Trade Names:Tylenol w/Codeine- Elixir 12 mg codeine phosphate/120 mg acetaminophen
Trade Names:Capital w/Codeine- Suspension 12 mg codeine phosphate/120 mg acetaminophen
Trade Names:Tylenol w/Codeine No. 2- Tablets 15 mg codeine phosphate/300 mg acetaminophen
Trade Names:Aceta w/ Codeine- Tablets 30 mg codeine phosphate/300 mg acetaminophen
Trade Names:Tylenol w/Codeine No. 3- Tablets 30 mg codeine phosphate/300 mg acetaminophen
Trade Names:Phenaphen w/Codeine No. 3- Capsules 30 mg codeine phosphate/325 mg acetaminophen
Trade Names:Tylenol w/Codeine No. 4- Tablets 60 mg codeine phosphate/300 mg acetaminophen
Trade Names:Phenaphen w/Codeine No. 4- Capsules 60 mg codeine phosphate/325 mg acetaminophenratio-Emtec-30 (Canada)ratio-Lenoltec No. 4 (Canada)Triatec-30 (Canada)
Inhibits synthesis of prostaglandins; binds to opiate receptors in CNS and peripherally blocks pain impulse generation; produces antipyresis by direct action on hypothalamic heat-regulating center; causes cough suppression by direct central action in medulla; may produce generalized CNS depression; does not have significant anti-inflammatory or antiplatelet effects.
Relief of mild to moderate pain; analgesic-antipyretic therapy in presence of aspirin allergy, hemostatic disturbances, bleeding diatheses, upper GI disease and gouty arthritis.
Hypersensitivity to codeine phosphate or similar compounds.
Tylenol No. 2 equals 15 mg codeine, 300 mg acetaminophen. Tylenol No. 3 equals 30 mg codeine, 300 mg acetaminophen. Tylenol No. 4 equals 60 mg codeine, 300 mg acetaminophen.Max adult dose
Codeine equals 360 mg/day; acetaminophen equals 4 g/day.TabletsAdults
PO Usually 1 to 2 tablets every 4 h (varies according to product).Children younger than 12 yr of age
PO 0.5 to 1 mg codeine/kg/dose every 4 to 6 h; 10 to 15 mg acetaminophen/kg/dose every 4 h to max 2.6 g/24 h.ElixirChildren older than 12 yr of age
PO 15 mL every 4 h as needed.Children 7 to 12 yr of age
PO 10 mL 3 times daily to 4 times daily as needed.Children 3 to 6 yr of age
PO 5 mL 3 times daily to 4 times daily as needed.
Store in air tight, light-resistant container at room temperature.
May result in increased risk of hepatotoxicity.Cimetidine
Effects of codeine may be enhanced, increasing toxicity.CNS depressants (eg, barbiturates, ethyl alcohol, other narcotics)
May result in additive CNS depressant effects and toxicity.Tricyclic antidepressants, phenothiazines
May cause additive CNS depressant effects and toxicity.
With Chemstrip bG , Dextrostix , and Visidex II home blood glucose systems, drug may cause false decrease in mean glucose values. False-positive results may occur in urinary 5-hydroxy-indoleacetic acid test.
Lightheadedness; dizziness; sedation; euphoria; insomnia; disorientation; incoordination.
Nausea; vomiting; dry mouth; constipation; abdominal pain.
Dyspnea; respiratory depression; decreased cough reflex.
Category C .
Excreted in breast milk.
Acetaminophen intake must be limited to 2 g/day or less.
Caution is needed with sulfite sensitive patients; some commercial preparations contain sodium bisulfite.
Blood dyscrasias, respiratory depression, hepatic damage (may occur up to several days after overdose).
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