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Drugs reference index «Parnate»



Generic Name: Tranylcypromine (tran-ill-SIP-row-meen)Brand Name: Parnate

Antidepressants may increase the risk of suicidal thoughts or actions in children, teenagers, and young adults. However, depression and certain other mental problems may also increase the risk of suicide. Talk with the patient's doctor to be sure that the benefits of using Parnate outweigh the risks.

Family and caregivers must closely watch patients who take Parnate . It is important to keep in close contact with the patient's doctor. Tell the doctor right away if the patient has symptoms like worsened depression, suicidal thoughts, or changes in behavior. Discuss any questions with the patient's doctor.

Parnate is used for:

Treating depression. It may also be used for other conditions as determined by your doctor.

Parnate is a monoamine oxidase inhibitor (MAOI). It works by blocking the action of the enzyme (monoamine oxidase) that breaks down the body's mood-elevating chemicals (dopamine, norepinephrine, and serotonin). This produces an increase in the activity of these mood-elevating chemicals.

Do NOT use Parnate if:

  • you are allergic to any ingredient in Parnate
  • you have a history of stroke, heart disease, congestive heart failure, a brain disease, headaches, liver disease or abnormal liver function tests, high blood pressure, or an adrenal gland tumor (pheochromocytoma)
  • you will be having surgery
  • you eat foods with a high tyramine content (eg, aged cheeses, sour cream, red wines, beer, bologna, pepperoni, salami, summer sausage, pickled herring, liver, meat prepared with tenderizers, canned figs, raisins, bananas, avocados, soy sauce, fava beans, yeast extracts). Ask your health care provider for a complete list of foods you should avoid.
  • you drink alcohol or consume large quantities of caffeine (coffee, tea, chocolate, or cola)
  • you are taking an amphetamine (eg, methylphenidate), an anesthetic, an antihistamine (eg, loratadine), apraclonidine, brimonidine, bupropion, buspirone, carbamazepine, certain herbal products (eg, ma huang), cyclobenzaprine, dextromethorphan, dibenzazepine, a diuretic (eg, hydrochlorothiazide), entacapone, indoramin, medicines for Parkinson disease (eg, levodopa), meperidine, a narcotic (eg, codeine), nefazodone, papaverine, a selective serotonin reuptake inhibitor (SSRI) (eg, fluoxetine, citalopram), a serotonin norepinephrine reuptake inhibitor (SNRI) (eg, duloxetine, venlafaxine), a sedative, sibutramine, a sympathomimetic (eg, pseudoephedrine), tolcapone, tramadol, a tricyclic antidepressant (eg, amitriptyline, doxepin), a triptan (eg, sumatriptan, zolmitriptan), or another MAOI (eg, phenelzine)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Parnate :

Some medical conditions may interact with Parnate . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have asthma, diabetes, bipolar mood disorder, bronchitis, an irregular heartbeat, diabetes, epilepsy, an overactive thyroid, Parkinson disease, the blood disease porphyria, kidney problems, heart problems, or a history of suicidal thoughts or behaviors
  • if you have a history of substance or alcohol abuse or dependence

Some MEDICINES MAY INTERACT with Parnate . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Many prescription and nonprescription medicines (eg, used for diabetes, depression, Parkinson disease, headaches, pain, cold and flu, high blood pressure, seizures) may interact with Parnate and increase the risk of serious, life-threatening side effects

This may not be a complete list of all interactions that may occur. Ask your health care provider if Parnate may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Parnate :

Use Parnate as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Parnate comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Parnate refilled.
  • Take Parnate by mouth with or without food.
  • Continue to take Parnate even if you feel well. Do not miss any doses.
  • If you miss a dose of Parnate , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Parnate .

Important safety information:

  • Parnate may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Parnate with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Eating foods high in tyramine (eg, aged cheeses, red wines, beer, certain meats and sausages, liver, sour cream, soy sauce, raisins, bananas, avocados) while you use an MAOI may cause severe high blood pressure. This could occur for up to 2 weeks after you stop taking an MAOI. Do not eat foods high in tyramine while you take Parnate . Ask your health care provider for a complete list of foods you should avoid. Seek medical attention at once if symptoms of severe high blood pressure occur. These may include severe headache, fast or irregular heartbeat, sore or stiff neck, nausea, vomiting, sweating, enlarged pupils, or sensitivity to light.
  • Avoid large amounts of food or drink that have caffeine (eg, coffee, tea, cocoa, cola, chocolate).
  • Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Parnate ; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
  • Parnate may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
  • Children and teenagers who take Parnate may be at increased risk for suicidal thoughts or actions. Adults may also be affected. The risk may be greater in patients who have had suicidal thoughts or actions in the past. The risk may also be greater in patients who have had bipolar (manic-depressive) illness, or if their family members have had it. Watch patients who take Parnate closely. Contact the doctor at once if new, worsened, or sudden symptoms such as depressed mood; anxious, restless, or irritable behavior; panic attacks; or any unusual change in mood or behavior occur. Contact the doctor right away if any signs of suicidal thoughts or actions occur.
  • Parnate may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Parnate . Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
  • Tell your doctor or dentist that you take Parnate before you receive any medical or dental care, emergency care, or surgery.
  • Before you begin taking any new medicine, either prescription or nonprescription, check with your doctor or pharmacist.
  • Diabetes patients - Parnate may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • Lab tests, including blood pressure monitoring, may be performed while you use Parnate . These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Parnate with caution in the ELDERLY; they may be more sensitive to its effects, especially difficulty sleeping and enlarged prostate.
  • Parnate should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed. CHILDREN taking Parnate may be at increased risk of suicidal thoughts and behaviors.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Parnate while you are pregnant. Parnate is found in breast milk. Do not breast-feed while taking Parnate .

If you stop taking Parnate suddenly, you may have WITHDRAWAL symptoms. These may include restlessness, anxiety, depression, confusion, hallucinations, headache, weakness, and diarrhea.

Possible side effects of Parnate :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Blurred vision; constipation; diarrhea; drowsiness; dry mouth; stomach pain; tremors; upset stomach; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); agitation or anxiety; bizarre behavior; blurred vision; chest pain; difficulty sleeping; dilated pupils; dizziness; fainting; fast, slow, or irregular heartbeat; feelings of irritability and hostility; fever; headache; impulsive behavior or other unusual changes in behavior; nausea; panic attacks; pounding in the chest; sensitivity to light; severe nervousness or anxiety; severe restlessness; sleeplessness; sore or stiff neck; sweating (sometimes with fever or cold, clammy skin); thoughts of suicide; vomiting; worsening feelings of depression.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include confusion; dizziness; drowsiness; excitement; fast heartbeat; flushing; headache; irritability; restlessness; seizures; sweating; weakness.

Proper storage of Parnate :

Store Parnate at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Parnate out of the reach of children and away from pets.

General information:

  • If you have any questions about Parnate , please talk with your doctor, pharmacist, or other health care provider.
  • Parnate is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Parnate . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

  • Parnate Prescribing Information (FDA)
  • Parnate Advanced Consumer (Micromedex) - Includes Dosage Information
  • Parnate Detailed Consumer Information (PDR)
  • Parnate Concise Consumer Information (Cerner Multum)
  • Tranylcypromine Prescribing Information (FDA)

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