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Drugs reference index «acetaminophen and hydrocodone»

acetaminophen and hydrocodone

Generic Name: acetaminophen and hydrocodone (a SEET a MIN oh fen and hye droe KOE done)Brand names: Anexsia, Dolorex Forte, Hycet, Liquicet, Lorcet 10/650, Lorcet Plus, Lortab 10/500, Lortab 2.5/500, Lortab 5/500, Lortab 7.5/500, Lortab Elixir, Maxidone, Norco, Polygesic, Stagesic, Vicodin, Vicodin ES, Vicodin HP, Xodol, Xodol 5, Zamicet, Zydone, ...show all 33 brand names.Lortab, Lorcet HD, Bancap HC, Hy-Phen, Co-Gesic, Anolor DH5, Panacet, T-Gesic, Vanacet, Dolacet, Stagesic-10

What is acetaminophen and hydrocodone?

Hydrocodone is in a group of drugs called narcotic pain relievers.

Acetaminophen is a less potent pain reliever that increases the effects of hydrocodone.

The combination of acetaminophen and hydrocodone is used to relieve moderate to severe pain.

Acetaminophen and hydrocodone may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about acetaminophen and hydrocodone?

Tell your doctor if you drink more than three alcoholic beverages per day or if you have ever had alcoholic liver disease (cirrhosis). You may not be able to take medication that contains acetaminophen.

Hydrocodone may be habit-forming and should be used only by the person it was prescribed for. Keep the medication in a secure place where others cannot get to it. This medication can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Tell your doctor if the medicine seems to stop working as well in relieving your pain.

What should I discuss with my healthcare provider before taking acetaminophen and hydrocodone?Do not use this medication if you are allergic to acetaminophen (Tylenol) or hydrocodone. Hydrocodone may be habit-forming and should be used only by the person it was prescribed for. Acetaminophen and hydrocodone should never be given to another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it.

If you have any of these other conditions, you may need a dose adjustment or special tests to safely use this medication:

  • asthma, COPD, sleep apnea, or other breathing disorders;

  • liver or kidney disease;
  • a history of head injury or brain tumor;

  • low blood pressure;

  • a stomach or intestinal disorder;

  • underactive thyroid;

  • Addison's disease or other adrenal gland disorder;

  • curvature of the spine;

  • mental illness; or

  • a history of drug or alcohol addiction.

Tell your doctor if you drink more than three alcoholic beverages per day or if you have ever had alcoholic liver disease (cirrhosis). You may not be able to take medication that contains acetaminophen.

FDA pregnancy category C. It is not known whether this medication is harmful to an unborn baby, but it could cause breathing problems or addiction/withdrawal symptoms in a newborn. Before you take acetaminophen and hydrocodone, tell your doctor if you are pregnant or plan to become pregnant during treatment. Acetaminophen and hydrocodone can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take acetaminophen and hydrocodone?

Take this medication exactly as it was prescribed for you. Do not take it in larger amounts, or use it for longer than recommended by your doctor. Follow the directions on your prescription label. Tell your doctor if the medicine seems to stop working as well in relieving your pain.

An overdose of acetaminophen can cause serious harm to your liver. The maximum amount of acetaminophen for adults is 1 gram (1000 mg) per dose and 4 grams (4000 mg) per day. One acetaminophen and hydrocodone tablet may contain up to 750 mg of acetaminophen. Know the amount of acetaminophen in the specific product you are taking.

Measure the liquid form of this medication with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.

Drink 6 to 8 full glasses of water daily to help prevent constipation while you are taking acetaminophen and hydrocodone. Ask your doctor about ways to increase the fiber in your diet. Do not use a stool softener (laxative) without first asking your doctor. You may have withdrawal symptoms when you stop using acetaminophen and hydrocodone after using it over a long period of time. Do not stop using this medication suddenly without first talking to your doctor. You may need to use less and less before you stop the medication completely.

This medication can cause you to have unusual results with certain urine tests. Tell any doctor who treats you that you are using acetaminophen and hydrocodone.

If you need to have any type of surgery, tell the surgeon ahead of time that you are using acetaminophen and hydrocodone. You may need to stop using the medicine for a short time.

Store acetaminophen and hydrocodone at room temperature away from moisture and heat.

Keep track of how many tablets have been used from each new bottle of this medicine. Hydrocodone is a drug of abuse and you should be aware if any person in the household is using this medicine improperly or without a prescription.

See also: Acetaminophen and hydrocodone dosage in more detail

What happens if I miss a dose?

Since acetaminophen and hydrocodone is taken as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and wait until your next regularly scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. An overdose of acetaminophen and hydrocodone can be fatal.

The first signs of an acetaminophen overdose include loss of appetite, nausea, vomiting, stomach pain, sweating, and confusion or weakness. Later symptoms may include pain in your upper stomach, dark urine, and yellowing of your skin or the whites of your eyes.

Overdose symptoms may also include extreme drowsiness, pinpoint pupils, cold and clammy skin, muscle weakness, fainting, weak pulse, slow heart rate, coma, blue lips, shallow breathing, or no breathing

What should I avoid while taking acetaminophen and hydrocodone?

This medication can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Do not use any other cold, allergy, pain, or sleep medication without first asking your doctor or pharmacist. Acetaminophen (sometimes abbreviated as "APAP") is contained in many combination medicines. If you use certain products together you may accidentally use too much acetaminophen. Read the label of any other medicine you are using to see if it contains acetaminophen or APAP. Avoid drinking alcohol while taking acetaminophen and hydrocodone. Alcohol may increase your risk of liver damage while taking acetaminophen. Cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, antidepressants, or seizure medication can add to sleepiness caused by hydrocodone, or could slow your breathing. Tell your doctor if you need to use any of these other medicines while you are taking acetaminophen and hydrocodone.

Acetaminophen and hydrocodone side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:
  • shallow breathing, slow heartbeat;

  • feeling light-headed, fainting;

  • confusion, fear, unusual thoughts or behavior;

  • seizure (convulsions);

  • problems with urination; or

  • nausea, stomach pain, loss of appetite, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious side effects may include:

  • feeling anxious, dizzy, or drowsy;

  • mild nausea, vomiting, upset stomach, constipation;

  • headache, mood changes;

  • blurred vision;

  • ringing in your ears; or

  • dry mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Acetaminophen and hydrocodone Dosing Information

Usual Adult Dose for Pain:

Initial dose:1 tablet (acetaminophen/hydrocodone 500 mg-5 mg) orally every 6 hours as needed or10 mL (acetaminophen/hydrocodone 333 mg-5 mg) oral elixir every 6 hours as needed or15 mL (acetaminophen/hydrocodone 325 mg-10 mg) oral solution every 4 to 6 hours as needed or15 mL (acetaminophen/hydrocodone 500 mg-10 mg) oral elixir every 4 to 6 hours as needed.Many different combination dosage forms of acetaminophen-hydrocodone are commercially available. In general, combinations with 5 mg of hydrocodone are given 1 to 2 doses every 4 to 6 hours, up to 8 doses per day. Combinations containing 7.5 or 10 mg of hydrocodone are given once every 4 to 6 hours, up to 5 or 6 doses per day (depending on how much acetaminophen they contain).

Usual Geriatric Dose for Pain:

Initial dose: 1 tablet (acetaminophen/hydrocodone 500 mg-2.5 mg) orally every 6 hours as needed or 5 mL (acetaminophen/hydrocodone 167 mg-2.5 mg) oral elixir every 6 hours as needed.

Usual Pediatric Dose for Cough:

greater than or equal to 2 years; less than or equal to 40 kg: 0.135 mg/kg of hydrocodone every 4 to 6 hours as needed.(Do not exceed 5 mg of hydrocodone/single dose.)greater than or equal to 2 years; greater than 40 kg: 0.135 mg/kg of hydrocodone every 4 to 6 hours as needed. (Do not exceed 7.5 mg of hydrocodone/single dose.)

Usual Pediatric Dose for Pain:

greater than or equal to 2 years; less than or equal to 40 kg: 0.135 mg/kg of hydrocodone every 4 to 6 hours as needed.(Do not exceed 5 mg of hydrocodone/single dose.)greater than or equal to 2 years; greater than 40 kg: 0.135 mg/kg of hydrocodone every 4 to 6 hours as needed. (Do not exceed 7.5 mg of hydrocodone/single dose.)

What other drugs will affect acetaminophen and hydrocodone?

Before taking this medication, tell your doctor if you are using any of the following drugs:

  • an antidepressant such as amitriptyline (Elavil, Etrafon), clomipramine (Anafranil), imipramine (Janimine, Tofranil), and others;

  • an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate);

  • atropine (Donnatal, and others), benztropine (Cogentin), dimenhydrinate (Dramamine), glycopyrrolate (Robinul), mepenzolate (Cantil), methscopolamine (Pamine), or scopolamine (Transderm-Scop);

  • bladder or urinary medications such as darifenacin (Enablex), flavoxate (Urispas), oxybutynin (Ditropan, Oxytrol), tolterodine (Detrol), or solifenacin (Vesicare);

  • a bronchodilator such as ipratropium (Atrovent) or tiotropium (Spiriva); or

  • irritable bowel medications such as dicyclomine (Bentyl), hyoscyamine (Anaspaz, Cystospaz, Levsin, and others), or propantheline (Pro-Banthine).

This list is not complete and there may be other drugs that can interact with acetaminophen and hydrocodone. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

  • Your pharmacist can provide more information about acetaminophen and hydrocodone.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2006 Cerner Multum, Inc. Version: 9.01. Revision Date: 07/29/2009 10:02:27 AM.

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