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Drugs reference index «Antipyrine/Benzocaine»


Antipyrine / Benzocaine

Pronunciation: (an-tee-PYE-reen/BEN-zoe-kane)Class: Otic preparation

Trade Names:Benzocaine Otic- Solution antipyrine 5.4% and benzocaine 1.4% with dehydrated glycerin

Trade Names:Neotic- Solution antipyrine 5.4%, benzocaine 1%, glycerin 2%, and zinc 1%

Auralgan (Canada)


Decongestant/analgesic/skin protectant

Indications and Usage

Treatment of acute otitis media of various etiologies; removal of cerumen.


Perforated tympanic membrane or discharge; hypersensitivity to any of the components or related substances.

Dosage and Administration

Acute Otitis MediaAdults and Children

Otic Instill solution to run along the wall of the ear canal until filled, then insert cotton pledget moistened with the otic solution into meatus. Repeat every 1 to 2 h until pain and congestion is relieved.

Removal of CerumenAdults and Children

Otic Instill solution 3 times/day for 2 or 3 days. Following instillation, a cotton pledget moistened with the product should be inserted into the meatus.

General Advice

  • Avoid contaminating the dropper with material from the ear, fingers, and other sources.
  • Warm the bottle to body temperature.


Store at 59° to 86°F. Protect from light and heat.

Drug Interactions

None well documented.

Laboratory Test Interactions

None well documented.



Category C .



Patient Information

  • Remind patient, family, or caregiver that medication is for use in the ear only.
  • Teach patient proper technique for instilling ear drops: wash hands; do not allow dropper to touch ear. Tilt head to side or lie on side; instill prescribed number of drops; moisten cotton pledget and insert into ear canal; replace dropper.
  • Advise patient, family, or caregiver to only use supplied dropper and to not rinse dropper after use.
  • Advise patient, family, or caregiver to notify health care provider if symptoms do not improve or if irritation, inflammation, or itching of ear canal is noted.

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