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Drugs reference index «Ansaid»

Ansaid
Ansaid


Ansaid

Generic Name: flurbiprofen (Oral route)

flur-bi-PROE-fen

Oral routeTablet
  • CARDIOVASCULAR RISK
    • NSAIDs may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. This risk may increase with duration of use. Patients with cardiovascular disease or risk factors for cardiovascular disease may be at greater risk
  • Flurbiprofen is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery .
  • GASTROINTESTINAL RISK
    • NSAIDs cause an increased risk of serious gastrointestinal adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients are at greater risk for serious gastrointestinal events .

NSAIDs may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. This risk may be increased in patients with cardiovascular disease or risk factors for cardiovascular disease. Flurbiprofen is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery. NSAIDs can also cause an increased risk of serious gastrointestinal adverse events especially in the elderly, including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal .

Commonly used brand name(s):

In the U.S.

  • Ansaid

Available Dosage Forms:

  • Tablet
  • Capsule, Extended Release

Therapeutic Class: Analgesic

Pharmacologic Class: NSAID

Chemical Class: Propionic Acid (class)

Uses For Ansaid

Flurbiprofen is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve symptoms of arthritis (osteoarthritis and rheumatoid arthritis), such as inflammation, swelling, stiffness, and joint pain. However, this medicine does not cure arthritis and will help you only as long as you continue to take it .

Flurbiprofen may also be used for other problems as determined by your doctor .

This medicine is available only with your doctor's prescription .

Before Using Ansaid

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of flurbiprofen in the pediatric population. Safety and efficacy have not been established .

Geriatric

Appropriate studies performed to date have not demonstrated geriatrics-specific problems that would limit the usefulness of flurbiprofen in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require adjustment of dosage in patients receiving flurbiprofen .

Pregnancy

Pregnancy CategoryExplanation
All TrimestersBAnimal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Ketorolac

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Ardeparin
  • Beta Glucan
  • Certoparin
  • Dalteparin
  • Danaparoid
  • Enoxaparin
  • Ginkgo
  • Methotrexate
  • Nadroparin
  • Parnaparin
  • Pemetrexed
  • Reviparin
  • Tacrolimus
  • Tinzaparin

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acenocoumarol
  • Acetohexamide
  • Alacepril
  • Amiloride
  • Azosemide
  • Bemetizide
  • Benazepril
  • Bendroflumethiazide
  • Benzthiazide
  • Bumetanide
  • Buthiazide
  • Candesartan Cilexetil
  • Canrenoate
  • Captopril
  • Chlorothiazide
  • Chlorpropamide
  • Chlorthalidone
  • Cilazapril
  • Citalopram
  • Clopamide
  • Clopidogrel
  • Clovoxamine
  • Cyclopenthiazide
  • Cyclosporine
  • Cyclothiazide
  • Delapril
  • Desvenlafaxine
  • Dicumarol
  • Duloxetine
  • Enalaprilat
  • Enalapril Maleate
  • Eprosartan
  • Escitalopram
  • Ethacrynic Acid
  • Femoxetine
  • Flesinoxan
  • Fluoxetine
  • Fluvoxamine
  • Fosinopril
  • Furosemide
  • Gliclazide
  • Glimepiride
  • Glipizide
  • Gliquidone
  • Glyburide
  • Hydrochlorothiazide
  • Hydroflumethiazide
  • Imidapril
  • Indapamide
  • Irbesartan
  • Lisinopril
  • Losartan
  • Methyclothiazide
  • Metolazone
  • Milnacipran
  • Moexipril
  • Nefazodone
  • Olmesartan Medoxomil
  • Paroxetine
  • Pentopril
  • Perindopril
  • Phenprocoumon
  • Piretanide
  • Polythiazide
  • Quinapril
  • Quinethazone
  • Ramipril
  • Sertraline
  • Spirapril
  • Spironolactone
  • Tasosartan
  • Telmisartan
  • Temocapril
  • Tolazamide
  • Tolbutamide
  • Torsemide
  • Trandolapril
  • Triamterene
  • Trichlormethiazide
  • Valsartan
  • Venlafaxine
  • Xipamide
  • Zimeldine
  • Zofenopril

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Anemia or
  • Asthma or
  • Bleeding problems or
  • Blood clots or
  • Edema (fluid retention or body swelling) or
  • Heart attack, history of or
  • Heart disease (e.g., congestive heart failure) or
  • High blood pressure or
  • Kidney disease or
  • Liver disease (e.g., hepatitis) or
  • Stomach or intestinal ulcers or bleeding or
  • Stroke, history of—Use with caution. This medicine may make these conditions worse .
  • Aspirin sensitivity, history of—This medicine should NOT be used in patients with this condition .
  • Heart surgery (e.g., coronary artery bypass graft [CABG] surgery)—This medicine should NOT be used to relieve pain right before or after the surgery .

Proper Use of Ansaid

For safe and effective use of this medicine, do not take more of it, do not take it more often, and do not take it for a longer time than ordered by your doctor. Taking too much of this medicine may increase the chance of unwanted effects, especially in elderly patients .

When used for severe or continuing arthritis, this medicine must be taken regularly as ordered by your doctor in order for it to help you. This medicine usually begins to work within one week, but in severe cases up to two weeks or even longer may pass before you begin to feel better. Also, several weeks may pass before you feel the full effects of this medicine.

To lessen stomach upset, you may take this medicine with food.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (tablets):
    • For osteoarthritis and rheumatoid arthritis:
      • Adults—At first, 200 to 300 milligrams (mg) per day, divided into two to four equal doses. Your doctor may increase or decrease your dose as needed. However, each dose usually is not more than 100 mg.
      • Children—Use and dose must be determined by your doctor .

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using Ansaid

It is very important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it. Blood and urine tests may be needed to check for unwanted effects .

This medicine may raise your risk of having a heart attack or stroke. This is more likely in people who already have heart disease. People who use this medicine for a long time might also have a higher risk .

This medicine may cause bleeding in your stomach or intestines. These problems can happen without warning signs. This is more likely if you have had a stomach ulcer in the past, if you smoke or drink alcohol regularly, if you are over 60 years old, if you are in poor health, or if you are using certain other medicines (a steroid or a blood thinner) .

Serious skin reactions can occur during treatment with this medicine. Check with your doctor right away if you have any of the following symptoms while taking this medicine: blistering, peeling, loosening of skin, chills, cough, diarrhea, fever, itching, joint or muscle pain, red skin lesions, sore throat, sores, ulcers, white spots in mouth or on lips, or unusual tiredness or weakness .

Possible warning signs of some serious side effects that can occur during treatment with this medicine may include swelling of the face, fingers, feet, and/or lower legs; severe stomach pain, black, tarry stools, and/or vomiting of blood or material that looks like coffee grounds; unusual weight gain; yellow skin or eyes; decreased urination; unusual bleeding or bruising; and/or skin rash. Also, signs of serious heart problems could occur such as chest pain, tightness in chest, fast or irregular heartbeat, unusual flushing or warmth of skin, weakness, or slurring of speech. Stop taking this medicine and check with your doctor immediately if you notice any of these warning signs .

This medicine may also cause a serious type of allergic reaction called anaphylaxis. Although this is rare, it may occur often in patients who are allergic to aspirin or other nonsteroidal anti-inflammatory drugs. Anaphylaxis requires immediate medical attention. The most serious signs of this reaction are very fast or irregular breathing, gasping for breath, wheezing, or fainting. Other signs may include changes in skin color of the face; very fast but irregular heartbeat or pulse; hive-like swellings on the skin; and puffiness or swelling of the eyelids or around the eyes. If these effects occur, get emergency help at once .

Using this medicine while you are pregnant can harm your unborn baby. If you think you have become pregnant while using this medicine, tell your doctor right away .

Check with your doctor immediately if blurred vision, difficulty in reading, or any other change in vision occurs during or after your treatment. Your doctor may want you to have your eyes checked by an ophthalmologist (eye doctor) .

Ansaid Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common
  • Abdominal pain
  • bladder pain
  • bloody or black, tarry stools
  • bloody or cloudy urine
  • constipation
  • difficult, burning, or painful urination
  • frequent urge to urinate
  • lower back or side pain
  • rash
  • severe stomach pain
  • swelling
  • vomiting of blood or material that looks like coffee grounds
Rare
  • Back or leg pains
  • bleeding gums
  • blistering, peeling, loosening of skin
  • blood in vomit
  • bloody diarrhea
  • bloody nose
  • blurred vision
  • burning feeling in chest or stomach
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chest pain
  • chills
  • clay-colored stools
  • cough
  • cracks in the skin
  • dark urine
  • decreased urine output
  • difficulty breathing
  • difficulty swallowing
  • dilated neck veins
  • dizziness
  • extreme fatigue
  • fast heartbeat
  • feeling faint, dizzy, or lightheaded
  • feeling of warmth or heat
  • fever with or without chills
  • flushing or redness of skin, especially on face and neck
  • general feeling of tiredness or weakness
  • greatly decreased frequency of urination
  • headache
  • high fever
  • hives
  • hoarseness
  • increased blood pressure
  • increased sensitivity of skin to sunlight
  • increased thirst
  • indigestion
  • irregular breathing
  • irregular heartbeat
  • itching
  • joint pain, stiffness, or swelling
  • large, flat, blue or purplish patches in the skin
  • large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • light-colored stools
  • loss of appetite
  • loss of heat from the body
  • muscle pain
  • nausea
  • nervousness
  • noisy breathing
  • nosebleeds
  • pale skin
  • pinpoint red or purple spots on skin
  • pounding in the ears
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • red irritated eyes
  • red skin lesions, often with a purple center
  • red, swollen skin
  • redness or other discoloration of skin
  • redness, swelling, or soreness of tongue
  • scaly skin
  • severe or continuing stomach pain
  • severe sunburn
  • shakiness and unsteady walk
  • shortness of breath
  • skin rash, encrusted, scaly and oozing
  • slow or fast heartbeat
  • sore throat
  • sores, ulcers, or white spots on lips or in mouth
  • stomach bloating or cramping
  • stomach upset
  • sweating
  • swelling of face, fingers, feet, or lower legs
  • swelling or inflammation of the mouth
  • swollen or painful glands
  • tenderness in stomach area
  • tightness in chest
  • troubled breathing
  • unpleasant breath odor
  • unsteadiness, trembling, or other problems with muscle control or coordination
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • upper right abdominal pain
  • vomiting
  • vomiting of blood
  • weight gain
  • weight loss
  • wheezing
  • yellow eyes or skin
Symptom of overdose
  • Change in consciousness
  • fast or slow, or shallow breathing
  • heartburn
  • loss of consciousness
  • pain or discomfort in chest, upper stomach, or throat
  • pale or blue lips, fingernails, or skin
  • unusual drowsiness, dullness, or feeling of sluggishness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Acid or sour stomach
  • belching
  • changes in vision
  • continuing ringing or buzzing or other unexplained noise in ear
  • diarrhea
  • discouragement
  • excess air or gas in stomach or intestines
  • fear
  • feeling of constant movement of self or surroundings
  • feeling sad or empty
  • full feeling
  • general feeling of discomfort or illness
  • hearing loss
  • irritability
  • lack of appetite
  • lack or loss of strength
  • lightheadedness
  • loss of interest or pleasure
  • loss of memory
  • passing gas
  • problems with memory
  • runny nose
  • sensation of spinning
  • sleepiness
  • sleeplessness
  • sneezing
  • stomach discomfort
  • stuffy nose
  • tremor
  • trouble concentrating
  • trouble sleeping
  • unable to sleep
Rare
  • Burning, dry, or itching eyes
  • confusion
  • discharge, excessive tearing
  • redness, pain, swelling of eye, eyelid, or inner lining of eyelid
  • transient, mild, pleasant aromatic odor
  • twitching

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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  • Ansaid Prescribing Information (FDA)
  • Ansaid MedFacts Consumer Leaflet (Wolters Kluwer)
  • Ansaid Detailed Consumer Information (PDR)
  • Ansaid Concise Consumer Information (Cerner Multum)
  • Flurbiprofen Professional Patient Advice (Wolters Kluwer)

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