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Drugs reference index «Novantrone»



Generic Name: Mitoxantrone (mye-toe-ZAN-trone)Brand Name: Novantrone

Novantrone may cause severe blood disorders, such as bone marrow suppression (which decreases your body's ability to fight infection), or cause you bruise or bleed easily. Tell your doctor if you experience fever, chills, sore throat, or unusual bruising or bleeding. Novantrone may cause severe and life-threatening heart problems. Heart problems may occur during therapy or sometimes months to years after receiving Novantrone , and may occur even if you do not have any risk factors. Risk may increase with higher doses of Novantrone . Before using Novantrone , tell your doctor if you have a history of heart problems, radiation therapy, or treatment with anthracyclines (eg, doxorubicin), other similar medicines, or medicines that may cause heart problems. Talk to your doctor if you are unsure if any of your medicines may cause heart problems. Tell your doctor if you experience swelling of the hands or feet, shortness of breath, or sudden weight gain.

Complete blood counts and heart function tests may be performed to monitor for side effects.

Rarely, treatment with Novantrone may result in the development of a secondary cancer. Your risk may be increased if you are taking certain other cytotoxic medicines. Tell your doctor if you have a history of taking cytotoxic medicines.

Novantrone is used for:

Reducing disability and the number of relapses in certain patients with multiple sclerosis. It is used along with other medicine(s) to treat acute nonlymphotcytic leukemia or advanced prostate cancer in certain patients. It may also be used for other conditions as determined by your doctor.

Novantrone is an antineoplastic agent. How it works is not fully understood. It is thought to interfere with cell reproduction and growth, which helps reduce the number of cancer cells in the body.

Do NOT use Novantrone if:

  • you are allergic to any ingredient in Novantrone
  • you have multiple sclerosis along with certain heart problems

Contact your doctor or health care provider right away if any of these apply to you.

Before using Novantrone :

Some medical conditions may interact with Novantrone . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have chickenpox, herpes, bone marrow depression, liver problems, heart problems, or gout
  • if you have previously received chemotherapy or have received radiation therapy in the chest area

Some MEDICINES MAY INTERACT with Novantrone . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Cyclosporine because the risk of Novantrone 's side effects may be increased
  • Digoxin or hydantoins (eg, phenytoin) because their effectiveness may be decreased by Novantrone

This may not be a complete list of all interactions that may occur. Ask your health care provider if Novantrone may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Novantrone :

Use Novantrone as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Novantrone is usually administered as an injection at your doctor's office, hospital, or clinic. If you are using Novantrone at home, carefully follow the injection procedures taught to you by your health care provider.
  • If Novantrone contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.
  • Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal.
  • If you miss a dose of Novantrone , contact your doctor right away.

Ask your health care provider any questions you may have about how to use Novantrone .

Important safety information:

  • Novantrone will turn your urine a blue-green color. It may also cause the whites of your eyes to turn a bluish color. This is normal and not a cause for concern.
  • Novantrone may lower your body's ability to fight infection. Prevent infection by avoiding contact with people with colds or other infections. Notify your doctor of any signs of infection, including fever, sore throat, rashes, or chills.
  • Avoid vaccinations with live virus vaccines (eg, measles, mumps, oral polio) while you are taking Novantrone . Vaccinations may be less effective.
  • Novantrone may reduce the number of clot-forming cells (platelets) in your blood. To prevent bleeding, avoid situations in which bruising or injury may occur. Report any unusual bleeding, bruising, blood in stools, or dark, tarry stools to your doctor.
  • Some patients using Novantrone have developed a type of leukemia. Discuss any questions or concerns with your doctor.
  • Lab tests, including complete blood cell counts, liver function tests, blood chemistry, pregnancy tests, uric acid levels, and heart function tests, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
  • Novantrone is not recommended for use in CHILDREN. Safety and effectiveness have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: Novantrone has been shown to cause harm to the fetus. If you become pregnant, discuss with your doctor the benefits and risks of using Novantrone during pregnancy. It is unknown if Novantrone is excreted in breast milk. Do not breast-feed while taking Novantrone .

Possible side effects of Novantrone :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Back pain; blue-green urine; bluish-colored whites of the eyes; constipation; cough; diarrhea; hair loss or thinning; loss of appetite; loss of menstrual period; menstrual changes; mouth pain; nausea; stomach pain or upset; stuffy nose; tiredness; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; dark, pink, or bloody urine; fast or irregular heartbeat; fever, chills, sore throat, or persistent cough; increased, decreased, or painful urination; mental or mood changes (eg, anxiety, depression); mouth sores, inflammation, or severe pain; pain, swelling, or redness at the injection site; severe or persistent tiredness or weakness; shortness of breath; sinus infection; sudden, unexplained weight gain; swelling of hands, legs, or feet; unusual bruising or bleeding; vision changes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately.

Proper storage of Novantrone :

Novantrone is usually handled and stored by a health care provider. If you are using Novantrone at home, store Novantrone as directed by your pharmacist or health care provider. Keep Novantrone out of the reach of children and away from pets.

General information:

  • If you have any questions about Novantrone , please talk with your doctor, pharmacist, or other health care provider.
  • Novantrone is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Novantrone . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

  • Novantrone Advanced Consumer (Micromedex) - Includes Dosage Information
  • Novantrone Concise Consumer Information (Cerner Multum)
  • Novantrone Prescribing Information (FDA)
  • Mitoxantrone Professional Patient Advice (Wolters Kluwer)
  • Mitoxantrone Prescribing Information (FDA)

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