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Drugs reference index «nimodipine»

nimodipine (Oral route)

nye-MOE-di-peen

Oral routeCapsule, Liquid Filled

Do not administer nimodipine intravenously or by other parenteral routes. Deaths and serious, life threatening adverse events have occurred when the contents of nimodipine capsules have been injected parenterally .

Not for intravenous or parenteral administration. Deaths and serious, life threatening adverse events have occurred when the contents of nimodipine capsules have been injected parenterally .

Commonly used brand name(s):

In the U.S.

  • Nimotop

Available Dosage Forms:

  • Capsule, Liquid Filled
  • Tablet

Therapeutic Class: Cardiovascular Agent

Pharmacologic Class: Calcium Channel Blocker

Chemical Class: Dihydropyridine

Uses For nimodipine

Nimodipine is used to treat symptoms resulting from a ruptured blood vessel in the brain (subarachnoid hemorrhage). It works by increasing the blood flow to injured brain tissue .

nimodipine is available only with your doctor's prescription .

Before Using nimodipine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For nimodipine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to nimodipine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of nimodipine in the pediatric population. Safety and efficacy have not been established .

Geriatric

Appropriate studies performed to date have not demonstrated geriatrics-specific problems that would limit the usefulness of nimodipine in the elderly. However, elderly patients are more likely to have age-related kidney, liver, or heart problems, which may require caution in patients receiving nimodipine .

Pregnancy

Pregnancy CategoryExplanation
All TrimestersCAnimal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Using nimodipine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Amiodarone
  • Fentanyl

Using nimodipine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acebutolol
  • Alprenolol
  • Atenolol
  • Betaxolol
  • Bevantolol
  • Bisoprolol
  • Bucindolol
  • Carteolol
  • Carvedilol
  • Celiprolol
  • Dalfopristin
  • Dilevalol
  • Esmolol
  • Indinavir
  • Itraconazole
  • Labetalol
  • Levobunolol
  • Mepindolol
  • Metipranolol
  • Metoprolol
  • Nadolol
  • Nebivolol
  • Oxprenolol
  • Penbutolol
  • Phenobarbital
  • Pindolol
  • Propranolol
  • Quinupristin
  • Rifapentine
  • Saquinavir
  • Sotalol
  • St John's Wort
  • Talinolol
  • Tertatolol
  • Timolol
  • Valproic Acid

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Using nimodipine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use nimodipine, or give you special instructions about the use of food, alcohol, or tobacco.

  • Grapefruit Juice

Other Medical Problems

The presence of other medical problems may affect the use of nimodipine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body .

Proper Use of nimodipine

Take nimodipine exactly as directed even if you feel well and do not notice any symptoms. Do not take more of nimodipine and do not take it more often than your doctor ordered. Do not miss any doses .

nimodipine is usually given within 96 hours of having the condition. It is best to take nimodipine not less than one hour before or two hours after a meal .

If the capsule cannot be swallowed or if you are using nimodipine with a nasogastric tube (NGT), you may put a hole in both ends of the capsule and remove its contents using a syringe. Use the syringe to give the medicine orally or through the NGT. Do not use it to give the medicine as an injection through the veins, muscles, or skin .

Dosing

The dose of nimodipine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of nimodipine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (capsules):
    • For subarachnoid hemorrhage:
      • Adults—60 milligrams (mg) or two 30 mg capsules every 4 hours for 21 days.
      • Children—Use and dose must be determined by your doctor .

Missed Dose

If you miss a dose of nimodipine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using nimodipine

It is very important that your doctor check your progress at regular visits to make sure nimodipine is working properly and to check for unwanted effects .

nimodipine Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common
  • Chest pain or discomfort
  • decreased blood pressure
  • difficult or labored breathing
  • fast, pounding, or irregular heartbeat or pulse
  • lightheadedness, dizziness, or fainting
  • shortness of breath
  • slow or irregular heartbeat
  • swelling
  • tightness in chest
  • unusual tiredness
  • wheezing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Abdominal or stomach cramps, discomfort, or pain
  • back pain
  • blemishes on the skin
  • constipation
  • diarrhea
  • discouragement
  • feeling sad or empty
  • headache
  • indigestion
  • irritability
  • lack or loss of appetite
  • loss of interest or pleasure
  • muscle pain
  • nausea or vomiting
  • pimples
  • rash
  • swollen mouth and tongue
  • tiredness
  • trouble concentrating
  • trouble sleeping
  • unpleasant taste
  • urge to have bowel movement

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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  • nimodipine Concise Consumer Information (Cerner Multum)
  • Nimodipine Prescribing Information (FDA)
  • Nimodipine Professional Patient Advice (Wolters Kluwer)
  • Nimodipine MedFacts Consumer Leaflet (Wolters Kluwer)
  • Nimotop Prescribing Information (FDA)

See Also...

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