Treating hereditary tyrosinemia type 1 (HT-1), a genetic metabolism disorder. Nitisinone is used in combination with dietary restriction of tyrosine and phenylalanine.
Nitisinone is a 4-hydroxyphenylpyruvate dioxygenase inhibitor. It works by blocking the breakdown of tyrosine. This helps to reduce the amount of toxic byproducts in the body produced by the breakdown of tyrosine.
Contact your doctor or health care provider right away if any of these apply to you.
Some medical conditions may interact with Nitisinone . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
Some MEDICINES MAY INTERACT with Nitisinone . However, no specific interactions with Nitisinone are known at this time.
This may not be a complete list of all interactions that may occur. Ask your health care provider if Nitisinone may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
Use Nitisinone as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Ask your health care provider any questions you may have about how to use Nitisinone .
All medicines may cause side effects, but many people have no, or minor, side effects. When used in small doses, no COMMON side effects have been reported with this product. Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black or bloody stools; blue skin or nails; dark urine; eye problems (eg, redness, swelling, burning, vision changes, light sensitivity, pain); fever, chills, or persistent sore throat; seizures; severe headache; skin lesions; stomach pain; unusual bruising or bleeding; yellowing of the eyes or skin.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include eye problems (eg, redness, swelling, burning, vision changes, light sensitivity, pain); skin lesions.Proper storage of Nitisinone :
Store Nitisinone in the refrigerator between 36 and 46 degrees F (2 and 8 degrees C). Keep Nitisinone out of the reach of children and away from pets.
This information is a summary only. It does not contain all information about Nitisinone . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.