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Drugs reference index «Neupogen»

Neupogen
Neupogen
Neupogen


Neupogen

Generic Name: filgrastim (Injection route)

fil-GRA-stim

Commonly used brand name(s):

In the U.S.

  • Neupogen

Available Dosage Forms:

  • Solution
  • Injectable

Therapeutic Class: Hematopoietic

Pharmacologic Class: Colony Stimulating Factor

Uses For Neupogen

Filgrastim is a synthetic (man-made) version of a substance that is naturally produced in your body called a colony stimulating factor. It helps the bone marrow to make new white blood cells .

When certain cancer medicines are used to fight cancer cells, they also affect the white blood cells that fight infections. Filgrastim is used to prevent or reduce the risk of infection while you are being treated with cancer medicines. This medicine is also used to help the bone marrow recover after a bone marrow transplantation, and for a process called peripheral blood progenitor cell collection in cancer patients .

This medicine is available only with your doctor's prescription .

Before Using Neupogen

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatrics-specific problems that would limit the usefulness of filgrastim in children. However, safety and efficacy have not been established in babies younger than 1 month of age .

Geriatric

Appropriate studies performed to date have not demonstrated geriatrics-specific problems that would limit the usefulness of filgrastim in the elderly .

Pregnancy

Pregnancy CategoryExplanation
All TrimestersCAnimal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Topotecan
  • Vincristine
  • Vincristine Liposome

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Sickle cell disease (red blood cell disease)—May make this condition worse .

Proper Use of Neupogen

A nurse or other trained health professional may give you this medicine. This medicine is given as a shot under your skin, or into a vein .

You may be taught how to give this medicine at home. Make sure you understand all of the instructions before giving yourself an injection. Do not use more medicine or use it more often than your doctor tells you to .

This medicine comes with patient instructions. Read and follow these instructions carefully. Ask your doctor if you have any questions about:

  • How to prepare the injection.
  • The proper use of disposable syringes.
  • How to give the injection.
  • How long the injection can be stored at home .

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For injectable dosage form:
    • To increase white blood cells:
      • Adults and children—Dose is based on weight and must be determined by your doctor.
      • Newborn babies—Use and dose must be determined by your doctor .

Missed Dose

This medicine needs to be given on a fixed schedule. If you miss a dose or forget to use your medicine, call your doctor or pharmacist for instructions.

Storage

Store in the refrigerator. Do not freeze.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Neupogen

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood tests may be needed to check for unwanted effects .

Check with your doctor right away at the first sign of any infection such as fever, chills, cough, sore throat, or unusual tiredness or weakness .

This medicine may cause a serious allergic reaction that requires immediate medical attention. Tell your doctor right away if you have a rash; itching; swelling of the face, tongue, or throat; trouble with breathing; or chest pain after you get the injection .

Check with your doctor right away if you are having a pain in the upper left part of your abdomen or at the tip of the left shoulder. This could be a symptom of a serious side effect with the spleen .

Check with your doctor right away if you develop shortness of breath, chest pain or tightness, trouble with breathing, or wheezing. These could be symptoms of a serious lung condition called acute respiratory distress syndrome (ARDS) .

This medicine may also cause bleeding in your lungs. Check with your doctor right away if you cough up blood or if you have blood in your sputum (spit) .

Tell your doctor if you are allergic to rubber. The needle cover of the prefilled syringe contains dry natural rubber latex, which may cause an allergic reaction if you have a latex allergy .

Neupogen Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common
  • Abdominal or stomach pain
  • bleeding gums
  • bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  • blood in the urine or stools
  • bloody nose
  • cough
  • coughing up blood
  • decrease in height
  • diarrhea
  • difficult or labored breathing
  • difficulty swallowing
  • dizziness
  • facial swelling
  • feeling of fullness
  • fever or chills
  • headache
  • increased menstrual flow or vaginal bleeding
  • lower back or side pain
  • nausea or vomiting
  • nosebleeds
  • pain in the back, ribs, arms, or legs
  • pain spreading to the left shoulder
  • painful or difficult urination
  • pale skin
  • paralysis
  • pinpoint red or purple spots on the skin
  • prolonged bleeding from cuts
  • red or black, tarry stools
  • red or dark brown urine
  • shortness of breath
  • skin rash
  • sore throat
  • sores, ulcers, or white spots on the lips, tongue, or inside the mouth
  • tightness in the chest
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • wheezing
Less common
  • Blurred vision
  • chest pain
  • nervousness
  • pounding in the ears
  • slow or fast heartbeats
Incidence not known
  • Blisters on the skin
  • blue lips, fingernails, or skin
  • difficult or fast breathing
  • fever sores on the skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Bone, joint, or muscle pain
  • hair loss or thinning of hair
  • loss of appetite
  • weight loss
Less common
  • Cracked lips
  • difficulty having a bowel movement (stool)
  • swelling or inflammation of the mouth

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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  • Neupogen Prescribing Information (FDA)
  • Neupogen MedFacts Consumer Leaflet (Wolters Kluwer)
  • Neupogen Consumer Overview

See Also...

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