Generic Name: hyaluronidase (injectable) (HYE al ure ON i dase)Brand Names: Amphadase, Hydase, Hylenex, Vitrase
Hyaluronidase is a genetically designed protein.
Hyaluronidase is used as an aid in helping your body absorb other injected medications.
Hyaluronidase is also used to help contrast dyes in your body show more clearly on certain types of x-rays or scans.
Hyaluronidase may also be used for other purposes not listed in this medication guide.
Your doctor may perform a skin test to see if you are allergic to hyaluronidase before you receive the medication.
Before receiving hyaluronidase, tell your doctor if you are using any of the following drugs: furosemide (Lasix); phenytoin (Dilantin); a sedative or anxiety medication (such as Valium, Xanax, Tranxene); aspirin or salicylates; cortisone or ACTH (Corticotropin); estrogens; or an antihistamine (such as a cold or allergy medicine).
What should I discuss with my health care provider before receiving hyaluronidase?Your doctor may perform a skin test to see if you are allergic to hyaluronidase before you receive the medication.
FDA pregnancy category C. It is not known whether this medication is harmful to an unborn baby. Before you receive hyaluronidase, tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known if hyaluronidase passes into breast milk or if it could harm a nursing baby. Do not receive this medication without telling your doctor if you are breast-feeding a baby.This medication is given as an injection under the skin. You will receive the injection from a doctor or other healthcare professional.
Call your doctor for instructions if you miss an appointment for your hyaluronidase injection.
Symptoms of a hyaluronidase overdose may include itching or swelling where the injection was given. Other possible symptoms include chills, dizziness, nausea, vomiting, fast heartbeat, or fainting.
Follow your doctor's instructions about any restrictions on food, beverages, or activity while you are using hyaluronidase.
Less serious side effects may include:
pain or tenderness where the medication was injected; or
swelling in any part of your body.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before receiving hyaluronidase, tell your doctor if you are using any of the following drugs:
furosemide (Lasix);
phenytoin (Dilantin);
a sedative or anxiety medication (such as Valium, Xanax, Tranxene);
aspirin or salicylates;
cortisone or ACTH (Corticotropin);
estrogens; or
an antihistamine (such as a cold or allergy medicine).
This list is not complete and there may be other drugs that can interact with hyaluronidase. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.