Trade Names:Humatin- Capsules 250 mg
Inhibits production of protein in bacteria, causing bacterial cell death.
Poorly absorbed orally.
Feces (100% unchanged).
Treatment of acute and chronic intestinal amebiasis. Adjunctive therapy in management of hepatic coma.
Treatment of other parasitic infections.
Intestinal obstruction; extraintestinal amebiasis; hypersensitivity to aminoglycosides.
PO 25 to 35 mg/kg/day in 3 divided doses with meals for 5 to 10 days.Hepatic ComaAdults
PO 4 g/day in divided doses at regular intervals for 5 to 6 days.
Store at room temperature in a tight container.
May reduce rate and extent of digoxin absorption; this may be offset by decreased digoxin metabolism.Methotrexate
Decreased absorption of methotrexate.Neuromuscular blockers
Increased action of both depolarizing and nondepolarizing neuromuscular blocking agents, may prolong need for respiratory support.Neurotoxic, nephrotoxic, or ototoxic medications (eg, polypeptide antibiotics)
Additive adverse effects may occur with concurrent or sequential administration of medications with similar toxic profiles.
None well documented.
Nausea; vomiting; abdominal cramps; anorexia; epigastric burning; pruritus ani; diarrhea.
Manifests as both auditory and vestibular ototoxicity, and primarily occurs in patients with pre-existing renal damage or with prolonged therapy. Partial or total irreversible deafness may continue to develop after drug is stopped. Other features of neurotoxicity include paresthesias, twitching, and seizures.Nephrotoxicity
Paromomycin is teratogenic in pregnancy. Closely monitor renal and eighth nerve function in patients with suspected renal function impairment. Monitor peak and trough concentrations. Renal function impairment requires dosage adjustments.
Category D .
Excreted in breast milk.
Prolonged or repeated therapy may result in bacterial or fungal overgrowth of nonsusceptible organisms and secondary infections.
Patients with muscular disorders such as myasthenia gravis or parkinsonism may have worsening of their disease because of potential effect of aminoglycosides on neuromuscular junction.
Neurotoxicity, nephrotoxicity, ototoxicity.
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