Class Name: antithyroid agent (Oral route, Rectal route)
Commonly used brand name(s):
In the U.S.
Available Dosage Forms:
Methimazole and propylthiouracil are used to treat conditions in which the thyroid gland produces too much thyroid hormone.
These medicines work by making it harder for the body to use iodine to make thyroid hormone. They do not block the effects of thyroid hormone that was made by the body before their use was begun.
These medicines are available only with your doctor's prescription.
Tell your doctor if you have ever had any unusual or allergic reaction to medicines in this group or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
This medicine has been used in children and teenagers and, in effective doses, has not been shown to cause different side effects or problems in children than it does in adults.
Elderly people may have an increased chance of certain side effects during treatment. Your doctor may need to take special precautions while you are taking this medicine.
Use of too large a dose during pregnancy may cause problems in the fetus. However, use of the proper dose, with careful monitoring by the doctor, is not likely to cause problems.
These medicines pass into breast milk. (Methimazole passes into breast milk more freely and in higher amounts than propylthiouracil.) However, your doctor may allow you to continue to breast-feed, if your dose is low and the infant gets frequent check-ups. If you are taking a large dose, it may be necessary for you to stop breast-feeding during treatment.
Using medicines in this class with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
The presence of other medical problems may affect the use of medicines in this class. Make sure you tell your doctor if you have any other medical problems, especially:
Use this medicine only as directed by your doctor. Do not use more or less of it and do not use it more often or for a longer time than your doctor ordered. To do so may increase the chance of side effects.
This medicine works best when there is a constant amount in the blood. To help keep the amount constant, do not miss any doses. Also, if you are taking more than one dose a day, it is best to take the doses at evenly spaced times day and night. For example, if you are to take 3 doses a day, the doses should be spaced about 8 hours apart. If this interferes with your sleep or other daily activities, or if you need help in planning the best times to take your medicine, check with your health care professional.
Food in your stomach may change the amount of methimazole that is able to enter the bloodstream. To make sure that you always get the same effects, try to take methimazole at the same time in relation to meals every day. That is, always take it with meals or always take it on an empty stomach.
The dose medicines in this class will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of these medicines. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
If you miss more than one dose or if you have any questions about this, check with your doctor.
Keep out of the reach of children.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Do not keep outdated medicine or medicine no longer needed.
It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly and to check for unwanted effects.
It may take several days or weeks for this medicine to work. However, do not stop taking this medicine without first checking with your doctor. Some medical problems may require several years of continuous treatment.
Before having any kind of surgery (including dental surgery) or emergency treatment, tell the medical doctor or dentist in charge that you are taking this medicine.
Check with your doctor right away if you get an injury, infection, or illness of any kind. Your doctor may want you to stop taking this medicine or change the amount you are taking.
While you are being treated with antithyroid agents, and after you stop treatment with it, do not have any immunizations (vaccinations) without your doctor's approval. Antithyroid agents may lower your body's resistance and there is a chance you might get the infection the immunization is meant to prevent. In addition, other persons living in your household should not take or have recently taken oral polio vaccine since there is a chance they could pass the polio virus on to you. Also, avoid other persons who have taken oral polio vaccine. Do not get close to them, and do not stay in the same room with them for very long. If you cannot take these precautions, you should consider wearing a protective face mask that covers the nose and mouth.
Before you have any medical tests, tell the doctor in charge that you are taking this medicine. The results of some tests may be affected by this medicine.
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:Less common
Check with your doctor as soon as possible if any of the following side effects occur:More common
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:Less common
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
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