Olanzapine Generic Name:
Olanzapine (oh-LAN-za-peen)Brand Name:
Olanzapine is an antipsychotic. It may increase the risk of death when used to treat mental problems caused by dementia in elderly patients. Most of the deaths were linked to heart problems or infection. Olanzapine is not approved to treat mental problems caused by dementia.
Olanzapine is used for:
Short-term treatment of agitation caused by schizophrenia or bipolar disorder. It may also be used for other conditions as determined by your doctor.
Olanzapine is an atypical antipsychotic. Exactly how it works is not known. It is thought to affect certain substances in the brain.
Do NOT use Olanzapine if:
- you are allergic to any ingredient in Olanzapine
Contact your doctor or health care provider right away if any of these apply to you.
Before using Olanzapine :
Some medical conditions may interact with Olanzapine . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have a history of seizures, heart problems (eg, fast, slow, or irregular heartbeat; heart failure), abnormal electrocardiogram (ECG), heart attack, stroke or mini-stroke, blood vessel problems, high blood cholesterol levels, high or low blood pressure, or low white blood cell levels
- if you have a history of liver problems, stomach or bowel problems (eg, decreased muscle movement), enlarged prostate, narrow-angle glaucoma, neuroleptic malignant syndrome (NMS), aspiration pneumonia, or suicidal thoughts or attempts
- if you have Alzheimer disease, bowel blockage, dementia, or trouble swallowing
- if you have diabetes or are very overweight, or if a family member has had diabetes
- if you have had high blood prolactin levels or a history of certain types of cancer (eg, breast, pancreas, pituitary), or if you are at risk for breast cancer
- if you are dehydrated, drink alcohol, or smoke, or you will be exposed to high temperatures
Some MEDICINES MAY INTERACT with Olanzapine . Tell your health care provider if you are taking any other medicines, especially any of the following:
- Alpha blockers (eg, doxazosin), diazepam, or medicine for high blood pressure because the risk of low blood pressure and fainting may be increased
- Anticholinergics (eg, scopolamine), benzodiazepines (eg, lorazepam), or fluvoxamine because they may increase the risk of Olanzapine 's side effects
- Carbamazepine, HIV protease inhibitors (eg, ritonavir), omeprazole, or rifampin because they may decrease Olanzapine 's effectiveness
- Dopamine receptor agonists (eg, pramipexole) or levodopa because their effectiveness may be decreased by Olanzapine
This may not be a complete list of all interactions that may occur. Ask your health care provider if Olanzapine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Olanzapine :
Use Olanzapine as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Olanzapine is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Olanzapine at home, a health care provider will teach you how to use it. Be sure you understand how to use Olanzapine . Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
- Do not use Olanzapine if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
- If you miss a dose of Olanzapine , contact your doctor right away.
Ask your health care provider any questions you may have about how to use Olanzapine .
Important safety information:
- Olanzapine may cause dizziness, drowsiness, or decreased vision. These effects may be worse if you take it with alcohol or certain medicines. Use Olanzapine with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Do not drink alcohol while you are using Olanzapine .
- Talk with your doctor before you use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Olanzapine ; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
- Olanzapine may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects. Tell your doctor or other health care provider if these effects occur.
- Do not become overheated in hot weather or while you are being active; heatstroke may occur.
- Olanzapine may raise your blood sugar. High blood sugar may make you feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. If these symptoms occur, tell your doctor right away.
- Olanzapine may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.
- Neuroleptic malignant syndrome (NMS) is a possibly fatal syndrome that can be caused by Olanzapine . Symptoms may include fever; stiff muscles; confusion; abnormal thinking; fast or irregular heartbeat; and sweating. Contact your doctor at once if you have any of these symptoms.
- Some patients who take Olanzapine may develop muscle movements that they cannot control. This is more likely to happen in elderly patients, especially women. The chance that this will happen or that it will become permanent is greater in those who take Olanzapine in higher doses or for a long time. Muscle problems may also occur after short-term treatment with low doses. Tell your doctor at once if you have muscle problems with your arms; legs; or your tongue, face, mouth, or jaw (eg, chewing movements, mouth puckering, puffing of cheeks, tongue sticking out) while taking Olanzapine .
- Lab tests, including fasting blood glucose, cholesterol, complete blood cell counts, and liver function, may be performed while you use Olanzapine . These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Use Olanzapine with caution in the ELDERLY; they may be more sensitive to its effects.
- Olanzapine should not be used in CHILDREN younger than 18 years old; safety and effectiveness in these children have not been confirmed.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Olanzapine while you are pregnant. Olanzapine is found in breast milk. Do not breast-feed while taking Olanzapine .
Possible side effects of Olanzapine :
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Dizziness; drowsiness; lightheadedness; pain, redness, or swelling at the injection site; weakness.Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); abnormal thoughts; chest pain; confusion; decreased urination; fainting; fast, slow, or irregular heartbeat; fever, chills, or persistent sore throat; increased saliva production or drooling; increased sweating; memory loss; menstrual changes; muscle pain, weakness, or stiffness; new or worsening mental or mood changes (eg, depression, hallucinations); seizures; severe or prolonged dizziness or headache; shortness of breath; suicidal thoughts or actions; swelling of the hands, legs, or feet; symptoms of high blood sugar (eg, increased thirst, hunger, urination, unusual weakness); tremor; trouble concentrating, speaking, or swallowing; trouble sitting still; trouble walking or standing; uncontrolled muscle movements (eg, arm or leg movements, twitching of the face or tongue, jerking or twisting); unusual bruising; vision changes; yellowing of the skin or eyes.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include aggression; agitation; chest pain; coma; difficult or slurred speech; fast or irregular heartbeat; seizure; severe drowsiness; slow or shallow breathing; uncontrolled muscle movements.Proper storage of Olanzapine :
Olanzapine is usually handled and stored by a health care provider. If you are using Olanzapine at home, store Olanzapine as directed by your pharmacist or health care provider. Keep Olanzapine out of the reach of children and away from pets.
- If you have any questions about Olanzapine , please talk with your doctor, pharmacist, or other health care provider.
- Olanzapine is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
This information is a summary only. It does not contain all information about Olanzapine . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.
- Olanzapine Professional Patient Advice (Wolters Kluwer)
- Olanzapine Detailed Consumer Information (PDR)
- olanzapine Advanced Consumer (Micromedex) - Includes Dosage Information
- Zyprexa Consumer Overview
- Zyprexa Prescribing Information (FDA)
- Zyprexa Relprevv Prescribing Information (FDA)
- Zyprexa Relprevv Advanced Consumer (Micromedex) - Includes Dosage Information
- Zyprexa Relprevv Consumer Overview