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Drugs reference index «Paromomycin Sulfate»

Paromomycin Sulfate

Pronunciation: (par-oh-moe-MY-sin SULL-fate)Class: Amebicide, Aminoglycoside

Trade Names:Humatin- Capsules 250 mg


Inhibits production of protein in bacteria, causing bacterial cell death.



Poorly absorbed orally.


Feces (100% unchanged).

Indications and Usage

Treatment of acute and chronic intestinal amebiasis. Adjunctive therapy in management of hepatic coma.

Unlabeled Uses

Treatment of other parasitic infections.


Intestinal obstruction; extraintestinal amebiasis; hypersensitivity to aminoglycosides.

Dosage and Administration

Intestinal AmebiasisAdults and Children

PO 25 to 35 mg/kg/day in 3 divided doses with meals for 5 to 10 days.

Hepatic ComaAdults

PO 4 g/day in divided doses at regular intervals for 5 to 6 days.


Store at room temperature in a tight container.

Drug Interactions


May reduce rate and extent of digoxin absorption; this may be offset by decreased digoxin metabolism.


Decreased absorption of methotrexate.

Neuromuscular blockers

Increased action of both depolarizing and nondepolarizing neuromuscular blocking agents, may prolong need for respiratory support.

Neurotoxic, nephrotoxic, or ototoxic medications (eg, polypeptide antibiotics)

Additive adverse effects may occur with concurrent or sequential administration of medications with similar toxic profiles.

Laboratory Test Interactions

None well documented.

Adverse Reactions


Nausea; vomiting; abdominal cramps; anorexia; epigastric burning; pruritus ani; diarrhea.


Malabsorption syndrome.




Manifests as both auditory and vestibular ototoxicity, and primarily occurs in patients with pre-existing renal damage or with prolonged therapy. Partial or total irreversible deafness may continue to develop after drug is stopped. Other features of neurotoxicity include paresthesias, twitching, and seizures.


Usually reversible.

Paromomycin is teratogenic in pregnancy. Closely monitor renal and eighth nerve function in patients with suspected renal function impairment. Monitor peak and trough concentrations. Renal function impairment requires dosage adjustments.


Category D .


Excreted in breast milk.


Prolonged or repeated therapy may result in bacterial or fungal overgrowth of nonsusceptible organisms and secondary infections.

Muscular disorders

Patients with muscular disorders such as myasthenia gravis or parkinsonism may have worsening of their disease because of potential effect of aminoglycosides on neuromuscular junction.



Neurotoxicity, nephrotoxicity, ototoxicity.

Patient Information

  • Stress to patient the importance of taking full course of therapy.
  • Emphasize to patient the importance of personal hygiene, especially handwashing.
  • Explain to patient the symptoms of superinfection and ask patient to watch for symptoms if on prolonged therapy.
  • Instruct patient to report the following symptoms to health care provider: ringing in ears, hearing impairment, or dizziness.

Copyright © 2009 Wolters Kluwer Health.

  • Paromomycin Prescribing Information (FDA)
  • Humatin Prescribing Information (FDA)
  • Humatin Concise Consumer Information (Cerner Multum)
  • Humatin MedFacts Consumer Leaflet (Wolters Kluwer)

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