconstrictor that stimulates aldosterone secretion. This action results in a decrease in sodium and fluid retention, increase in diuresis, and a decrease in blood pressure.

Indications and Usage

Treatment of hypertension.


Hypersensitivity to amlodipine, benazepril, or any other ACE inhibitor.

Dosage and Administration


PO 1 capsule (amlodipine 2.5 to 10 mg/benazepril 10 to 40 mg)/day.


PO Initially amlodipine 2.5 mg/day

Renal Function Impairment

CrCl less than 30 mL/min - amlodipine/benazepril not recommended.

Hepatic Function Impairment

PO Initially amlodipine 2.5 mg/day.


Store capsules at controlled room temperature (59° to 86°F). Protect from moisture and light.

Drug Interactions


Increased risk of excessive reduction of blood pressure after initiation of amlodipine/benazepril therapy.

Potassium supplements, potassium-sparing diuretics (eg, spironolactone)

Increased risk of hyperkalemia.


Plasma levels of lithium may be elevated, increasing the risk of toxicity.

Laboratory Test Interactions

None well documented.

Adverse Reactions




Headache; dizziness; somnolence; fatigue; insomnia; nervousness; anxiety; tremor; decreased libido.


Rash; skin nodule; dermatitis; Stevens-Johnson syndrome.




Dry mouth; nausea; abdominal pain; constipation; diarrhea; dyspepsia.


Impotence; polyuria.


Hemolytic anemia; thrombocytopenia.


Jaundice; hepatic enzyme elevations consistent with cholestasis.




Cough; pharyngitis.


Edema; flushing; hot flashes; angioedema; asthenia; back pain; musculoskeletal pain; cramps; muscle cramps.



When used in pregnancy during the second and third trimesters, ACE inhibitors can cause injury and even death to the developing fetus. When pregnancy is detected, discontinue therapy as soon as possible.


Category D (second and third trimester); Category C (first trimester). ACE inhibitors (eg, benazepril) can cause injury or death to fetus if used during second or third trimester. When pregnancy is detected, discontinue as soon as possible.


Amlodipine: Undetermined; benazepril: excreted in breast milk.


Safety and efficacy not established.

Renal Function

Use with caution.


Has been reported and may be fatal.


Has been reported, especially in patients who are volume or salt depleted (eg, those undergoing dialysis, dietary salt restriction, or prolonged diuretic therapy, or who are experiencing diarrhea or vomiting); use with caution.


Has occurred with ACE inhibitors.

Patient Information

  • Advise patient to take once daily as prescribed, without regard to meals.
  • Advise patient to try to take each dose at about the same time each day.
  • Inform patient that drug controls, but does not cure, hypertension and to continue taking drug as prescribed even when BP is not elevated.
  • Caution patient not to change the dose or stop taking unless advised by health care provider.
  • Instruct patient to continue taking other BP medications as prescribed by health care provider.
  • Instruct patient in BP and pulse measurement skills.
  • Advise patient to monitor and record BP and pulse at home and to inform health care provider should abnormal measurements be noted. Also advise patient to take record of BP and pulse to each follow-up visit.
  • Instruct patient to lie or sit down if experiencing dizziness or lightheadedness when standing.
  • Caution patient that inadequate fluid intake, excessive perspiration, diarrhea, or vomiting can lead to excessive fall in BP resulting in lightheadedness or fainting.
  • Emphasize to hypertensive patient importance of other modalities on BP: weight control, regular exercise, smoking cessation, and moderate intake of alcohol and salt.
  • Caution patient to not take any salt substitutes unless advised by health care provider.
  • Instruct patient to stop taking drug and immediately report any of these symptoms to health care provider: fainting, swelling of the face, lips, eyelids, or tongue.
  • Instruct patient to inform health care provider if a persistent cough or swelling of the ankles or feet develop while taking this medication.

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