Generic Name: dolasetron (doe LAS e tron)Brand Names: Anzemet
Dolasetron blocks the actions of chemicals in the body that can trigger nausea and vomiting.
Dolasetron is used to prevent nausea and vomiting that may be caused by surgery or by medicine to treat cancer (chemotherapy).
Dolasetron may be used for other purposes not listed in this medication guide.
Before taking dolasetron, tell your doctor if you have a heart rhythm disorder; a personal or family history of Long QT syndrome, or an electrolyte imbalance (such as low levels of potassium or magnesium in your blood).
Dolasetron is usually taken 1 hour before chemotherapy or 2 hours before surgery. Tell your doctor if you forget to take the medication within the specified amount of time before your procedure.
If you have any of these other conditions, you may need a dose adjustment or special tests to safely take dolasetron:
a heart rhythm disorder;
a personal or family history of Long QT syndrome; or
an electrolyte imbalance (such as low levels of potassium or magnesium in your blood).
Dolasetron orally disintegrating tablets may contain phenylalanine. Tell your doctor if you have phenylketonuria (PKU).
Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.
Dolasetron is usually taken 1 hour before chemotherapy or 2 hours before surgery. Follow your doctor's instructions.Store dolasetron at room temperature away from moisture and heat.
See also: Anzemet dosage in more detail
Tell your doctor if you forget to take your dose within 1 hour before chemotherapy or 2 hours before surgery. Do not take extra medicine to make up the missed dose.
Overdose symptoms may include feeling light-headed, or fainting.
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
fast or pounding heartbeats;
feeling like you might pass out;
slow heart rate, weak pulse, fainting, slow breathing; or
chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling.
Less serious side effects may include:
diarrhea or constipation;
fever, sweating; or
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Tell your doctor if you use other medications that can affect heart rate, especially:
arsenic trioxide (Trisenox);
a diuretic (water pill);
an antibiotic such as clarithromycin (Biaxin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin), levofloxacin (Levaquin), moxifloxacin (Avelox), or pentamidine (NebuPent, Pentam);
an antidepressant such as amitriptylline (Elavil, Vanatrip), clomipramine (Anafranil), or desipramine (Norpramin);
anti-malaria medications such as chloroquine (Arelan), or mefloquine (Lariam);
heart rhythm medicine such as amiodarone (Cordarone, Pacerone), dofetilide (Tikosyn), disopyramide (Norpace), ibutilide (Corvert), procainamide (Pronestyl), propafenone (Rythmol), quinidine (Quin-G), or sotalol (Betapace);
other medicine to prevent or treat nausea and vomiting, such as ondansetron (Zofran), granisetron (Kytril), or palonosetron (Aloxi);
medicines to treat psychiatric disorders, such as chlorpromazine (Thorazine), clozapine (FazaClo, Clozaril), haloperidol (Haldol), pimozide (Orap), thioridazine (Mellaril), or ziprasidone (Geodon);
migraine headache medicine such as sumatriptan (Imitrex) or zolmitriptan (Zomig); or
narcotic medication such as levomethadyl (Orlaam), or methadone (Dolophine, Methadose).
This list is not complete and there may be other drugs that can interact with dolasetron. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.