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Drugs reference index «paromomycin»

paromomycin


paromomycin

Generic Name: paromomycin (PAR oh moe MYE sin)Brand names: Paromycin, Humatin

What is paromomycin?

Paromomycin is an antibiotic.

Paromomycin is used in the treatment of various intestinal infections. Paromomycin is also used in the treatment of certain liver problems.

Paromomycin may also be used for purposes other than those listed here.

What is the most important information I should know about paromomycin?

Use caution when driving, operating machinery, or performing other hazardous activities. Paromomycin may cause dizziness. If you experience dizziness, avoid these activities and contact your doctor.

What should I discuss with my healthcare provider before taking paromomycin?

Before taking paromomycin, tell your doctor if you have

  • stomach or intestinal problems such as stomach ulcer, inflammatory bowel disease, or intestinal blockage (obstruction);

  • kidney disease; or
  • liver disease.

You may not be able to take paromomycin, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

Do not take paromomycin without first talking to your doctor if you are pregnant or could become pregnant during treatment. Do not take paromomycin without first talking to your doctor if you are breast-feeding a baby.

How should I take paromomycin?

Take paromomycin exactly as directed by your doctor. If you do not understand these instructions, ask your doctor, nurse, or pharmacist to explain them to you.

Take each dose with a full glass of water. Take paromomycin with food.

It is important to take paromomycin regularly to get the most benefit.

Store paromomycin at room temperature away from moisture, heat, and direct light.

See also: Paromomycin dosage in more detail

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for the next dose, skip the dose you missed and take only the next regularly scheduled dose. Do not take a double dose unless otherwise directed by your doctor.

What happens if I overdose?

Seek emergency medical attention if an overdose is suspected.

Symptoms of a paromomycin overdose are not known.

What should I avoid while taking paromomycin?

Use caution when driving, operating machinery, or performing other hazardous activities. Paromomycin may cause dizziness. If you experience dizziness, avoid these activities and contact your doctor.

Paromomycin side effects

If you experience any of the following serious side effects, seek emergency medical attention or contact your doctor immediately:
  • an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);

  • decreased hearing or ringing in the ears;

  • little or no urine production; or

  • dizziness.

Other less serious side effects may be more likely to occur. Continue to take paromomycin and talk to your doctor if you experience

  • nausea or vomiting;

  • diarrhea; or

  • itching.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Paromomycin Dosing Information

Usual Adult Dose for Amebiasis:

25 to 35 mg/kg/day orally in 3 divided doses with meals for 5 to 10 days. Should be used following a course of metronidazole for the treatment of mild to severe, symptomatic disease. Paromomycin is not effective in extraintestinal amebiasis.

Usual Adult Dose for Cryptosporidiosis:

25 to 35 mg/kg/day orally in 2 to 4 divided doses with meals for 10 to 14 days (investigational). Has occasionally been used for up to 4 to 6 weeks or longer in AIDS patients.

Usual Adult Dose for Dientamoeba fragilis:

25 to 35 mg/kg/day orally in 3 divided doses with meals for 7 days (unlabeled use).

Usual Adult Dose for Giardiasis:

25 to 35 mg/kg/day orally in 3 divided doses with meals for 7 days (investigational). Paromomycin is an alternative for the treatment of giardiasis. Metronidazole is generally considered the drug of choice.

Usual Adult Dose for Hymenolepis nana (Dwarf Tapeworm):

45 mg/kg orally once a day for 5 to 7 days (unlabeled use). Paromomycin is not the treatment of choice.

Usual Adult Dose for Diphyllobothrium latum (Fish Tapeworm):

1 g orally every 15 minutes for 4 doses (unlabeled use). Paromomycin is not the treatment of choice.

Usual Adult Dose for Dipylidium caninum (Dog Tapeworm):

1 g orally every 15 minutes for 4 doses (unlabeled use). Paromomycin is not the treatment of choice.

Usual Adult Dose for Taenia saginata (beef tapeworm):

1 g orally every 15 minutes for 4 doses (unlabeled use). Paromomycin is not the treatment of choice.

Usual Adult Dose for Taenia solium (pork tapeworm):

1 g orally every 15 minutes for 4 doses (unlabeled use). Paromomycin is not the treatment of choice.

Usual Adult Dose for Hepatic Coma:

Adjunct therapy: 1 gram four times a day for 5 to 7 days

Usual Pediatric Dose for Amebiasis:

<18 years: 25 to 35 mg/kg/day orally in 3 divided doses with meals for 5 to 10 days. Should be used following a course of metronidazole for the treatment of mild to severe, symptomatic disease. Paromomycin is not effective in extraintestinal amebiasis.

Usual Pediatric Dose for Cryptosporidiosis:

25 to 35 mg/kg/day orally in 3 divided doses with meals for 10 to 14 days (investigational). Has occasionally been used for up to 4 to 6 weeks or longer in AIDS patients.

Usual Pediatric Dose for Dientamoeba fragilis:

<18 years: 25 to 35 mg/kg/day orally in 3 divided doses with meals for 7 days (unlabeled use).

Usual Pediatric Dose for Giardiasis:

<18 years: 25 to 35 mg/kg/day orally in 3 divided doses with meals for 7 days (investigational). Paromomycin is an alternative for the treatment of giardiasis. Metronidazole is generally considered the drug of choice.

Usual Pediatric Dose for Hymenolepis nana (Dwarf Tapeworm):

<18 years: 45 mg/kg orally once a day for 5-7 days (unlabeled use).

Usual Pediatric Dose for Diphyllobothrium latum (Fish Tapeworm):

<18 years: 11 mg/kg orally every 15 minutes for 4 doses (unlabeled use).

Usual Pediatric Dose for Dipylidium caninum (Dog Tapeworm):

<18 years: 11 mg/kg orally every 15 minutes for 4 doses (unlabeled use).

Usual Pediatric Dose for Taenia saginata (beef tapeworm):

<18 years: 11 mg/kg orally every 15 minutes for 4 doses (unlabeled use).

Usual Pediatric Dose for Taenia solium (pork tapeworm):

<18 years: 11 mg/kg orally every 15 minutes for 4 doses (unlabeled use).

What other drugs will affect paromomycin?

Talk to your doctor before taking any other prescription or over-the-counter medicines, including vitamins, minerals, and herbal products, during treatment with paromomycin.

Where can I get more information?

  • Your pharmacist has additional information about paromomycin written for healthcare professionals that you may read.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2006 Cerner Multum, Inc. Version: 1.04. Revision Date: 4/12/2009 4:39:05 PM.
  • Paromomycin MedFacts Consumer Leaflet (Wolters Kluwer)
  • Paromomycin Prescribing Information (FDA)
  • Humatin Prescribing Information (FDA)

See Also...

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