pantoprazole (Intravenous route)

pan-TOE-pra-zole

Commonly used brand name(s):

In the U.S.

• Protonix

Available Dosage Forms:

• Powder for Solution

Pharmacologic Class: Proton Pump Inhibitor

Uses For pantoprazole

Pantoprazole is used to treat certain conditions in which there is too much acid in the stomach. It is used to treat gastroesophageal reflux disease (GERD), a condition in which the acid in the stomach washes back up into the esophagus. pantoprazole may also be used to treat Zollinger-Ellison syndrome or other conditions (such as cancer) in which the stomach produces too much acid .

Pantoprazole works by decreasing the amount of acid produced by the stomach.

pantoprazole is available only with your doctor's prescription.

Before Using pantoprazole

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For pantoprazole, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to pantoprazole or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of pantoprazole in the pediatric population. Safety and efficacy have not been established .

Geriatric

Appropriate studies performed to date have not demonstrated geriatrics-specific problems that would limit the usefulness of pantoprazole in the elderly .

Pregnancy

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Using pantoprazole with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Atazanavir
• Clopidogrel
• Dasatinib
• Erlotinib
• Mycophenolate Mofetil
• Nelfinavir

Using pantoprazole with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Cranberry
• Itraconazole
• Methotrexate
• Warfarin

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of pantoprazole. Make sure you tell your doctor if you have any other medical problems, especially:

• Liver disease —This condition may cause pantoprazole to build up in the body.

• Zinc deficiency, or prone to—May make your condition worse.

Proper Use of pantoprazole

It may take several days before pantoprazole begins to relieve stomach pain. To help relieve this pain, antacids may be taken with pantoprazole, unless your doctor has told you not to use them.

Tell your doctor if you have ever had problems with a lack of zinc in your body. Your doctor may have you take zinc supplements.

A nurse or other trained health professional will give you pantoprazole. pantoprazole is given through a needle placed into one of your veins .

Precautions While Using pantoprazole

It is important that your doctor check your progress at regular visits. If your condition does not improve, or if it becomes worse, check with your doctor.

pantoprazole Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• Accumulation of pus
• bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at injection site
• changes in skin color, pain, tenderness, or swelling of foot or leg
• fever
• stomach pain
• swollen, red, tender area of infection

• Abdominal pain
• absence of or decrease in body movement
• blindness
• blistering, peeling, loosening of skin
• bloating of abdomen
• bloody or cloudy urine
• bloody, black, or tarry stools
• blurred vision
• chills
• constipation
• continuing ringing or buzzing or other unexplained noise in ears
• cough
• dark-colored urine
• decreased vision
• diarrhea
• difficulty in speaking
• difficulty swallowing
• dizziness or lightheadedness
• fast heartbeat
• feeling of constant movement of self or surroundings
• greatly decreased frequency of urination or amount of urine
• hearing loss
• hives
• increased watering of the mouth
• indigestion
• itching
• joint or muscle pain
• large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
• light-colored stools
• loss of appetite
• mood or mental changes
• muscle cramps or spasms
• muscle pain or stiffness
• nausea or vomiting
• pains in stomach, side, or abdomen, possibly radiating to the back
• pale skin
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• red skin lesions, often with a purple center
• red, irritated eyes
• sensation of spinning
• shortness of breath
• skin rash
• sore throat
• sores, ulcers, or white spots on lips or in mouth
• swelling of feet or lower legs
• swollen glands
• tightness in chest
• unexplained bleeding or bruising
• unusual tiredness or weakness
• vomiting
• wheezing
• yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Acid or sour stomach
• belching
• difficulty having a bowel movement (stool)
• dizziness
• headache
• heartburn
• indigestion
• runny nose
• sleeplessness
• sneezing
• stomach discomfort, upset, or pain
• stuffy nose
• trouble sleeping
• unable to sleep

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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