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Drugs reference index «Percodan»



Generic name: Oxycodone, AspirinBrand names: Percodan

Why is Percodan prescribed?

Percodan combines two pain-killing drugs: the narcotic analgesic oxycodone, and the common pain reliever aspirin. It is prescribed for moderate to moderately severe pain.

Most important fact about Percodan

The oxycodone in Percodan can cause physical and psychological dependence. Use this product with caution.

How should you take Percodan?

Take no more of Percodan than your doctor directs.

  • If you miss a dose...Take it as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Never take 2 doses at the same time.
  • Storage instructions...Store at room temperature. Protect from light.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Percodan. Many of the side effects associated with Percodan go away if you lie down.

  • Side effects may include:Constipation, dizziness, exaggerated feelings of well-being or sadness, itching, light-headedness, nausea, sedation, vomiting

Why should Percodan not be prescribed?

If you are allergic to either aspirin or oxycodone, you will not be able to use this product.

Special warnings about Percodan

Percodan can impair the skills needed to drive a car or operate machinery safely. Do not attempt to drive if you are not fully alert.

In children and teenagers who have a viral infection, the aspirin in Percodan can trigger a severe and even fatal disorder called Reye's syndrome. Do not give Percodan to any child with an illness such as flu or chickenpox.

Percodan's effects may be severely exaggerated in people who have suffered a head injury. The drug should also be used with caution if you have a history of peptic ulcer disease or a clotting disorder.

Make sure your doctor knows if you have any of the following medical conditions: abdominal disorders, a thyroid condition, Addison's disease, kidney problems, liver problems, an enlarged prostate, or difficulty urinating. Percodan should be used with extra caution under these circumstances.

Possible food and drug interactions when taking Percodan

If Percodan is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Percodan with the following:

AlcoholAntidepressantsBlood-thinning drugsGout medicationsMajor tranquilizersOther narcotic pain killersPromethazineSleep aidsTranquilizers

Special information if you are pregnant or breastfeeding

It is not known whether Percodan can harm a developing baby. The drug is not recommended for pregnant women under ordinary circumstances, and you should inform your doctor immediately if you become pregnant. Also consult your doctor before using Percodan while breastfeeding.

Recommended dosage for Percodan


The usual dose is one tablet every 6 hours as needed for pain. Your doctor may adjust the dosage according to the severity of pain and your response to the drug. The maximum dose is 12 tablets per day.


A special formulation of Percodan called "Percodan Demi" is available for children. Do not give full-strength Percodan to a child.


An overdose of Percodan can be fatal. If you suspect an overdose, seek medical attention immediately.

  • Signs of Percodan overdose may include:Bluish skin, cold and clammy skin, decreased breathing, limp muscles, sleepiness progressing to stupor or coma, slow heartbeat

Untreated, a severe overdose can shut down breathing and stop the heart.

  • Percodan Prescribing Information (FDA)
  • Percodan MedFacts Consumer Leaflet (Wolters Kluwer)
  • Percodan Consumer Overview
  • Endodan Prescribing Information (FDA)

See Also...

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