Generic Name: norfloxacin (nor FLOX a sin)Brand Names: Noroxin
Norfloxacin is in a group of antibiotics called fluoroquinolones (flor-o-KWIN-o-lones). Norfloxacin fights bacteria in the body.
Norfloxacin is used to treat bacterial infections of the prostate and urinary tract. Norfloxacin also treats gonorrhea.
Norfloxacin may also be used for other purposes not listed in this medication guide.
Before taking norfloxacin, tell your doctor if you have kidney or liver disease, myasthenia gravis, joint problems, seizures or epilepsy, diabetes, low levels of potassium in your blood (hypokalemia), or a personal or family history of "Long QT syndrome."Avoid taking antacids, vitamin or mineral supplements, sucralfate (Carafate), or didanosine (Videx) powder or chewable tablets within 2 hours before or after you take norfloxacin. These other medicines can make norfloxacin much less effective when taken at the same time.
Taking norfloxacin can make your skin more sensitive to sunlight. Avoid exposure to sunlight, sun lamps, or tanning beds.Norfloxacin may cause swelling or tearing of a tendon (the fiber that connects bones to muscles in the body), especially in the Achilles' tendon of the heel. These effects may be more likely to occur if you are over 60, if you take an oral steroid medication, or if you have had a kidney, heart, or lung transplant. Stop taking norfloxacin and call your doctor at once if you have sudden pain, swelling, tenderness, stiffness, or movement problems in any of your joints. Rest the joint until you receive medical care or instructions. Do not share this medication with another person (especially a child), even if they have the same symptoms you do.
Before taking norfloxacin, tell your doctor if you have a heart rhythm disorder, especially if you are being treated with one of these medications: quinidine (Cardioquin, Quinidex, Quinaglute), disopyramide (Norpace), bretylium (Bretylol), procainamide (Pronestyl, Procan SR), amiodarone (Cordarone, Pacerone), or sotalol (Betapace).
If you have any of these other conditions, you may need a dose adjustment or special tests to safely take norfloxacin:
epilepsy or a history of seizures;
low levels of potassium in your blood (hypokalemia); or
a personal or family history of "Long QT syndrome."
Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.Take norfloxacin with a full glass of water (8 ounces). Drink several extra glasses of fluid each day to prevent crystals from forming in the urine. Take norfloxacin on an empty stomach 1 hour before or 2 hours after eating a meal, drinking milk, or eating a dairy product such as yogurt or cheese.
If you are being treated for gonorrhea, your doctor may also have you tested for syphilis, another sexually transmitted disease.Take this medication for as many days as it has been prescribed for you even if you begin to feel better. Your symptoms may get better before the infection is completely treated. Norfloxacin will not treat a viral infection such as the common cold or flu. Store this medication at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.
See also: Norfloxacin dosage in more detail
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.
antacids that contain magnesium or aluminum (such as Maalox, Mylanta, or Rolaids);
the ulcer medicine sucralfate (Carafate);
didanosine (Videx) powder or chewable tablets; or
vitamin or mineral supplements that contain iron or zinc.
Avoid caffeine while you are taking norfloxacin, because the medication can make the effects of caffeine stronger.Avoid exposure to sunlight, sunlamps, or tanning beds. Norfloxacin can make your skin more sensitive to sunlight, and a sunburn may result. Wear protective clothing and use a sunscreen (SPF-15 or higher) if you must be out in the sun. Call your doctor if you have severe burning, redness, itching, rash, or swelling after being in the sun.
Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.Norfloxacin can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.
diarrhea that is watery or bloody;
confusion, hallucinations, unusual thoughts or behavior;
dizziness, fainting, fast or pounding heartbeat;
sudden pain, snapping or popping sound, bruising, loss of movement, or swelling near your joints (especially in your arm or ankle);
urinating less than usual or not at all;
numbness, burning, pain, or tingly feeling in your hands or feet;
pain in your upper stomach, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
pale skin, easy bruising or bleeding, weakness;
fever, swollen glands, general ill feeling;
sore throat, and headache with a severe blistering, peeling, and red skin rash; or
the first sign of any skin rash, no matter how mild.
Less serious side effects may include:
nausea, vomiting, mild stomach pain, constipation;
feeling restless or anxious;
sleep problems (insomnia or nightmares);
vaginal itching or discharge; or
mild skin itching.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Usual Adult Dose for Campylobacter Gastroenteritis:
400 mg orally every 12 hours for 3 daysImmunocompromised patients may require therapy for 7 to 14 days.
Usual Adult Dose for Cystitis:
Cystitis caused by E coli, K pneumoniae, or P mirabilis: 400 mg orally every 12 hours for 3 daysCystitis caused by other bacteria: 400 mg orally every 12 hours for 7 to 10 days
Usual Adult Dose for Epididymitis -- Non-Specific:
Nonsexually transmitted: 400 mg orally every 12 hours for 14 days
Usual Adult Dose for Gonococcal Infection -- Uncomplicated:
800 mg orally one timeDue to high rates of resistance, the Centers for Disease Control and Prevention (CDC) do not recommend fluoroquinolones for treatment of gonococcal infections in the United States or for infections acquired in Asia, the Pacific Islands, England, and Wales. Ceftriaxone or oral cefixime are recommended as first-line treatment of gonorrhea in the United States or acquired in these areas. Antimicrobial susceptibility patterns should be monitored. The CDC recommend fluoroquinolones as alternative therapy only when culture proves susceptibility.Doxycycline therapy for 7 days (if not pregnant) or single-dose azithromycin is also recommended for possible coexisting chlamydial infection.The patient's sexual partner(s) should also be evaluated/treated.
Usual Adult Dose for Prostatitis:
400 mg orally every 12 hours for 28 days
Usual Adult Dose for Pyelonephritis:
Mild infections: 400 mg orally every 12 hours for 14 days
Usual Adult Dose for Salmonella Enteric Fever:
400 mg orally every 12 hours for 7 to 14 days
Usual Adult Dose for Salmonella Gastroenteritis:
400 mg orally every 12 hours for 5 days; however, most cases are self-limiting and prudent withholding of antibiotic therapy does not appear to slow recoveryImmunocompromised patients may require therapy for 14 days.
Usual Adult Dose for Shigellosis:
400 mg orally every 12 hours for 5 daysImmunocompromised patients may require therapy for 7 to 10 days.
Usual Adult Dose for Traveler's Diarrhea:
400 mg orally every 12 hours for 3 days; however, most cases are self-limiting and prudent withholding of antibiotic therapy does not appear to slow recoveryImmunocompromised patients may require therapy for 7 to 14 days.
Usual Adult Dose for Urinary Tract Infection:
Uncomplicated: 400 mg orally every 12 hours for 7 to 10 daysComplicated: 400 mg orally every 12 hours for 10 to 21 days
Before taking norfloxacin, tell your doctor if you are taking any of the following drugs:
a blood thinner such as warfarin (Coumadin);
clozapine (Clozaril, FazaClo);
cyclosporine (Neoral, Sandimmune, Gengraf);
insulin or diabetes medication you take by mouth, such as glyburide (Micronase, Diabeta, Glynase);
nitrofurantoin (Macrodantin, Macrobid);
theophylline (Theo-Dur, Theolair, Slo-Phyllin, Slo-Bid, Elixophyllin);
a nonsteroidal anti-inflammatory drug (NSAID) such as ibuprofen (Motrin, Advil, Nuprin, others), etodolac (Lodine), diclofenac (Cataflam, Voltaren), indomethacin (Indocin), nabumetone (Relafen), meloxicam (Mobic), naproxen (Aleve, Naprosyn, Anaprox), piroxicam (Feldene), and others; or
an oral steroid medication such as betamethasone (Celestone), dexamethasone (Decadron, Dexpak), methylprednisolone (Medrol), prednisolone (Orapred), prednisone (Meticorten, Sterapred), and others.
This list is not complete and there may be other drugs that can interact with norfloxacin. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.