Generic name: Dolasetron mesylateBrand names: Anzemet
Anzemet is used to prevent the nausea and vomiting that often accompany cancer chemotherapy and usually trouble patients who've received anesthesia during surgery. The drug works by blocking the action of one of the brain's chemical messengers, serotonin, on the nerves that trigger vomiting.
Anzemet needs time to begin working. If you are using it to prevent nausea and vomiting due to chemotherapy, you must remember to take it within an hour before each treatment.
Do not take more than prescribed.
--If you miss a dose...
And you remember during or after your chemotherapy treatment, ask your doctor how to proceed. Before future treatments, try to remember to take the drug an hour in advance. Do not take 2 doses at once.
Store at room temperature away from light.
Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Anzemet.
If Anzemet gives you an allergic reaction, you cannot use Anzemet.
Anzemet can affect the heartbeat and could worsen a heart condition. If you suffer from irregular heartbeat or other cardiac problems, be sure the doctor is aware of this.
If Anzemet is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Anzemet with the following:Atenolol (Tenormin)Chemotherapy drugs such as Adriamycin, DaunoXome, and IdamycinCimetidine (Tagamet)Diuretic drugs (water pills) such as furosemide (Lasix) and hydrochlorothiazide (HydroDIURIL)Drugs that steady the heartbeat, such as Cordarone, Mexitil, Norpace CR, Procan SR, Quinidex, Quinaglute, and Rythmol
There are no adequate studies of Anzemet's effects during pregnancy. It should therefore be used only if clearly needed. Researchers also have not determined whether Anzemet appears in breast milk. Caution is advised if you are breastfeeding.
Prevention of Cancer Chemotherapy-Induced Nausea and Vomiting
The recommended oral dosage is 100 milligrams taken within 1 hour before chemotherapy.
The recommended oral dosage in patients 2 to 16 years old is 1.8 milligrams per 2.2 pounds of body weight taken within one hour before chemotherapy, up to a maximum dose of 100 milligrams. The safety and effectiveness of Anzemet in children under 2 years old have not been established.
Prevention of Postoperative Nausea and Vomiting
The recommended oral dosage is 100 milligrams taken within 2 hours before surgery.
The recommended oral dosage in patients 2 to 16 years old is 1.2 milligrams per 2.2 pounds of body weight taken within 2 hours before surgery, up to a maximum dose of 100 milligrams. The safety and effectiveness of Anzemet in children under 2 years old have not been established.
Information on massive overdosage with Anzemet is limited. However, any medication taken in excess can have serious consequences. If you suspect an overdose, seek emergency medical treatment immediately.