Trade Names:Lotrel- Capsule amlodipine 2.5 mg/benazepril 10 mg- Capsule amlodipine 5 mg/benazepril 10 mg- Capsule amlodipine 5 mg/benazepril 20 mg- Capsule amlodipine 5 mg/benazepril 40 mg- Capsule amlodipine 10 mg/benazepril 20 mg- Capsule amlodipine 10 mg/benazepril 40 mg
Amlodipine: Inhibits movement of calcium ions across cell membrane in systemic and coronary vascular smooth muscle; benazepril: competitively inhibits angiotensin I-converting enzyme, resulting in the prevention of angiotensin I conversion to angiotensin II, a potent vasoconstrictor that stimulates aldosterone secretion. This action results in a decrease in sodium and fluid retention, increase in diuresis, and a decrease in blood pressure.
Treatment of hypertension.
Hypersensitivity to amlodipine, benazepril, or any other ACE inhibitor.
PO 1 capsule (amlodipine 2.5 to 10 mg/benazepril 10 to 40 mg)/day.Elderly
PO Initially amlodipine 2.5 mg/dayRenal Function Impairment
CrCl less than 30 mL/min - amlodipine/benazepril not recommended.Hepatic Function Impairment
PO Initially amlodipine 2.5 mg/day.
Store capsules at controlled room temperature (59° to 86°F). Protect from moisture and light.
Increased risk of excessive reduction of blood pressure after initiation of amlodipine/benazepril therapy.Potassium supplements, potassium-sparing diuretics (eg, spironolactone)
Increased risk of hyperkalemia.Lithium
Plasma levels of lithium may be elevated, increasing the risk of toxicity.
None well documented.
Headache; dizziness; somnolence; fatigue; insomnia; nervousness; anxiety; tremor; decreased libido.
Rash; skin nodule; dermatitis; Stevens-Johnson syndrome.
Dry mouth; nausea; abdominal pain; constipation; diarrhea; dyspepsia.
Hemolytic anemia; thrombocytopenia.
Jaundice; hepatic enzyme elevations consistent with cholestasis.
Edema; flushing; hot flashes; angioedema; asthenia; back pain; musculoskeletal pain; cramps; muscle cramps.
When used in pregnancy during the second and third trimesters, ACE inhibitors can cause injury and even death to the developing fetus. When pregnancy is detected, discontinue therapy as soon as possible.
Category D (second and third trimester); Category C (first trimester). ACE inhibitors (eg, benazepril) can cause injury or death to fetus if used during second or third trimester. When pregnancy is detected, discontinue as soon as possible.
Amlodipine: Undetermined; benazepril: excreted in breast milk.
Safety and efficacy not established.
Use with caution.
Has been reported and may be fatal.
Has been reported, especially in patients who are volume or salt depleted (eg, those undergoing dialysis, dietary salt restriction, or prolonged diuretic therapy, or who are experiencing diarrhea or vomiting); use with caution.
Has occurred with ACE inhibitors.
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